Výsledky vyhledávání - "Susan Laffan"

Akademický článek

The benefits, limitations and opportunities of preclinical models for neonatal drug development

Autor: Sarah Campion, Amy Inselman, Belinda Hayes, Costanza Casiraghi, David Joseph, Fabrizio Facchinetti, Fabrizio Salomone, Georg Schmitt, Julia Hui, Karen Davis-Bruno, Karen Van Malderen, LaRonda Morford, Luc De Schaepdrijver, Lutz Wiesner, Stephanie Kourula, Suna Seo, Susan Laffan, Vijay Urmaliya, Connie Chen

Publikováno v: Disease Models & Mechanisms, Vol 15, Iss 4 (2022)

Increased research to improve preclinical models to inform the development of therapeutics for neonatal diseases is an area of great need. This article reviews five common neonatal diseases – bronchopulmonary dysplasia, retinopathy of prematurity,

Externí odkaz: https://doaj.org/article/2b780bb945cf480c8f579328eb912ef4

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The inhibin B response to a motilin receptor agonist in male rats

Autor: Mary K, Ziejewski, Justin D, Vidal, Dinesh, Stanislaus, April, Apostoli, Probash, Chowdhury, Susan, Laffan

Publikováno v: Birth defects research. Part B, Developmental and reproductive toxicology. 98(1)

In a repeat oral dose toxicity study, all of 16 male rats given 100 mg/kg/day GSK1322888 sustained testicular injury after 4 weeks of treatment; the findings were not reversible after 12 weeks off-dose. The current study was conducted to further char

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0ad31c95215e57688f4b723902e47a8e
https://pubmed.ncbi.nlm.nih.gov/23348917

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Summary of the HESI consortium studies exploring circulating inhibin B as a potential biomarker of testis damage in the rat

Autor: Robert, Chapin, Gerhard, Weinbauer, Michael S, Thibodeau, Manisha, Sonee, Louise Parks, Saldutti, William J, Reagan, David, Potter, Jeffrey S, Moffit, Susan, Laffan, James H, Kim, Richard A, Goldstein, Zoltan, Erdos, Brian P, Enright, Michelle, Coulson, William J, Breslin

Publikováno v: Birth defects research. Part B, Developmental and reproductive toxicology. 98(1)

The Developmental and Reproductive Toxicity Technical Committee of the Health and Environmental Sciences Institute hosted a working consortium of companies to evaluate a new commercially available analytic assay for Inhibin B in rat serum or plasma.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::57fd83b0238d2ad2645335d583d97c74
https://pubmed.ncbi.nlm.nih.gov/23364877

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