Zobrazeno 1 - 10
of 669
pro vyhledávání: '"Susan M Resnick"'
Autor:
Richard F Oppong, Antonio Terracciano, Martin Picard, Yong Qian, Thomas J Butler, Toshiko Tanaka, Ann Zenobia Moore, Eleanor M Simonsick, Krista Opsahl-Ong, Christopher Coletta, Angelina R Sutin, Myriam Gorospe, Susan M Resnick, Francesco Cucca, Sonja W Scholz, Bryan J Traynor, David Schlessinger, Luigi Ferrucci, Jun Ding
Publikováno v:
eLife, Vol 11 (2022)
Background: Mitochondrial DNA copy number (mtDNAcn) in tissues and blood can be altered in conditions like diabetes and major depression and may play a role in aging and longevity. However, little is known about the association between mtDNAcn and pe
Externí odkaz:
https://doaj.org/article/64ebb18f36834dd8a52e9975164dd757
Autor:
Diana Younan, Xinhui Wang, Joshua Millstein, Andrew J Petkus, Daniel P Beavers, Mark A Espeland, Helena C Chui, Susan M Resnick, Margaret Gatz, Joel D Kaufman, Gregory A Wellenius, Eric A Whitsel, JoAnn E Manson, Stephen R Rapp, Jiu-Chiuan Chen
Publikováno v:
PLoS Medicine, Vol 19, Iss 2, p e1003893 (2022)
BackgroundLate-life exposure to ambient air pollution is a modifiable risk factor for dementia, but epidemiological studies have shown inconsistent evidence for cognitive decline. Air quality (AQ) improvement has been associated with improved cardiop
Externí odkaz:
https://doaj.org/article/64c248c6b1cc4ef28013c7ad068bf88e
Autor:
Vijay R Varma, Youjin Wang, Yang An, Sudhir Varma, Murat Bilgel, Jimit Doshi, Cristina Legido-Quigley, João C Delgado, Anup M Oommen, Jackson A Roberts, Dean F Wong, Christos Davatzikos, Susan M Resnick, Juan C Troncoso, Olga Pletnikova, Richard O'Brien, Eelko Hak, Brenda N Baak, Ruth Pfeiffer, Priyanka Baloni, Siamak Mohmoudiandehkordi, Kwangsik Nho, Rima Kaddurah-Daouk, David A Bennett, Shahinaz M Gadalla, Madhav Thambisetty
Publikováno v:
PLoS Medicine, Vol 18, Iss 5, p e1003615 (2021)
BackgroundWhile Alzheimer disease (AD) and vascular dementia (VaD) may be accelerated by hypercholesterolemia, the mechanisms underlying this association are unclear. We tested whether dysregulation of cholesterol catabolism, through its conversion t
Externí odkaz:
https://doaj.org/article/2c8a7f7dbbcf4006bcc57756f0be9c11
Autor:
Luigi Ferrucci, Mustapha Bouhrara, Joseph S R Alisch, Nikkita Khattar, Richard W Kim, Abinand C Rejimon, Luis E Cortina, Wenshu Qian, Susan M Resnick, Richard G Spencer
Publikováno v:
BMJ Neurology Open, Vol 2, Iss 1 (2020)
Background Myelin loss and cerebral blood flow (CBF) decline are central features of several neurodegenerative diseases. Myelin maintenance through oligodendrocyte metabolism is an energy-demanding process, so that myelin homeostasis is particularly
Externí odkaz:
https://doaj.org/article/73145046eb164f8a843f7b44b6f2f546
Autor:
Michael J Tisza, Diana V Pastrana, Nicole L Welch, Brittany Stewart, Alberto Peretti, Gabriel J Starrett, Yuk-Ying S Pang, Siddharth R Krishnamurthy, Patricia A Pesavento, David H McDermott, Philip M Murphy, Jessica L Whited, Bess Miller, Jason Brenchley, Stephan P Rosshart, Barbara Rehermann, John Doorbar, Blake A Ta'ala, Olga Pletnikova, Juan C Troncoso, Susan M Resnick, Ben Bolduc, Matthew B Sullivan, Arvind Varsani, Anca M Segall, Christopher B Buck
Publikováno v:
eLife, Vol 9 (2020)
Although millions of distinct virus species likely exist, only approximately 9000 are catalogued in GenBank's RefSeq database. We selectively enriched for the genomes of circular DNA viruses in over 70 animal samples, ranging from nematodes to human
Externí odkaz:
https://doaj.org/article/18258a977dad4b58af65b3c54e4dcb03
Autor:
Kurt G Schilling, Justin Blaber, Colin Hansen, Leon Cai, Baxter Rogers, Adam W Anderson, Seth Smith, Praitayini Kanakaraj, Tonia Rex, Susan M Resnick, Andrea T Shafer, Laurie E Cutting, Neil Woodward, David Zald, Bennett A Landman
