Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Susan M. Ludeman"'
Publikováno v:
Drug Metabolism and Disposition. 43:1084-1090
The hydroxylation and N-dechloroethylation of deuterated ifosfamide (d4IFO) and ifosfamide (IFO) by several human P450s have been determined and compared. d4IFO was synthesized with deuterium at the alpha and alpha′ carbons to decrease the rate of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e7290c1201a9f25fcfca2078482222
https://doi.org/10.1124/dmd.115.063628
https://doi.org/10.1124/dmd.115.063628
Autor:
Amy L. Stark, Wendy B. London, Navin Pinto, Sharon J. Diskin, Nancy J. Cox, M E Dolan, Susan L. Cohn, Hae Kyung Im, Nirav N. Antao, Eric R. Gamazon, Jamie Myers, Anuar Konkashbaev, John M. Maris, Susan M. Ludeman
Publikováno v:
Clinical pharmacology and therapeutics
High-risk neuroblastoma is an aggressive malignancy, with high rates of treatment failure. We evaluated genetic variants associated with in vitro sensitivity to two derivatives of cyclophosphamide for association with clinical response in a separate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::678982b07d2f849ae1809e26f0b8689d
http://europepmc.org/articles/PMC4029857
http://europepmc.org/articles/PMC4029857
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 57:110-114
The prodrugs cyclophosphamide (CP) and ifosfamide (IF) each metabolize to an active alkylating agent through a cytochrome P450-mediated oxidation at the C-4 position. Competing with this activation pathway are enzymatic oxidations at the exocyclic α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6123767b88270a99d9438e99a74af73e
https://doi.org/10.1002/jlcr.3142
https://doi.org/10.1002/jlcr.3142
Autor:
Susan M. Ludeman, Jacob Farhi, Gania Kessler-Icekson, Ronit Abir, Abraham Tsur, Roni Prag-Rosenberg, Muayad A. Zahalka, Avi Ben-Haroush, Yechezkel Lande, Benjamin Fisch
Publikováno v:
Reproductive biomedicine online. 34(1)
How chemotherapy affects dormant ovarian primordial follicles is unclear. The 'burnout' theory, studied only in mice, suggests cyclophosphamide enhances primordial follicle activation. Using 4-hydroperoxycyclophosphamide (4hc) and phosphoramide musta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf7bb97f19ffd80639e6a5e675672413
https://pubmed.ncbi.nlm.nih.gov/27815062
https://pubmed.ncbi.nlm.nih.gov/27815062
Autor:
Michael P. Gamcsik, Rebecca L. Mutesi, Michael A. D'Alessandro, James B. Springer, Prince N. A. Amoyaw, Collin R. Dempsey, Susan M. Ludeman
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 54:607-612
Effects of neurodegeneration have been linked to inefficient detoxification of free radicals due to lowered concentrations of antioxidants, especially glutathione, in the brain. In the biosynthesis of glutathione, cysteine concentration is generally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42adbdc33a51bc82b545db05dfa3833d
https://doi.org/10.1002/jlcr.1904
https://doi.org/10.1002/jlcr.1904
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 50:115-122
A variety of deuterated 3-amino-1-propanols were made by the LiAlD 4 or AlD 3 reduction of nitrile or ester precursors. The labeled aminopropanols and/or deuterated bis(2-chloroethyl)amines were used to synthesize [4,4- 2 H 2 ]-, [6,6- 2 H 2 ]-, [α,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::570156c4e3b43b926dd3d79bf6bb32b3
https://doi.org/10.1002/jlcr.1182
https://doi.org/10.1002/jlcr.1182
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 50:79-84
Reduction of diethyliminodiacetate with [ 3 H]-LiAlH 4 and then reaction with SOCl 2 gave bis(2-chloro-2-[ 3 H] ethyl)amine hydrochloride. This compound, together with [ 33 P]-phosphorus oxychloride, provided for the synthesis of [ 3 H, 33 P]-phospho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e3a5c245fec4f8af8fdc272218c16b6
https://doi.org/10.1002/jlcr.1157
https://doi.org/10.1002/jlcr.1157
Autor:
Susan M. Ludeman, Mihir C. Gandhi, M. Eileen Dolan, Sonali M. Smith, Lynette R. Wilson, James B. Springer
Publikováno v:
Cancer Chemotherapy and Pharmacology. 52:291-302
O6-benzylguanine (BG) is a unique purine analog that has been shown to influence nitrogen mustard activity and increase cytotoxicity. Ifosfamide is a nitrogen mustard with growing clinical applications; effective modulation may lead to improved effic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1020ac196df964a6ebc29fc1f3ea00df
https://doi.org/10.1007/s00280-003-0672-2
https://doi.org/10.1007/s00280-003-0672-2
Autor:
Drazen Raucher, Narayanan Balu, Susan M. Ludeman, Matthew R. Dreher, Ashutosh Chilkoti, O. Michael Colvin
Publikováno v:
Journal of Controlled Release. 91:31-43
Thermally responsive elastin-like polypeptides (ELPs) were synthesized by recombinant DNA techniques and conjugated to doxorubicin through an acid-labile hydrazone bond to enable release of the drug in the acidic environment of lysosomes. The thermal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8258f46384e87fabb11d989d991d5ca
https://doi.org/10.1016/s0168-3659(03)00216-5
https://doi.org/10.1016/s0168-3659(03)00216-5
Autor:
Michael P. Gamcsik, Kai-Liu Shao, Susan M. Ludeman, O. Michael Colvin, David J. Adams, James B. Springer, Jila H. Boal, James L. Flowers
Publikováno v:
Cancer Chemotherapy and Pharmacology. 45:335-344
A number of investigators have observed that the use of 4-hydroperoxycyclophosphamide (4-HC) in multiwell plate cytotoxicity assays can be associated with toxicity to cells in wells that contain no drug. Previous reports have implicated diffusion of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed720d964d5f54b97ef7f46e2338a94e
https://doi.org/10.1007/s002800050049
https://doi.org/10.1007/s002800050049