Zobrazeno 1 - 10
of 161
pro vyhledávání: '"Susan M. Farrington"'
Autor:
Zhishan Chen, Xingyi Guo, Ran Tao, Jeroen R. Huyghe, Philip J. Law, Ceres Fernandez-Rozadilla, Jie Ping, Guochong Jia, Jirong Long, Chao Li, Quanhu Shen, Yuhan Xie, Maria N. Timofeeva, Minta Thomas, Stephanie L. Schmit, Virginia Díez-Obrero, Matthew Devall, Ferran Moratalla-Navarro, Juan Fernandez-Tajes, Claire Palles, Kitty Sherwood, Sarah E. W. Briggs, Victoria Svinti, Kevin Donnelly, Susan M. Farrington, James Blackmur, Peter G. Vaughan-Shaw, Xiao-Ou Shu, Yingchang Lu, Peter Broderick, James Studd, Tabitha A. Harrison, David V. Conti, Fredrick R. Schumacher, Marilena Melas, Gad Rennert, Mireia Obón-Santacana, Vicente Martín-Sánchez, Jae Hwan Oh, Jeongseon Kim, Sun Ha Jee, Keum Ji Jung, Sun-Seog Kweon, Min-Ho Shin, Aesun Shin, Yoon-Ok Ahn, Dong-Hyun Kim, Isao Oze, Wanqing Wen, Keitaro Matsuo, Koichi Matsuda, Chizu Tanikawa, Zefang Ren, Yu-Tang Gao, Wei-Hua Jia, John L. Hopper, Mark A. Jenkins, Aung Ko Win, Rish K. Pai, Jane C. Figueiredo, Robert W. Haile, Steven Gallinger, Michael O. Woods, Polly A. Newcomb, David Duggan, Jeremy P. Cheadle, Richard Kaplan, Rachel Kerr, David Kerr, Iva Kirac, Jan Böhm, Jukka-Pekka Mecklin, Pekka Jousilahti, Paul Knekt, Lauri A. Aaltonen, Harri Rissanen, Eero Pukkala, Johan G. Eriksson, Tatiana Cajuso, Ulrika Hänninen, Johanna Kondelin, Kimmo Palin, Tomas Tanskanen, Laura Renkonen-Sinisalo, Satu Männistö, Demetrius Albanes, Stephanie J. Weinstein, Edward Ruiz-Narvaez, Julie R. Palmer, Daniel D. Buchanan, Elizabeth A. Platz, Kala Visvanathan, Cornelia M. Ulrich, Erin Siegel, Stefanie Brezina, Andrea Gsur, Peter T. Campbell, Jenny Chang-Claude, Michael Hoffmeister, Hermann Brenner, Martha L. Slattery, John D. Potter, Kostas K. Tsilidis, Matthias B. Schulze, Marc J. Gunter, Neil Murphy, Antoni Castells, Sergi Castellví-Bel, Leticia Moreira, Volker Arndt, Anna Shcherbina, D. Timothy Bishop, Graham G. Giles, Melissa C. Southey, Gregory E. Idos, Kevin J. McDonnell, Zomoroda Abu-Ful, Joel K. Greenson, Katerina Shulman, Flavio Lejbkowicz, Kenneth Offit, Yu-Ru Su, Robert Steinfelder, Temitope O. Keku, Bethany van Guelpen, Thomas J. Hudson, Heather Hampel, Rachel Pearlman, Sonja I. Berndt, Richard B. Hayes, Marie Elena Martinez, Sushma S. Thomas, Paul D. P. Pharoah, Susanna C. Larsson, Yun Yen, Heinz-Josef Lenz, Emily White, Li Li, Kimberly F. Doheny, Elizabeth Pugh, Tameka Shelford, Andrew T. Chan, Marcia Cruz-Correa, Annika Lindblom, David J. Hunter, Amit D. Joshi, Clemens Schafmayer, Peter C. Scacheri, Anshul Kundaje, Robert E. Schoen, Jochen Hampe, Zsofia K. Stadler, Pavel Vodicka, Ludmila Vodickova, Veronika Vymetalkova, Christopher K. Edlund, W. James Gauderman, David Shibata, Amanda Toland, Sanford Markowitz, Andre Kim, Stephen J. Chanock, Franzel van Duijnhoven, Edith J. M. Feskens, Lori C. Sakoda, Manuela Gago-Dominguez, Alicja Wolk, Barbara Pardini, Liesel M. FitzGerald, Soo Chin Lee, Shuji Ogino, Stephanie A. Bien, Charles Kooperberg, Christopher I. Li, Yi Lin, Ross Prentice, Conghui Qu, Stéphane Bézieau, Taiki Yamaji, Norie Sawada, Motoki Iwasaki, Loic Le Marchand, Anna H. Wu, Chenxu Qu, Caroline E. McNeil, Gerhard Coetzee, Caroline Hayward, Ian J. Deary, Sarah E. Harris, Evropi Theodoratou, Stuart Reid, Marion Walker, Li Yin Ooi, Ken S. Lau, Hongyu Zhao, Li Hsu, Qiuyin Cai, Malcolm G. Dunlop, Stephen B. Gruber, Richard S. Houlston, Victor Moreno, Graham Casey, Ulrike Peters, Ian Tomlinson, Wei Zheng
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Genome-wide association studies (GWAS) have identified more than 200 common genetic variants independently associated with colorectal cancer (CRC) risk, but the causal variants and target genes are mostly unknown. We sought to fine-map all k
