Zobrazeno 1 - 10
of 190
pro vyhledávání: '"Susan Lin"'
Autor:
Yun Zhang, Susan Lin, Jing Yao, Wantong Cai, Huaqiu Chen, Ailikemu Aierken, Zhe Wang, Weihong Song
Publikováno v:
Genes and Diseases, Vol 11, Iss 5, Pp 101148- (2024)
As a pathological hallmark of type 2 diabetes mellitus (T2DM), islet amyloid is formed by the aggregation of islet amyloid polypeptide (IAPP). Endoplasmic reticulum (ER) stress interacts with IAPP aggregates and has been implicated in the pathogenesi
Externí odkaz:
https://doaj.org/article/8527f4bb162941a4974f9283ef5f1521
Autor:
Sujani Ariyadasa, Sophie van Hamelsveld, William Taylor, Susan Lin, Panan Sitthirit, Liping Pang, Craig Billington, Louise Weaver
Publikováno v:
Pathogens, Vol 13, Iss 8, p 665 (2024)
Free-living amoebae (FLA) are common in both natural and engineered freshwater ecosystems. They play important roles in biofilm control and contaminant removal through the predation of bacteria and other taxa. Bacterial predation by FLA is also thoug
Externí odkaz:
https://doaj.org/article/5dd830ff0b2b4cb8ae9bb5f83756de61
Gain-of-function MARK4 variant associates with pediatric neurodevelopmental disorder and dysmorphism
Autor:
Simran Samra, Mehul Sharma, Maryam Vaseghi-Shanjani, Kate L. Del Bel, Loryn Byres, Susan Lin, Joshua Dalmann, Areesha Salman, Jill Mwenifumbo, Bhavi P. Modi, Catherine M. Biggs, Cyrus Boelman, Lorne A. Clarke, Anna Lehman, Stuart E. Turvey
Publikováno v:
HGG Advances, Vol 5, Iss 1, Pp 100259- (2024)
Summary: Microtubule affinity-regulating kinase 4 (MARK4) is a serine/threonine kinase that plays a key role in tau phosphorylation and regulation of the mammalian target of rapamycin (mTOR) pathway. Abnormal tau phosphorylation and dysregulation of
Externí odkaz:
https://doaj.org/article/bf3e9fa10478485a97952f4e524c5f92
Autor:
Cordula S. Hege, Amy Stimpson, Joseph Sefton, James Summers, Helena Henke, Adam A. Dundas, Tony Phan, Robert Kinsey, Jeffrey A. Guderian, Sandra J. Sivananthan, Raodoh Mohamath, William R. Lykins, Gabi Ramer-Denisoff, Susan Lin, Christopher B. Fox, Derek J. Irvine
Publikováno v:
Polymers, Vol 15, Iss 18, p 3831 (2023)
This report details the first systematic screening of free-radical-produced methacrylate oligomer reaction mixtures as alternative vaccine adjuvant components to replace the current benchmark compound squalene, which is unsustainably sourced from sha
Externí odkaz:
https://doaj.org/article/fb5a20a0cb5c4f9aa9eb5c1037d478c9
Autor:
Bhavi P. Modi, Kate L. Del Bel, Susan Lin, Mehul Sharma, Phillip A. Richmond, Clara D. M. van Karnebeek, Edmond S. Chan, Vishal Avinashi, Wingfield E. Rehmus, Catherine M. Biggs, Wyeth W. Wasserman, Stuart E. Turvey
Publikováno v:
Allergy, Asthma & Clinical Immunology, Vol 17, Iss 1, Pp 1-6 (2021)
Abstract X-linked hypohidrotic ectodermal dysplasia (XLHED) is the most common form of ectodermal dysplasia. Clinical and genetic heterogeneity between different ectodermal dysplasia types and evidence of incomplete penetrance and variable expressivi
Externí odkaz:
https://doaj.org/article/dbee9e32ab0f4bbda7b133fd0e89a2a9
A spatially resolved brain region- and cell type-specific isoform atlas of the postnatal mouse brain
Autor:
