Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Susan M. Goebel"'
Autor:
Sara E. Royston, Paul J. Lombroso, Evan D. Wilson-Wallis, Janice R. Naegele, Susan M. Goebel-Goody, Stephanie Tagliatela
Publikováno v:
Genes, Brain and Behavior. 11:586-600
Fragile X syndrome (FXS), the most common inherited form of intellectual disability and prevailing known genetic basis of autism, is caused by an expansion in the Fmr1 gene that prevents transcription and translation of fragile X mental retardation p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c50eb87df64910936f7b0eabd8119824
https://doi.org/10.1111/j.1601-183x.2012.00781.x
https://doi.org/10.1111/j.1601-183x.2012.00781.x
Autor:
Pradeep Kurup, Stephanie M. Fernandez, Niki C. Carty, Constantinos D. Paspalas, Susan M. Goebel-Goody, Matthew L. Baum, Paul J. Lombroso
Publikováno v:
Pharmacological Reviews. 64:65-87
Striatal-enriched protein tyrosine phosphatase (STEP) is a brain-specific phosphatase that modulates key signaling molecules involved in synaptic plasticity and neuronal function. Targets include extracellular-regulated kinase 1 and 2 (ERK1/2), stres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f2fc3bc2b642caa2cc47f336b04a12d
https://doi.org/10.1124/pr.110.003053
https://doi.org/10.1124/pr.110.003053
Autor:
Peter H. Wu, Yongfang Zhang, Pradeep Kurup, James A. Bibb, Jian Xu, Ammar H. Hawasli, Paul J. Lombroso, Matthew L. Baum, Susan M. Goebel-Goody
Publikováno v:
The Journal of Neuroscience. 29:9330-9343
NMDA receptor (NMDAR)-mediated excitotoxicity plays an important role in several CNS disorders, including epilepsy, stroke, and ischemia. Here we demonstrate the involvement of striatal-enriched protein tyrosine phosphatase (STEP) in this critical pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d417b620d7cf1624bcc726522288911c
https://doi.org/10.1523/jneurosci.2212-09.2009
https://doi.org/10.1523/jneurosci.2212-09.2009
Autor:
Deepa V. Venkitaramani, Joanna Mattis, Constantinos D. Paspalas, Paul J. Lombroso, Pradeep Kurup, Susan M. Goebel-Goody, Yongfang Zhang, Casey C. Perley
Publikováno v:
Cerebral Cortex. 19:1666-1677
Major Vault Protein (MVP), the main constituent of the vault ribonucleoprotein particle, is highly conserved in eukaryotic cells and upregulated in a variety of tumors. Vaults have been speculated to function as cargo transporters in several cell lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5ef817e369fbd4a8e59304f42136f84
https://doi.org/10.1093/cercor/bhn203
https://doi.org/10.1093/cercor/bhn203
Autor:
Jadwiga Turchan-Cholewo, Shreya Buch, Susan M. Goebel, Indrapal N. Singh, Kurt F. Hauser, Pamela E. Knapp, Valeriya K. Khurdayan, Sarah E. Lutz, Avindra Nath, Nazira El-Hage
Publikováno v:
European Journal of Neuroscience. 19:3171-3182
Human immunodeficiency virus (HIV)-1 infection can cause characteristic neural defects such as progressive motor dysfunction, striatal pathology and gliosis. Recent evidence suggests that HIV-induced pathogenesis is exacerbated by heroin abuse and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dff35c9f68189ed8fa8d107cfc4efb51
https://doi.org/10.1111/j.0953-816x.2004.03461.x
https://doi.org/10.1111/j.0953-816x.2004.03461.x
Autor:
Ronald K. Freund, Paulo Renato A.V. Correa, Paul J. Lombroso, Richard A. Radcliffe, Tianna R. Hicklin, Susan M. Goebel-Goody, Michael Browning, William R. Proctor, P. H. Wu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 108(16)
Alcohol's deleterious effects on memory are well known. Acute alcohol-induced memory loss is thought to occur via inhibition of NMDA receptor (NMDAR)-dependent long-term potentiation in the hippocampus. We reported previously that ethanol inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8585911ea4ddecf22852989b86129579
https://pubmed.ncbi.nlm.nih.gov/21464302
https://pubmed.ncbi.nlm.nih.gov/21464302
Striatal Enriched Protein Tyrosine Phosphatase mediates Ethanol inhibition of NMDA Receptor Activity
Autor:
Michael Browning, Peter H. Wu, William R. Proctor, Susan M. Goebel-Goody, Paul J. Lombroso, Ronald K. Freund
Publikováno v:
Nature Precedings
We demonstrated previously that ethanol inhibition of NMDA receptor (NMDAR) function is accompanied by a reduction in tyrosine phosphorylation of Tyr^1472^ on the NR2B subunit, and this action of ethanol is attenuated by a broad spectrum tyrosine pho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a420eaaf367df6598fa2ab61f0d43662
http://precedings.nature.com/documents/2473/version/1
http://precedings.nature.com/documents/2473/version/1
Publikováno v:
The Journal of biological chemistry. 283(48)
Long lasting changes in the strength of synaptic transmission in the hippocampus are thought to underlie certain forms of learning and memory. Accordingly, the molecular mechanisms that account for these changes are heavily studied. Postsynaptically,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c5fbf9ffe2203ac26505173e0253778
https://pubmed.ncbi.nlm.nih.gov/18819923
https://pubmed.ncbi.nlm.nih.gov/18819923
Publikováno v:
Brain research. Molecular brain research. 142(1)
Hippocampal N-methyl-D-aspartate receptors (NMDARs) contribute to the expression of certain types of synaptic plasticity, such as long-term potentiation (LTP). It is well documented that tyrosine kinases increase NMDAR phosphorylation and potentiate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23a3da26cc0e70a1916f55ecfd6a24c3
https://pubmed.ncbi.nlm.nih.gov/16257472
https://pubmed.ncbi.nlm.nih.gov/16257472
Autor:
Valeriya K, Khurdayan, Shreya, Buch, Nazira, El-Hage, Sarah E, Lutz, Susan M, Goebel, Indrapal N, Singh, Pamela E, Knapp, Jadwiga, Turchan-Cholewo, Avindra, Nath, Kurt F, Hauser
Publikováno v:
The European journal of neuroscience. 19(12)
Human immunodeficiency virus-1 (HIV) infection can cause characteristic neural defects such as progressive motor dysfunction, striatal pathology, and gliosis. Recent evidence suggests that HIV-induced pathogenesis is exacerbated by heroin abuse and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6036273be5cd75e69b1a13a9ff5f052f
https://pubmed.ncbi.nlm.nih.gov/15217373
https://pubmed.ncbi.nlm.nih.gov/15217373