Výsledky vyhledávání - "Susan L. Wang"

Preparation of a Bispecific F(ab')2 Targeted to the Human IL-2 Receptor

Autor: Susan L. Wang, J. Yun Tso, John Hakimi, Wayne Levin

Publikováno v: Journal of Hematotherapy. 4:389-394

The heterodimer-forming leucine zippers Fos and Jun can efficiently mediate the formation of bispecific F(ab')2 when they are fused separately to two different Fab' fragments. This recombinant method can be used in conjunction with the humanization p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45c95d9da2466193f7db4d6dd7202326
https://doi.org/10.1089/scd.1.1995.4.389

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Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanisms

Autor: Jun R. Huh, R. M. Renny Feldman, Bruce A. Hay, Israel Muro, H.-Arno J. Müller, Hong Yu, Lijuan Wang, Soon Ji Yoo, Rollie J. Clem, Susan L. Wang

Publikováno v: Nature cell biology. 4(6)

Inhibitor of apoptosis (IAP) proteins suppress apoptosis and inhibit caspases. Several IAPs also function as ubiquitin-protein ligases. Regulators of IAP auto-ubiquitination, and thus IAP levels, have yet to be identified. Here we show that Head invo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2349697387066606311b54875db67e64
https://pubmed.ncbi.nlm.nih.gov/12021767

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The Drosophila caspase DRONC is a glutamate/aspartate protease whose activity is regulated by DIAP1, HID and GRIM

Autor: Stephanie Y. Vernooy, Soon Ji Yoo, Bruce A. Hay, Susan L. Wang, Erin P. Peterson, Christine J. Hawkins

Publikováno v: Journal of Biological Chemistry.

The caspase family of cysteine proteases plays important roles in bringing about apoptotic cell death. All caspases studied to date cleave substrates COOH-terminal to an aspartate. Here we show that the Drosophila caspase DRONC cleaves COOH-terminal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8da21fb576dcf91a34e12f86c1dd964c
https://doi.org/10.1074/jbc.m000869200

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Monitoring Activity of Caspases and Their Regulators in Yeast Saccharomyces cerevisiae

Autor: Susan L. Wang, Bruce A. Hay, Christine J. Hawkins

Publikováno v: ResearcherID

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b205c213437b9db03d0102432724b6
https://doi.org/10.1016/s0076-6879(00)22016-8

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A cloning method to identify caspases and their regulators in yeast: Identification of Drosophila IAP1 as an inhibitor of the Drosophila caspase DCP-1

Autor: Susan L. Wang, Christine J. Hawkins, Bruce A. Hay

Publikováno v: ResearcherID

Site-specific proteases play critical roles in regulating many cellular processes. To identify novel site-specific proteases, their regulators, and substrates, we have designed a general reporter system in Saccharomyces cerevisiae in which a transcri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d338565f2d137d8ee35f1ecdba17fcc5
https://resolver.caltech.edu/CaltechAUTHORS:20141125-135327646

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The Drosophila Caspase Inhibitor DIAP1 Is Essential for Cell Survival and Is Negatively Regulated by HID

Autor: H.-Arno J. Müller, Christine J. Hawkins, Susan L. Wang, Soon Ji Yoo, Bruce A. Hay

Publikováno v: ResearcherID

>Drosophila Reaper (RPR), Head Involution Defective (HID), and GRIM induce caspase-dependent cell death and physically interact with the cell death inhibitor DIAP1. Here we show that HID blocks DIAP1's ability to inhibit caspase activity and provide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19731dac2603ec98aa5c4b3831f07047

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