Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Susan M. Keating"'
Autor:
Robert T. McCormack, Daniel Stetson, Dana E. Connors, J. Carl Barrett, Kenneth D. Cole, Steven P. Lund, Chris Karlovich, Thomas Forbes, P. Mickey Williams, Megan H. Cleveland, Laura M. Yee, Christie J. Lau, Cloud P. Paweletz, Gary J. Kelloff, Benoit Destenaves, Hua-Jun He, Susan M. Keating
Publikováno v:
JCO Precision Oncology
PURPOSEWe report the results from a Foundation for the National Institutes of Health Biomarkers Consortium project to address the absence of well-validated quality control materials (QCMs) for circulating tumor DNA (ctDNA) testing. This absence is co
Autor:
Gary J. Kelloff, Jennifer Boyle, Klaus Pantel, Dana E. Connors, Mark Stewart, Thomas Schlange, J.D. Alvarez, Susan M. Keating, Christian D. Rolfo, Lauren Leiman, Carolyn Hiller, Caroline C. Sigman, Massimo Cristofanilli, Jeff Allen, Emily Morgan, Diana M. Merino, Robert T. McCormack, María José Serrano, A. Pia Sanzone
Publikováno v:
Critical reviews in oncology/hematology. 156
The promise of precision medicine as a model to customize health care to the individual patient is heavily dependent upon new genetic tools to classify and characterize diseases and their hosts. Liquid biopsies serve as a safe alternative to solid bi
Autor:
David D. Chang, D. Lansing Taylor, Keisuke Kuida, E. David Litwack, Gary J. Kelloff, Caroline C. Sigman, Gregory Friberg, Jerry S.H. Lee, Emily J. Greenspan, Christopher M. Hartshorn, Susan M. Keating, Peter Kuhn, Anne L. Plant
Publikováno v:
Clinical and Translational Science. 11:267-276
The high-content interrogation of single cells with platforms optimized for the multiparameter characterization of cells in liquid and solid biopsy samples can enable characterization of heterogeneous populations of cells ex vivo. Doing so will advan
Autor:
Caroline C. Sigman, Anand Kolatkar, Kisha Thomas, Gregory T. Baxter, Susan M. Keating, Peter Kuhn
Publikováno v:
Clinical Pharmacology & Therapeutics. 102:777-785
Planning and transfer of a new technology platform developed in an academic setting to a start-up company for medical diagnostic product development may appear daunting and costly in terms of complexity, time, and resources. In this review we outline
Autor:
Susan M Keating, Michael D Humphrey
Publikováno v:
The Australian and New Zealand Journal of Obstetrics and Gynaecology. 44:10-13
Objective: To examine reasons for women not accessing antenatal care, and subsequent pregnancy outcomes for this group of women. Design: Retrospective observational study between 1992 and 2001. Setting: Large public provincial referral obstetric unit
Autor:
Susan M. Keating, James C. Marsters, Daniel P. Sutherlin, Sherman Fong, Lisa D. Caris, Kevin R Clark, Georgette Castanedo, John B. Nicholas, Henry Chiu, Fredrick C. Sailes, Maureen Beresini, David Y. Jackson, N. Dubree
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:2913-2917
Two structural classes of dual α4β1/α4β7 integrin antagonists were investigated via solid-phase parallel synthesis. Using an acylated amino acid backbone, lead compounds containing biphenylalanine or tyrosine carbamate scaffolds were optimized fo
Autor:
J. Milburn Jessup, Stanley R. Hamilton, Elizabeth A. Mansfield, Gary J. Kelloff, Margaret Piper, Felix W. Frueh, Caroline C. Sigman, David R. Parkinson, Patricia A. Deverka, Lisa M. McShane, Robert T. McCormack, Susan M. Keating, Sean R. Tunis, Steven Gutman
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 20(6)
This article defines and describes best practices for the academic and business community to generate evidence of clinical utility for cancer molecular diagnostic assays. Beyond analytical and clinical validation, successful demonstration of clinical
Autor:
David Y. Jackson, H H Chiu, Susan M. Keating, Nicholas J. Skelton, M. E. Renz, Dean R. Artis, Cynthia P. Quan, Kevin R Clark, Maureen Beresini, Sherman Fong
Publikováno v:
Biopolymers. 47:265-275
Results from protein mutagenesis and x-ray crystallographic studies of the multidomain protein Vascular Cell Adhesion Molecule (VCAM) were used to design cyclic octapeptides that retain the critical structural and binding elements of the epitope of V
Autor:
Lisa D. Stefanich, Kevin R Clark, Thomas R. Gadek, Maureen Beresini, Susan M. Keating, Caroline P. Edwards, Fred Arellano, Sarah C. Bodary, Steven A. Spencer, James C. Marsters
Publikováno v:
Protein science : a publication of the Protein Society. 15(2)
The lymphocyte function-associated antigen-1 (LFA-1) binding of a unique class of small-molecule antagonists as represented by compound 3 was analyzed in comparison to that of soluble intercellular adhesion molecule-1 (sICAM-1) and A-286982, which re
Autor:
Georgette M, Castanedo, Fredrick C, Sailes, Nathan J P, Dubree, John B, Nicholas, Lisa, Caris, Kevin, Clark, Susan M, Keating, Maureen H, Beresini, Henry, Chiu, Sherman, Fong, James C, Marsters, David Y, Jackson, Daniel P, Sutherlin
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(20)
Two structural classes of dual alpha4beta1/alpha4beta7 integrin antagonists were investigated via solid-phase parallel synthesis. Using an acylated amino acid backbone, lead compounds containing biphenylalanine or tyrosine carbamate scaffolds were op