Výsledky vyhledávání - "Susan M. Aronica"

Antitumor/Antiestrogenic Effect of the Chemokine Interferon Inducible Protein 10 (IP-10) Involves Suppression of VEGF Expression in Mammary Tissue

Autor: Caroline Kisela, Susan M. Aronica, Michael Hanzly, Lisa Raiber

Publikováno v: Journal of Interferon & Cytokine Research. 29:83-92

Vascular endothelial growth factor (VEGF) promotes angiogenesis in a number of tumor model systems. We reported previously that estrogen supports the growth of CCL-51 cell-based mammary tumors in mice, which could be blocked with specific chemokines.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d55a38bf9ff369bab6338990dfde5a5
https://doi.org/10.1089/jir.2008.0034

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Estrogen and tamoxifen up-regulate FXYD3 on breast cancer cells: assessing the differential roles of ER α and ZEB1

Autor: Paul Herrmann, Susan M. Aronica

Publikováno v: SpringerPlus

Increased expression of the FXYD3 family of proteins has been associated with lung, colorectal, bladder and pancreatic cancers, and recent evidence suggests that elevated FXYD3 may promote tumor cell proliferation in breast cancer as well. However, f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0a5e1331a85ac6cab69015295c0321b
https://doi.org/10.1186/s40064-015-1022-7

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Estrogen Disrupts Chemokine-Mediated Chemokine Release from Mammary Cells: Implications for the Interplay between Estrogen and IP-10 in the Regulation of Mammary Tumor Formation

Autor: Susan M. Aronica, K. Gibbs, K. Kaminskaya, K. Grzybek, Robert Bucelli, K. Janis, P. Fanti, Lisa Raiber, C. Schwach, M. Mineo, M. Nazareth, K. Poppenberg, M. Kumin

Publikováno v: Breast Cancer Research and Treatment. 84:235-245

Chemokines are pro-inflammatory cytokines that function to attract immune cells to the sites of tissue inflammation, injury or infection. We have formulated the hypothesis that release of one chemokine can serve, in a local paracrine or endocrine fas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79332f0004bff547108b914af0b2eea3
https://doi.org/10.1023/b:brea.0000019961.59306.f6

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Estrogen Decreases Expression of Chemokine Receptors, and Suppresses Chemokine Bioactivity in Murine Monocytes

Autor: Susan M. Aronica, P. Fanti, M. Nazareth, K. Poppenberg, Janice Hoeltke, K. Janis

Publikováno v: American Journal of Reproductive Immunology. 51:22-31

Problem: We propose that the ability of estrogen exposure to increase the probability of a woman developing breast cancer may be related to decreased chemokine activity and suppression of immune surveillance in mammary tissue. The present study was c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a229833abbab82c2c62bd48bad5ca885
https://doi.org/10.1046/j.8755-8920.2003.00117.x

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Altered Bax expression and decreased apoptosis in bone marrow cells of lupus-susceptible NZB/W mice

Autor: C. Schwach, M. Nazareth, P. Fanti, Susan M. Aronica, K. Poppenberg, K. Janis

Publikováno v: Lupus. 10:785-793

Estrogen is believed to contribute to the development of the autoimmune disorder systemic lupus erythematosus (SLE) (lupus) in women. We hypothesized that estrogen might promote the development of lupus by altering apoptosis of bone marrow cells, per

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d432b419b508b4ed0e78a73d41762824
https://doi.org/10.1177/096120330101001105

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Altered bone marrow cell sensitivity in the lupus-prone NZB/W mouse: regulation of CFU-GM colony formation by estrogen, tamoxifen and thrombopoietin

Autor: M. Nazareth, Susan M. Aronica, A Dozier, P. Fanti

Publikováno v: Lupus. 9:271-277

Estrogen is thought to contribute to the onset of systemic lupus erythematosus (SLE) in women through mechanisms that are not completely understood. Although estrogen serves as a negative regulator in normal hematopoietic development, little research

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00997f44d6010f863a316e2af1e1db6b
https://doi.org/10.1191/096120300680198962

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Macrophage Inflammatory Protein-1α and Interferon-Inducible Protein 10 Inhibit Synergistically Induced Growth Factor Stimulation of MAP Kinase Activity and Suppress Phosphorylation of Eukaryotic Initiation Factor 4E and 4E Binding Protein 1

Autor: Susan M. Aronica, Anne-Claude Gingras, Nahum Sonenberg, Scott Cooper, Nancy Hague, Hal E. Broxmeyer

Publikováno v: Blood. 89:3582-3595

Granulocyte-macrophage colony-stimulating factor (GM-CSF ) and Steel factor (SLF ) synergistically stimulate Raf-1 kinase activity, protein synthesis, and proliferation in hematopoietic MO7e cells; synergistic action of these factors is blocked by th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9028234ad7b06b828d66b97be8b294c6
https://doi.org/10.1182/blood.v89.10.3582

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Biology and mechanisms of action of synergistically stimulated myeloid progenitor cell proliferation and suppression by chemokines

Autor: Hal E. Broxmeyer, Charlie Mantel, Susan M. Aronica

Publikováno v: Stem Cells. 15:69-78

A number of cytokines can act together to stimulate/enhance the proliferation of hematopoietic stem and progenitor cells in a greater than additive fashion. An example of this is the combination of a colony-stimulating factor with a potent costimulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3451766441d5dc271a6fe9de2a032a6e
https://doi.org/10.1002/stem.5530150811

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Advances in understanding the postreceptor mechanisms of action of GM-CSF, G-CSF, and Steel factor

Autor: Hal E. Broxmeyer, Susan M. Aronica

Publikováno v: Current Opinion in Hematology. 3:185-190

Intracellular signaling events occurring downstream of receptor activation for the colony-stimulating factors GM-CSF and G-CSF and Steel factor the latter a member of the tyrosine kinase receptor family of hematopoietic growth factors, are discussed.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8a89a11d19b397373fe0c6ed4c37186
https://doi.org/10.1097/00062752-199603030-00004

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