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0236418 (2020)
Diffusion magnetic resonance images may suffer from geometric distortions due to susceptibility induced off resonance fields, which cause geometric mismatch with anatomical images and ultimately affect subsequent quantification of microstructural or
Externí odkaz:
https://doaj.org/article/0370be24fa574235bc4b9ce9bc22df1c
Autor:
Shikha Chaganti, Valerie F Welty, Warren Taylor, Kimberly Albert, Michelle D Failla, Carissa Cascio, Seth Smith, Louise Mawn, Susan M Resnick, Lori L Beason-Held, Francesca Bagnato, Thomas Lasko, Jeffrey D Blume, Bennett A Landman
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0225495 (2019)
Increasing reliance on electronic medical records at large medical centers provides unique opportunities to perform population level analyses exploring disease progression and etiology. The massive accumulation of diagnostic, procedure, and laborator
Externí odkaz:
https://doaj.org/article/40db8a159d4947589b4ff95881c5cb3b
Autor:
Keenan A. Walker, Yang An, Abhay Moghekar, Ruin Moaddel, Michael R. Duggan, Zhongsheng Peng, Qu Tian, Luke C. Pilling, Shannon M. Drouin, Mark A. Espeland, Stephen R Rapp, Kathleen M Hayden, Aladdin H. Shadyab, Ramon Casanova, Madhav Thambisetty, Peter R. Rapp, Dimitrios Kapogiannis, Luigi Ferrucci, Susan M. Resnick
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-18 (2024)
Abstract Background Apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late onset Alzheimer’s disease (AD). This case-cohort study used targeted plasma biomarkers and large-scale proteomics to examine the biological mechani
Externí odkaz:
https://doaj.org/article/ee7fd18cf0994326a5954b2b904a2e34
Autor:
Junhao Wen, Zhijian Yang, Ilya M. Nasrallah, Yuhan Cui, Guray Erus, Dhivya Srinivasan, Ahmed Abdulkadir, Elizabeth Mamourian, Gyujoon Hwang, Ashish Singh, Mark Bergman, Jingxuan Bao, Erdem Varol, Zhen Zhou, Aleix Boquet-Pujadas, Jiong Chen, Arthur W. Toga, Andrew J. Saykin, Timothy J. Hohman, Paul M. Thompson, Sylvia Villeneuve, Randy Gollub, Aristeidis Sotiras, Katharina Wittfeld, Hans J. Grabe, Duygu Tosun, Murat Bilgel, Yang An, Daniel S. Marcus, Pamela LaMontagne, Tammie L. Benzinger, Susan R. Heckbert, Thomas R. Austin, Lenore J. Launer, Mark Espeland, Colin L. Masters, Paul Maruff, Jurgen Fripp, Sterling C. Johnson, John C. Morris, Marilyn S. Albert, R. Nick Bryan, Susan M. Resnick, Luigi Ferrucci, Yong Fan, Mohamad Habes, David Wolk, Li Shen, Haochang Shou, Christos Davatzikos
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Alzheimer’s disease (AD) is associated with heterogeneous atrophy patterns. We employed a semi-supervised representation learning technique known as Surreal-GAN, through which we identified two latent dimensional representations of brain a
Externí odkaz:
https://doaj.org/article/56d631e8319148739bce0f8e8b35d005
Autor:
Mathilde Antoniades, Dhivya Srinivasan, Junhao Wen, Guray Erus, Ahmed Abdulkadir, Elizabeth Mamourian, Randa Melhem, Gyujoon Hwang, Yuhan Cui, Sindhuja Tirumalai Govindarajan, Andrew A. Chen, Zhen Zhou, Zhijian Yang, Jiong Chen, Raymond Pomponio, Susan Sotardi, Yang An, Murat Bilgel, Pamela LaMontagne, Ashish Singh, Tammie Benzinger, Lori Beason-Held, Daniel S. Marcus, Kristine Yaffe, Lenore Launer, John C. Morris, Duygu Tosun, Luigi Ferrucci, R. Nick Bryan, Susan M. Resnick, Mohamad Habes, David Wolk, Yong Fan, Ilya M. Nasrallah, Haochang Shou, Christos Davatzikos
Publikováno v:
EBioMedicine, Vol 109, Iss , Pp 105399- (2024)
Summary: Background: Brain ageing is highly heterogeneous, as it is driven by a variety of normal and neuropathological processes. These processes may differentially affect structural and functional brain ageing across individuals, with more pronounc
Externí odkaz:
https://doaj.org/article/782b783c1fc740c68d12c609c91452e4