Výsledky vyhledávání - "Susan M Green"

Safety and efficacy of opicinumab in patients with relapsing multiple sclerosis (SYNERGY)

Autor: Diego Cadavid, Michelle Mellion, Raymond Hupperts, Keith R Edwards, Peter A Calabresi, Jelena Drulović, Gavin Giovannoni, Hans-Peter Hartung, Douglas L Arnold, Elizabeth Fisher, Richard Rudick, Sha Mi, Yi Chai, Jie Li, Yiwei Zhang, Wenting Cheng, Lei Xu, Bing Zhu, Susan M Green, Ih Chang, Aaron Deykin, Sarah I Sheikh, Eduardo Agüera Morales, Abdullatif Al Khedr, Radek Ampapa, Rafael Arroyo, Martin Belkin, Robert Bonek, Alexey Boyko, Ruggero Capra, Diego Centonze, Pierre Clavelou, Marc Debouverie, Jelena Drulovic, Keith Edwards, Nikos Evangelou, Evgeniy Evdoshenko, Oscar Fernández, Victoria Fernández Sánchez, Mark Freedman, Steven Freedman, Waldemar Fryze, Antonio Garcia-Merino, Mira Gavric-Kezic, Angel Ghezzi, Olivier Gout, Luigi Grimaldi, Barry Hendin, Hanka Hertmanowska, Rogier Hintzen, Pavel Hradilek, Jan Ilkowski, Evelina Ivashinenkova, Guillermo Izquierdo, Francois Jacques, Gabor Jakab, Farit Khabirov, Gabriela Klodowska-Duda, Samuel Komoly, Smiljana Kostic, Ivana Kovarova, Marcelo Kremenchuzky, Christopher Laganke, Yves LaPierre, Maciej Maciejowski, Francois Grand Maison, Girolama Alessandra Marfia, Sergio Martínez Yélamos, Eva Meluzinova, Xavier Montalban, Ronald Murray, Robert Naismith, Scott Newsome, Viet Nguyen, Delia Oreja, Gabriel Pardo, Elena Pasechnik, Francesco Patti, Andrzej Potemkowski, Semen Prokopenko, Peiqing Qian, Alfredo Rodríguez-Antigüedad, Howard Rossman, Csilla Rozsa, Fernando Sánchez López, Krzysztof Selmaj, Eli Silber, Adam Stepien, Anna Stepniewska, Maciej Swiat, Gordana Toncev, Ayman Tourbah, Tatyana Trushnikova, Antonio Uccelli, Marta Vachova, Martin Valis, Laszlo Vecsei, Sandrine Wiertlewski, Mauro Zaffaroni, Tomasz Zielinski

Publikováno v: Lancet Neurology, 18(9), 845-856. Elsevier Science

Summary Background Opicinumab is a human monoclonal antibody against LINGO-1, an inhibitor of oligodendrocyte differentiation and axonal regeneration. Previous findings suggested that opicinumab treatment might enhance remyelination in patients with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07aa5a507f0c6b885918964f0fe4abe5
https://doi.org/10.1016/s1474-4422(19)30137-1

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Kinetic Evidence for Folding and Unfolding Intermediates in Staphylococcal Nuclease

Autor: William F. Walkenhorst, Heinrich Roder, Susan M. Green

Publikováno v: ResearcherID

The complex kinetic behavior commonly observed in protein folding studies suggests that a heterogeneous population of molecules exists in solution and that a number of discrete steps are involved in the conversion of unfolded molecules to the fully n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d095416ae22fadc13eeb31f8ffadf352
https://doi.org/10.1021/bi9700476

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One-step evolution of a dimer from a monomeric protein

Autor: Apostolos G. Gittis, Alan K. Meeker, Eaton E. Lattman, Susan M. Green

Publikováno v: Nature Structural & Molecular Biology. 2:746-751

Deletion of six amino acids in a surface loop transforms staphylococcal nuclease from a monomeric protein into a very stable dimer (Kd < 1 x 10(-8)M). A 2 A X-ray crystal structure of the dimer (R = 0.176) shows that the carboxy-terminal alpha-helix

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3370e21d67047065703ff882314c074f
https://doi.org/10.1038/nsb0995-746

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Patterns of nonadditivity between pairs of stability mutations in staphylococcal nuclease

Autor: David Shortle, Susan M. Green

Publikováno v: Biochemistry. 32:10131-10139

To identify interactions between amino acid positions in staphylococcal nuclease that affect its stability, a collection of 71 double-mutant forms was constructed from 22 previously characterized single mutants. These single mutations were assigned t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5b1ae8ff270777a896087220e931846
https://doi.org/10.1021/bi00089a032

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Structural basis for Chk1 inhibition by UCN-01

Autor: Kyung O. Johanson, Stephen T. Davis, Baoguang Zhao, Michael J. Bower, Bin-Bing S. Zhou, Nestor O. Concha, Huizhen Zhao, Patrick McDevitt, Susan M. Green

Publikováno v: The Journal of biological chemistry. 277(48)

Chk1 is a serine-threonine kinase that plays an important role in the DNA damage response, including G(2)/M cell cycle control. UCN-01 (7-hydroxystaurosporine), currently in clinical trials, has recently been shown to be a potent Chk1 inhibitor that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5630824b2e0d4d6c38948fa0d245827
https://pubmed.ncbi.nlm.nih.gov/12244092

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