Anoushka Joglekar, Andrey Prjibelski, Ahmed Mahfouz, Paul Collier, Susan Lin, Anna Katharina Schlusche, Jordan Marrocco, Stephen R. Williams, Bettina Haase, Ashley Hayes, Jennifer G. Chew, Neil I. Weisenfeld, Man Ying Wong, Alexander N. Stein, Simon A. Hardwick, Toby Hunt, Qi Wang, Christoph Dieterich, Zachary Bent, Olivier Fedrigo, Steven A. Sloan, Davide Risso, Erich D. Jarvis, Paul Flicek, Wenjie Luo, Geoffrey S. Pitt, Adam Frankish, August B. Smit, M. Elizabeth Ross, Hagen U. Tilgner
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Alternative RNA splicing varies across the brain. Its mapping at single cell resolution is unclear. Here, the authors provide a spatial and single-cell splicing atlas reporting brain region- and cell type-specific expression of different isoforms in
Externí odkaz:
https://doaj.org/article/b27a2afb47544e009093959c837b41e3
Autor:
Mayuresh M. Abhyankar, Mark T. Orr, Robert Kinsey, Sandra Sivananthan, Andrew J. Nafziger, David N. Oakland, Mary K. Young, Laura Farr, Md Jashim Uddin, Jhansi L. Leslie, Stacey L. Burgess, Hong Liang, Ines De Lima, Elise Larson, Jeffrey A. Guderian, Susan Lin, Aaron Kahn, Prakash Ghosh, Sierra Reed, Mark A. Tomai, Karl Pedersen, William A. Petri, Christopher B. Fox
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Amebiasis is a neglected tropical disease caused by Entamoeba histolytica. Although the disease burden varies geographically, amebiasis is estimated to account for some 55,000 deaths and millions of infections globally per year. Children and traveler
Externí odkaz:
https://doaj.org/article/27f8546d80654205a8c42df32dd87af3
Autor:
Xiaohui Lv, Si-Qiang Ren, Xin-Jun Zhang, Zhongfu Shen, Tanay Ghosh, Anjin Xianyu, Peng Gao, Zhizhong Li, Susan Lin, Yang Yu, Qiangqiang Zhang, Matthias Groszer, Song-Hai Shi
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
The T-box protein TBR2 is involved in cortical neurogenesis expansion during neurodevelopment and is preferentially enriched in intermediate progenitors. The authors show that TBR2 coordinates neurogenesis expansion and precise microcircuit assembly
Externí odkaz:
https://doaj.org/article/f4a5d9c9f50f44238de1e4075548dbfd
Autor:
Leif Carlsson, Jonathan C. Clarke, Christopher Yen, Francine Gregoire, Tamsin Albery, Martin Billger, Ann-Charlotte Egnell, Li-Ming Gan, Karin Jennbacken, Edvin Johansson, Gunilla Linhardt, Sofia Martinsson, Muhammad Waqas Sadiq, Nevin Witman, Qing-Dong Wang, Chien-Hsi Chen, Yu-Ping Wang, Susan Lin, Barry Ticho, Patrick C.H. Hsieh, Kenneth R. Chien, Regina Fritsche-Danielson
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 9, Iss , Pp 330-346 (2018)
mRNA can direct dose-dependent protein expression in cardiac muscle without genome integration, but to date has not been shown to improve cardiac function in a safe, clinically applicable way. Herein, we report that a purified and optimized mRNA in a
Externí odkaz:
https://doaj.org/article/323a8ccca84c43bd8436f92356b5feeb
Autor:
Yongsung Hwang, Samuel Suk, Susan Lin, Matthew Tierney, Bin Du, Timothy Seo, Aaron Mitchell, Alessandra Sacco, Shyni Varghese
Publikováno v:
PLoS ONE, Vol 8, Iss 9 (2013)
[This corrects the article on p. e72023 in vol. 8.].
Externí odkaz:
https://doaj.org/article/f71fd95b68b74854a53b099e1586f28e