Externí odkaz:
https://doaj.org/article/a9c9d74556364a62b1ef09719244a952
Autor:
Bradley T. Harris, Vidya Rajasekaran, James P. Blackmur, Alan O’Callaghan, Kevin Donnelly, Maria Timofeeva, Peter G. Vaughan-Shaw, Farhat V. N. Din, Malcolm G. Dunlop, Susan M. Farrington
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Colorectal cancer (CRC) is characterised by heritable risk that is not well understood. Heritable, genetic variation at 11q23.1 is associated with increased colorectal cancer (CRC) risk, demonstrating eQTL effects on 3 cis- and 23 trans-eQTL
Externí odkaz:
https://doaj.org/article/7c17f60afc49461995adda03084f6bcb
Autor:
James P. Blackmur, Peter G. Vaughan-Shaw, Kevin Donnelly, Bradley T. Harris, Victoria Svinti, Anna-Maria Ochocka-Fox, Paz Freile, Marion Walker, Toby Gurran, Stuart Reid, Colin A. Semple, Farhat V. N. Din, Maria Timofeeva, Malcolm G. Dunlop, Susan M. Farrington
Publikováno v:
Frontiers in Genetics, Vol 12 (2022)
Colorectal cancer (CRC) is a common, multifactorial disease. While observational studies have identified an association between lower vitamin D and higher CRC risk, supplementation trials have been inconclusive and the mechanisms by which vitamin D m
Externí odkaz:
https://doaj.org/article/686e8d86035a450290be3bc78efa9387
Autor:
Marion Bacou, Vidya Rajasekaran, Adrian Thomson, Sandra Sjöstrand, Katarzyna Kaczmarek, Anna Maria Ochocka-Fox, Adam D. Gerrard, Susan Moug, Tomas Jansson, Helen Mulvana, Carmel M. Moran, Susan M. Farrington
Publikováno v:
Cancers, Vol 14, Iss 3, p 561 (2022)
Lymph nodes (LNs) are believed to be the first organs targeted by colorectal cancer cells detached from a primary solid tumor because of their role in draining interstitial fluids. Better detection and assessment of these organs have the potential to
Externí odkaz:
https://doaj.org/article/fe62a76b31b74abfa30594fd4e3c60a7
Autor:
Yazhou He, Maria Timofeeva, Susan M. Farrington, Peter Vaughan-Shaw, Victoria Svinti, Marion Walker, Lina Zgaga, Xiangrui Meng, Xue Li, Athina Spiliopoulou, Xia Jiang, Elina Hyppönen, Peter Kraft, Douglas P. Kiel, The SUNLIGHT consortium, Caroline Hayward, Archie Campbell, David Porteous, Katarina Vucic, Iva Kirac, Masa Filipovic, Sarah E. Harris, Ian J. Deary, Richard Houlston, Ian P. Tomlinson, Harry Campbell, Evropi Theodoratou, Malcolm G. Dunlop
Publikováno v:
BMC Medicine, Vol 16, Iss 1, Pp 1-11 (2018)
Abstract Background Whilst observational studies establish that lower plasma 25-hydroxyvitamin D (25-OHD) levels are associated with higher risk of colorectal cancer (CRC), establishing causality has proven challenging. Since vitamin D is modifiable,
Externí odkaz:
https://doaj.org/article/2e585081cd6640a084a34922f53c7e06
Autor:
Xia Jiang, Paul F. O’Reilly, Hugues Aschard, Yi-Hsiang Hsu, J. Brent Richards, Josée Dupuis, Erik Ingelsson, David Karasik, Stefan Pilz, Diane Berry, Bryan Kestenbaum, Jusheng Zheng, Jianan Luan, Eleni Sofianopoulou, Elizabeth A. Streeten, Demetrius Albanes, Pamela L. Lutsey, Lu Yao, Weihong Tang, Michael J. Econs, Henri Wallaschofski, Henry Völzke, Ang Zhou, Chris Power, Mark I. McCarthy, Erin D. Michos, Eric Boerwinkle, Stephanie J. Weinstein, Neal D. Freedman, Wen-Yi Huang, Natasja M. Van Schoor, Nathalie van der Velde, Lisette C. P. G. M. de Groot, Anke Enneman, L. Adrienne Cupples, Sarah L. Booth, Ramachandran S. Vasan, Ching-Ti Liu, Yanhua Zhou, Samuli Ripatti, Claes Ohlsson, Liesbeth Vandenput, Mattias Lorentzon, Johan G. Eriksson, M. Kyla Shea, Denise K. Houston, Stephen B. Kritchevsky, Yongmei Liu, Kurt K. Lohman, Luigi Ferrucci, Munro Peacock, Christian Gieger, Marian Beekman, Eline Slagboom, Joris Deelen, Diana van Heemst, Marcus E. Kleber, Winfried März, Ian H. de Boer, Alexis C. Wood, Jerome I. Rotter, Stephen