Zobrazeno 1 - 10
of 284
pro vyhledávání: '"Susan M, Kaech"'
Autor:
Dijana Djureinovic, Sarah A. Weiss, Irina Krykbaeva, Rihao Qu, Ioannis Vathiotis, Myrto Moutafi, Lin Zhang, Ana L. Perdigoto, Wei Wei, Gail Anderson, William Damsky, Michael Hurwitz, Barbara Johnson, David Schoenfeld, Amit Mahajan, Frank Hsu, Kathryn Miller-Jensen, Yuval Kluger, Mario Sznol, Susan M. Kaech, Marcus Bosenberg, Lucia B. Jilaveanu, Harriet M. Kluger
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-15 (2023)
Abstract Background Stimulating inflammatory tumor associated macrophages can overcome resistance to PD-(L)1 blockade. We previously conducted a phase I trial of cabiralizumab (anti-CSF1R), sotigalimab (CD40-agonist) and nivolumab. Our current purpos
Externí odkaz:
https://doaj.org/article/4fa1a648e79343f59ea5d04accc2e62b
Autor:
Vikas B. Gubbala, Nidhi Jytosana, Vincent Q. Trinh, H. Carlo Maurer, Razia F. Naeem, Nikki K. Lytle, Zhibo Ma, Steven Zhao, Wei Lin, Haiyong Han, Yu Shi, Tony Hunter, Pankaj K. Singh, Kenneth P. Olive, Marcus C.B. Tan, Susan M. Kaech, Geoffrey M. Wahl, Kathleen E. DelGiorno
Publikováno v:
Gastro Hep Advances, Vol 1, Iss 4, Pp 682-697 (2022)
Background and Aims: Eicosanoids, oxidized fatty acids that serve as cell-signaling molecules, have been broadly implicated in tumorigenesis. Here, we aimed to identify eicosanoids associated with pancreatic tumorigenesis and the cell types responsib
Externí odkaz:
https://doaj.org/article/feecc0f1541240d993d5e3ead6ccabdb
Autor:
Karthik Chandiran, Jenny E Suarez-Ramirez, Yinghong Hu, Evan R Jellison, Zeynep Ugur, Jun Siong Low, Bryan McDonald, Susan M Kaech, Linda S Cauley
Publikováno v:
eLife, Vol 11 (2022)
Transforming growth factor β (TGFβ) is an important differentiation factor for cytotoxic T lymphocytes (CTLs) and alters the expression levels of several of homing receptors during infection. SMAD4 is part of the canonical signaling network used by
Externí odkaz:
https://doaj.org/article/3e1aa3771a354027943ff186a8c20248
Autor:
Anuradha Ganesan, Xun Wang, Yanhong Deng, Kurt A Schalper, Ryan C Maves, Brian Agan, Brinda Emu, Jason Okulicz, Omkar Chaudhary, Diane Trotta, Kaicheng Wang, Xiuping Chu, Chip Bradley, Karl Kronmann, Christina M Schofield, Jason M Blaylock, Susan M Kaech
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 4 (2022)
Externí odkaz:
https://doaj.org/article/790bc6ab6c864d529c2c0024a45ac28f
Autor:
Camila Robles-Oteiza, Deborah Ayeni, Stellar Levy, Robert J. Homer, Susan M. Kaech, Katerina Politi
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 11 (2021)
Conditional ablation of defined cell populations in vivo can be achieved using genetically engineered mice in which the human diphtheria toxin (DT) receptor (DTR) is placed under control of a murine tissue-specific promotor, such that delivery of DT
Externí odkaz:
https://doaj.org/article/d4f0aefa005e4a42a25399005ca41bcb
Autor:
Yuan Qian, Gabriel Arellano, Igal Ifergan, Jean Lin, Caroline Snowden, Taehyeung Kim, Jane Joy Thomas, Calvin Law, Tianxia Guan, Roumen D. Balabanov, Susan M. Kaech, Stephen D. Miller, Jaehyuk Choi
Publikováno v:
Cell Reports, Vol 36, Iss 8, Pp 109602- (2021)
Summary: Inappropriate CD4+ T helper (Th) differentiation can compromise host immunity or promote autoimmune disease. To identify disease-relevant regulators of T cell fate, we examined mutations that modify risk for multiple sclerosis (MS), a canoni
Externí odkaz:
https://doaj.org/article/c185f981875a4fcabe178219eb11b71c
Autor:
Lara M. Myers, Michal Caspi Tal, Laughing Bear Torrez Dulgeroff, Aaron B. Carmody, Ronald J. Messer, Gunsagar Gulati, Ying Ying Yiu, Matthew M. Staron, Cesar Lopez Angel, Rahul Sinha, Maxim Markovic, Edward A. Pham, Benjamin Fram, Aijaz Ahmed, Aaron M. Newman, Jeffrey S. Glenn, Mark M. Davis, Susan M. Kaech, Irving L. Weissman, Kim J. Hasenkrug
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
SIRPa is most commonly known as a phagocytosis inhibitory receptor expressed by myeloid cells. Here the authors show SIRPa is expressed on a subset of CD8+ T cells with higher proliferative and effector activity during the chronic phase of the immune
Externí odkaz:
https://doaj.org/article/1fe7158a38ec4c6c9bd116baa3bb1dee
Publikováno v:
Cold Spring Harbor perspectives in biology. 13(8)
Immunological memory is a hallmark of adaptive immunity that confers long-lasting protection from reinfections. Memory CD8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::48d6602c0e4177a322d9c7269731cc1a
https://pubmed.ncbi.nlm.nih.gov/34001529
https://pubmed.ncbi.nlm.nih.gov/34001529
Autor:
Alexandra Kuhlmann-Hogan, Thekla Cordes, Ziyan Xu, Kacie A. Traina, Camila Robles-Oteíza, Deborah Ayeni, Elizabeth M. Kwong, Stellar R. Levy, Mathew Nobari, George Z. Cheng, Reuben Shaw, Sandra L. Leibel, Christian M. Metallo, Katerina Politi, Susan M. Kaech
Publikováno v:
bioRxiv
The limited efficacy of currently approved immunotherapies in EGFR-mutant lung adenocarcinoma (LUAD) underscores the need to better understand mechanisms governing local immunosuppression. Elevated surfactant and GM-CSF secretion from the transformed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06821c4e35a9bc53d4335381263abcc3
https://doi.org/10.1101/2023.04.15.536974
https://doi.org/10.1101/2023.04.15.536974
Autor:
Katerina Politi, Roy S. Herbst, Kurt Schalper, Susan M. Kaech, David L. Rimm, Paula Kavathas, Soldano Ferrone, Richard Lifton, Luis M. Montuenga, Jackeline Agorreta, Ignacio Melero, Miguel F. Sanmamed, Anne Chiang, Sarah B. Goldberg, Joseph Schlessinger, Victor Y. Du, Mary Ann Melnick, Guoping Cai, Weilai Dong, Anna Wurtz, Ryan Sowell, Ila Datar, Anna Truini, Katherine Hastings, Jungmin Choi, Scott Gettinger
Table with Details of Patient Characteristics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7db4d6d12723636f1cc30f480647eaf
https://doi.org/10.1158/2159-8290.22532594
https://doi.org/10.1158/2159-8290.22532594