Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Susan M Kitchen‐Goosen"'
Autor:
Maggie H Chasse, Benjamin K Johnson, Elissa A Boguslawski, Katie M Sorensen, Jessica E Rosien, Min H Kang, C Patrick Reynolds, Lyong Heo, Zachary B Madaj, Ian Beddows, Gabrielle E Foxa, Susan M Kitchen‐Goosen, Bart O Williams, Timothy J Triche, Patrick J Grohar
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 2, Pp 1-21 (2020)
Abstract Rhabdoid tumor (RT) is a pediatric cancer characterized by the inactivation of SMARCB1, a subunit of the SWI/SNF chromatin remodeling complex. Although this deletion is the known oncogenic driver, there are limited effective therapeutic opti
Externí odkaz:
https://doaj.org/article/18bf94a3ea2d4e32b5861a62e60c62a8
Autor:
Susan M Kitchen-Goosen, Heather Schumacher, Julie Good, Amanda L Patterson, Elissa A Boguslawski, Richard A West, Bart O Williams, Galen Hostetter, Dalen W Agnew, Jose M Teixeira, Arthur S Alberts
Publikováno v:
Carcinogenesis. 44:54-64
Loss of heterozygosity and promoter hypermethylation of APC is frequently observed in human endometrial cancer, which is the most common gynecological cancer in the USA, but its carcinogenic driver status in the endometrial epithelium has not been co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffb9850ead2631e82954d606211f3739
https://doi.org/10.1093/carcin/bgac101
https://doi.org/10.1093/carcin/bgac101
Autor:
Said Izreig, Alexandra Gariepy, Irem Kaymak, Hannah R. Bridges, Ariel O. Donayo, Gaëlle Bridon, Lisa M. DeCamp, Susan M. Kitchen-Goosen, Daina Avizonis, Ryan D. Sheldon, Rob C. Laister, Mark D. Minden, Nathalie A. Johnson, Thomas F. Duchaine, Marc S. Rudoltz, Sanghee Yoo, Michael N. Pollak, Kelsey S. Williams, Russell G. Jones
Publikováno v:
Cell Reports Medicine, Vol 1, Iss 2, Pp 100014- (2020)
Summary: Cancer cells display metabolic plasticity to survive stresses in the tumor microenvironment. Cellular adaptation to energetic stress is coordinated in part by signaling through the liver kinase B1 (LKB1)-AMP-activated protein kinase (AMPK) p
Externí odkaz:
https://doaj.org/article/d6a25ea75c0340f4b7b742c8469caad8
Autor:
Jenna M. Gedminas, Rebecca Kaufman, Elissa A. Boguslawski, Amy C. Gross, Marie Adams, Ian Beddows, Susan M. Kitchen-Goosen, Ryan D. Roberts, Patrick J. Grohar
Publikováno v:
Molecular Cancer Therapeutics. 21:1296-1305
Desmoplastic small round cell tumor (DSRCT) is a rare pediatric sarcoma with poor overall survival. This tumor is absolutely dependent on the continued expression and activity of its defining molecular lesion, the EWS–WT1 transcription factor. Unfo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfbd222714dfb30ea0b9a86716cb2076
https://doi.org/10.1158/1535-7163.mct-21-1003
https://doi.org/10.1158/1535-7163.mct-21-1003
Autor:
Shelby E. Compton, Susan M. Kitchen-Goosen, Lisa M. DeCamp, Kin H. Lau, Batsirai Mabvakure, Matthew Vos, Kelsey S. Williams, Kwok-Kin Wong, Xiaobing Shi, Scott B. Rothbart, Connie M. Krawczyk, Russell G. Jones
Publikováno v:
Molecular Cell.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e647b50ebcd27fc151a3acf4a8912712
https://doi.org/10.1016/j.molcel.2023.04.017
https://doi.org/10.1016/j.molcel.2023.04.017
Autor:
Patrick J. Grohar, Ryan D. Roberts, Susan M. Kitchen-Goosen, Ian Beddows, Marie Adams, Amy C. Gross, Elissa A. Boguslawski, Rebecca Kaufman, Jenna M. Gedminas
Supplementary Data from Lurbinectedin Inhibits the EWS–WT1 Transcription Factor in Desmoplastic Small Round Cell Tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48e2842c1e98c596b51f5fdb72e255b4
https://doi.org/10.1158/1535-7163.22523076.v1
https://doi.org/10.1158/1535-7163.22523076.v1
Autor:
Patrick J. Grohar, Ryan D. Roberts, Susan M. Kitchen-Goosen, Ian Beddows, Marie Adams, Amy C. Gross, Elissa A. Boguslawski, Rebecca Kaufman, Jenna M. Gedminas
Supplementary Figure from Lurbinectedin Inhibits the EWS–WT1 Transcription Factor in Desmoplastic Small Round Cell Tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14b0d6d1d59dc549dbf7b79609c23fae
https://doi.org/10.1158/1535-7163.22523073
https://doi.org/10.1158/1535-7163.22523073
Autor:
Patrick J. Grohar, Lee J. Helman, Natasha J. Caplen, Scott E. Martin, Susan M. Kitchen-Goosen, Carleen A. Klumpp-Thomas, Marie Adams, Sergey Dikalov, Ian Beddows, Zachary B. Madaj, Brandon M. Oswald, Elissa A. Boguslawski, Joel H. Everett, Guillermo Flores
Laboratory values
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::501062fa1daa46709fce14f79900fb92
https://doi.org/10.1158/1535-7163.22518997.v1
https://doi.org/10.1158/1535-7163.22518997.v1
Autor:
Patrick J. Grohar, Ryan D. Roberts, Susan M. Kitchen-Goosen, Ian Beddows, Marie Adams, Amy C. Gross, Elissa A. Boguslawski, Rebecca Kaufman, Jenna M. Gedminas
Desmoplastic small round cell tumor (DSRCT) is a rare pediatric sarcoma with poor overall survival. This tumor is absolutely dependent on the continued expression and activity of its defining molecular lesion, the EWS–WT1 transcription factor. Unfo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddf9a8820f4734ec5b31091379f70cb8
https://doi.org/10.1158/1535-7163.c.6543585.v1
https://doi.org/10.1158/1535-7163.c.6543585.v1
Autor:
Patrick J. Grohar, Lee J. Helman, Natasha J. Caplen, Scott E. Martin, Susan M. Kitchen-Goosen, Carleen A. Klumpp-Thomas, Marie Adams, Sergey Dikalov, Ian Beddows, Zachary B. Madaj, Brandon M. Oswald, Elissa A. Boguslawski, Joel H. Everett, Guillermo Flores
There is a need to develop novel approaches to improve the balance between efficacy and toxicity for transcription factor–targeted therapies. In this study, we exploit context-dependent differences in RNA polymerase II processivity as an approach t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4559f9c6213c0d59a323d14e5f5e7acc
https://doi.org/10.1158/1535-7163.c.6542218
https://doi.org/10.1158/1535-7163.c.6542218