S. Rich, Cassianne Robinson-Cohen, Martin den Heijer, Marjo-Riitta Jarvelin, Alana Cavadino, Peter K. Joshi, James F. Wilson, Caroline Hayward, Lars Lind, Karl Michaëlsson, Stella Trompet, M. Carola Zillikens, Andre G. Uitterlinden, Fernando Rivadeneira, Linda Broer, Lina Zgaga, Harry Campbell, Evropi Theodoratou, Susan M. Farrington, Maria Timofeeva, Malcolm G. Dunlop, Ana M. Valdes, Emmi Tikkanen, Terho Lehtimäki, Leo-Pekka Lyytikäinen, Mika Kähönen, Olli T. Raitakari, Vera Mikkilä, M. Arfan Ikram, Naveed Sattar, J. Wouter Jukema, Nicholas J. Wareham, Claudia Langenberg, Nita G. Forouhi, Thomas E. Gundersen, Kay-Tee Khaw, Adam S. Butterworth, John Danesh, Timothy Spector, Thomas J. Wang, Elina Hyppönen, Peter Kraft, Douglas P. Kiel
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Vitamin D deficiency is associated with multiple human pathologic conditions. In a genome-wide association study of 79,366 individuals, Jiang et al. replicate four and identify two new genetic loci for serum levels of 25-hydroxyvitamin D and find evi
Externí odkaz:
https://doaj.org/article/45ceebb3cb0e4473b2cfdeb800d4099c
Autor:
Ben Kinnersley, Daniel Chubb, Sara E. Dobbins, Matthew Frampton, Stephan Buch, Maria N. Timofeeva, Sergi Castellví-Bel, Susan M. Farrington, Asta Forsti, Jochen Hampe, Kari Hemminki, Robert M. W. Hofstra, Emma Northwood, Claire Palles, Manuela Pinheiro, Clara Ruiz-Ponte, Clemens Schafmayer, Manuel R. Teixeira, Helga Westers, Tom van Wezel, D. Timothy Bishop, Ian Tomlinson, Malcolm G. Dunlop, Richard S. Houlston
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-3 (2016)
Externí odkaz:
https://doaj.org/article/3995a0ed53f04657ae7904007a97225c
Autor:
Wanxin Li, Xuan Zhou, Shuai Yuan, Lijuan Wang, Lili Yu, Jing Sun, Jie Chen, Qian Xiao, Zhongxiao Wan, Ju-Sheng Zheng, Cai-Xia Zhang, Susanna C. Larsson, Susan M. Farrington, Philip Law, Richard S. Houlston, Ian Tomlinson, Ke-Feng Ding, Malcolm G. Dunlop, Evropi Theodoratou, Xue Li
Publikováno v:
Li, W, Zhou, X, Yuan, S, Wang, L, Sun, J, Chen, J, Xiao, Q, Wan, Z, Zheng, J, Zhang, C-X, Larsson, S C, Farrington, S M, Law, P, Houlston, R S, Tomlinson, I, Ding, K-F, Dunlop, M G, Theodoratou, E & Li, X 2023, ' Exploring the complex relationship between gut microbiota and risk of colorectal neoplasia using bidirectional Mendelian Randomization analysis ', Cancer Epidemiology, Biomarkers & Prevention, vol. 32, no. 6, pp. 809-817 . https://doi.org/10.1158/1055-9965.EPI-22-0724
Background: Human gut microbiome has complex relationships with the host, contributing to metabolism, immunity, and carcinogenesis. Methods: Summary-level data for gut microbiota and metabolites were obtained from MiBioGen, FINRISK and human metabolo
Autor:
Xue Li, Evropi Theodoratou, Malcolm G. Dunlop, Ke-Feng Ding, Ian Tomlinson, Richard S. Houlston, Philip Law, Susan M. Farrington, Susanna C. Larsson, Cai-Xia Zhang, Ju-Sheng Zheng, Zhongxiao Wan, Qian Xiao, Jie Chen, Jing Sun, Lili Yu, Lijuan Wang, Shuai Yuan, Xuan Zhou, Wanxin Li
Table S4 shows the SNPs for colorectal cancer.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f3fbddedbbcc6d6ffbca6f23a01cd16
https://doi.org/10.1158/1055-9965.22658591
https://doi.org/10.1158/1055-9965.22658591
Autor:
Xue Li, Evropi Theodoratou, Malcolm G. Dunlop, Ke-Feng Ding, Ian Tomlinson, Richard S. Houlston, Philip Law, Susan M. Farrington, Susanna C. Larsson, Cai-Xia Zhang, Ju-Sheng Zheng, Zhongxiao Wan, Qian Xiao, Jie Chen, Jing Sun, Lili Yu, Lijuan Wang, Shuai Yuan, Xuan Zhou, Wanxin Li
Supplementary Methods shows the formulas for calculating F-statistics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::198d8452bad33a499a5506a45d5a7f2b
https://doi.org/10.1158/1055-9965.22658606.v1
https://doi.org/10.1158/1055-9965.22658606.v1