Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Susan M Wall"'
Autor:
Hyun Jun Jung, Truyen D. Pham, Xiao-Tong Su, Teodora Veronica Grigore, Joost G. Hoenderop, Hannes Olauson, Susan M. Wall, David H. Ellison, Paul A. Welling, Lama Al-Qusairi
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Klotho regulates many pathways in the aging process, but it remains unclear how it is physiologically regulated. Because Klotho is synthesized, cleaved, and released from the kidney; activates the chief urinary K+ secretion channel (ROMK) an
Externí odkaz:
https://doaj.org/article/5dee2c3598f648a49e6f76465874f247
Autor:
Roy L Sutliff, Erik R Walp, Young Hee Kim, Lori A Walker, Alexander M El-Ali, Jing Ma, Robert Bonsall, Semra Ramosevac, Douglas C Eaton, Jill W Verlander, Laura Hansen, Rudolph L Gleason, Truyen D Pham, Seongun Hong, Vladimir Pech, Susan M Wall
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105101 (2014)
Pendrin is a Cl-/HCO3- exchanger expressed in the apical regions of renal intercalated cells. Following pendrin gene ablation, blood pressure falls, in part, from reduced renal NaCl absorption. We asked if pendrin is expressed in vascular tissue and
Externí odkaz:
https://doaj.org/article/bb1451a941eb423ba64bad8a0b856ab8
Publikováno v:
American Journal of Physiology-Cell Physiology. 324:C1171-C1178
KCC3a expression is stimulated in alkalemia. This paper shows that bicarbonate itself is mediating this effect through a posttranscriptional mechanism. The paper also shows that this phenomenon is not mediated by aldosterone or angiotensin II.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9339c492c765aa24428c3124a92d7998
https://doi.org/10.1152/ajpcell.00094.2023
https://doi.org/10.1152/ajpcell.00094.2023
Publikováno v:
American Journal of Physiology-Renal Physiology. 324:F12-F29
The renal response to acid-base disturbances involves phenotypic and remodeling changes in the collecting duct. This study examines whether the proximal tubule controls these responses. We examined mice with genetic deletion of proteins present only
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eaf50554e419874c2725cc83c47471a
https://doi.org/10.1152/ajprenal.00175.2022
https://doi.org/10.1152/ajprenal.00175.2022
Autor:
Susan M. Wall
Publikováno v:
Kidney Research and Clinical Practice, Vol 36, Iss 4, Pp 305-317 (2017)
Type B and non-A, non-B intercalated cells are found within the connecting tubule and the cortical collecting duct. Of these cell types, type B intercalated cells are known to mediate Cl⁻ absorption and HCO₃⁻ secretion largely through pendrin-d
Externí odkaz:
https://doaj.org/article/0312df0a4c104ff498c249f20559cc84
Autor:
Truyen D, Pham, Anthony J, Elengickal, Jill W, Verlander, Lama, Al-Qusairi, Chao, Chen, Delaney C, Abood, Spencer A, King, Johannes, Loffing, Paul A, Welling, Susan M, Wall
Publikováno v:
Am J Physiol Renal Physiol
Pendrin is an intercalated cell Cl(−)/ [Formula: see text] exchanger thought to participate in K(+)-sparing NaCl absorption. However, its role in K(+) homeostasis has not been clearly defined. We hypothesized that pendrin-null mice will develop hyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::42e31d5db60909a092df1d5625d8d4b5
https://pubmed.ncbi.nlm.nih.gov/35224991
https://pubmed.ncbi.nlm.nih.gov/35224991
Autor:
Truyen D. Pham, Anthony J. Elengickal, Jill W. Verlander, Lama Al-Qusairi, Chao Chen, Delaney C. Abood, Spencer A. King, Johannes Loffing, Paul A. Welling, Susan M. Wall
Publikováno v:
American Journal of Physiology-Renal Physiology. 322:F486-F497
Pendrin is an apical Cl−/[Formula: see text] exchanger that provides renal K+-sparing NaCl absorption. The pendrin-null kidney has an inability to fully conserve K+ and limits renal K+ loss by downregulating the epithelial Na+ channel (ENaC). Howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f42201900b5ff1d3b1e4cf0954a141f7
https://doi.org/10.1152/ajprenal.00378.2021
https://doi.org/10.1152/ajprenal.00378.2021
Autor:
Susan M. Wall
Publikováno v:
Hypertension. 79:706-716
Intercalated cells make up about a third of all cells within the connecting tubule and the collecting duct and are subclassified as type A, type B and non-A, non-B based on the subcellular distribution of the H + -ATPase, which dictates whether it se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1dae982e92ff994d0272980d18f3cea9
https://doi.org/10.1161/hypertensionaha.121.16492
https://doi.org/10.1161/hypertensionaha.121.16492
Publikováno v:
Clin J Am Soc Nephrol
Background and objectives Although US physician-scientists have made enormous contributions to biomedical research, this workforce is thought to be getting smaller. However, among kidney researchers, changes have not been fully quantified. Design, se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::936a057370fde67f7d3142b8427799ce
https://doi.org/10.2215/cjn.02440221
https://doi.org/10.2215/cjn.02440221
Autor:
Douglas C. Eaton, Cesar A. Romero, Jill W. Verlander, Truyen D. Pham, Yanhua Wang, Qiang Yue, Yoskaly Lazo-Fernandez, Chao Chen, Monika Thumova, Susan M. Wall
Publikováno v:
J Am Soc Nephrol
Background Aldosterone activates the intercalated cell mineralocorticoid receptor, which is enhanced with hypokalemia. Whether this receptor directly regulates the intercalated cell chloride/bicarbonate exchanger pendrin is unclear, as are potassium'
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b41c366e1608b1e2a9e8fb4bc433995a
https://doi.org/10.1681/asn.2019050551
https://doi.org/10.1681/asn.2019050551