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pro vyhledávání: '"Susan L. Merrihew"'
Autor:
Cristin M. Galardi, John T. Moore, Stephen M. Hyatt, Richard G. Buckholz, Timothy M. Willson, William J. Zuercher, Susan L. Merrihew, Nino Campobasso, Paul Reid, Eugene L. Stewart, Jon L. Collins, Thomas B. Stanley, Paul Kenneth Spearing, Robert T. Gampe, Jeffrey Alan Oplinger
Publikováno v:
Journal of medicinal chemistry. 53(8)
Tertiary sulfonamides were identified in a HTS as dual liver X receptor (LXR, NR1H2, and NR1H3) ligands, and the binding affinity of the series was increased through iterative analogue synthesis. A ligand-bound cocrystal structure was determined whic