Zobrazeno 1 - 10
of 286
pro vyhledávání: '"Susan M. Lea"'
Autor:
Stephen R. Garrett, Nicole Mietrach, Justin Deme, Alina Bitzer, Yaping Yang, Fatima R. Ulhuq, Dorothee Kretschmer, Simon Heilbronner, Terry K. Smith, Susan M. Lea, Tracy Palmer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The type VII protein secretion system (T7SS) is found in many Gram-positive bacteria and in pathogenic mycobacteria. All T7SS substrate proteins described to date share a common helical domain architecture at the N-terminus that typically in
Externí odkaz:
https://doaj.org/article/614445c295ff47b0b6acfe1519669f17
Autor:
Yevgen Levdansky, Tobias Raisch, Justin C. Deme, Filip Pekovic, Hans Elmlund, Susan M. Lea, Eugene Valkov
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-8 (2023)
Abstract NOT1, NOT10, and NOT11 form a conserved module in the CCR4-NOT complex, critical for post-transcriptional regulation in eukaryotes, but how this module contributes to the functions of the CCR4-NOT remains poorly understood. Here, we present
Externí odkaz:
https://doaj.org/article/5824b314baae41ec8c157763276b6d09
Autor:
Katharina Braunger, Jiyoon Ahn, Matthijs M. Jore, Steven Johnson, Terence T. L. Tang, Dennis V. Pedersen, Gregers R. Andersen, Susan M. Lea
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Properdin is the only known positive regulator of the human complement system, stabilising the convertase C3 in the alternative pathway of complement activation. Here, the authors report the identification and characterisation of a species-specific p
Externí odkaz:
https://doaj.org/article/5b1add1310284327ac11638749c24bcd
Autor:
Rachel J. Harding, Justin C. Deme, Johannes F. Hevler, Sem Tamara, Alexander Lemak, Jeffrey P. Cantle, Magdalena M. Szewczyk, Nola Begeja, Siobhan Goss, Xiaobing Zuo, Peter Loppnau, Alma Seitova, Ashley Hutchinson, Lixin Fan, Ray Truant, Matthieu Schapira, Jeffrey B. Carroll, Albert J. R. Heck, Susan M. Lea, Cheryl H. Arrowsmith
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Harding et al. present a biophysical and structural characterization of the complex between huntingtin (HTT) and HAP40 proteins. They show that the abundance of HAP40 is coupled with that of HTT and that there is greater conformational variety in the
Externí odkaz:
https://doaj.org/article/eb1fd59dd9ce42829c1dde1a83e58ffc
Autor:
Joanne L. Parker, Justin C. Deme, Dimitrios Kolokouris, Gabriel Kuteyi, Philip C. Biggin, Susan M. Lea, Simon Newstead
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
System xc- is a cystine transporter that is expressed in the plasma membrane and imports cystine in exchange for intracellular glutamate. Here, the authors present the cryo-EM structure of human system xc- both in the apo form and the glutamate bound
Externí odkaz:
https://doaj.org/article/014ea01a12f34079b4b5dbfabd780812
Autor:
Yoel A. Klug, Justin C. Deme, Robin A. Corey, Mike F. Renne, Phillip J. Stansfeld, Susan M. Lea, Pedro Carvalho
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Lipid droplet biogenesis is orchestrated by the conserved membrane protein Seipin via an unknown mechanism. Here, the authors use structural, biochemical and molecular dynamics simulation approaches to reveal the mechanism of lipid droplet formation
Externí odkaz:
https://doaj.org/article/3c961ba27c154e8598353be409285d56
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT Gliding motility using cell surface adhesins, and export of proteins by the type IX secretion system (T9SS) are two phylum-specific features of the Bacteroidetes. Both of these processes are energized by the GldLM motor complex, which transd
Externí odkaz:
https://doaj.org/article/657e1ee0f497470dbe4a4342c6dda2af
Autor:
Lucas Kuhlen, Steven Johnson, Andreas Zeitler, Sandra Bäurle, Justin C. Deme, Joseph J. E. Caesar, Rebecca Debo, Joseph Fisher, Samuel Wagner, Susan M. Lea
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Export of proteins by type three secretion systems occurs through an export gate that is localized in the periplasm. Here, the authors present the cryo-EM structure of the Vibrio mimicus export gate complex with FlhB, which plays a major role in swit
Externí odkaz:
https://doaj.org/article/6cc514e45205439e8975bcd521c5273c
Autor:
Arun Dhillon, Justin C. Deme, Emily Furlong, Dorina Roem, Ilse Jongerius, Steven Johnson, Susan M. Lea
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
ABSTRACT Complement, contact activation, coagulation, and fibrinolysis are serum protein cascades that need strict regulation to maintain human health. Serum glycoprotein, a C1 inhibitor (C1-INH), is a key regulator (inhibitor) of serine proteases of
Externí odkaz:
https://doaj.org/article/089a29c6c6894167ac20a9fe9aa84830
Autor:
Joseph Caesar, Cyril F. Reboul, Chiara Machello, Simon Kiesewetter, Molly L. Tang, Justin C. Deme, Steven Johnson, Dominika Elmlund, Susan M. Lea, Hans Elmlund
Publikováno v:
Journal of Structural Biology: X, Vol 4, Iss , Pp 100040- (2020)
We here introduce the third major release of the SIMPLE (Single-particle IMage Processing Linux Engine) open-source software package for analysis of cryogenic transmission electron microscopy (cryo-EM) movies of single-particles (Single-Particle Anal
Externí odkaz:
https://doaj.org/article/f09952d6ef1d4c0cb0bc4501bc6bc878