Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Susan L. Kalis"'
Autor:
Linda B. Baughn, Susan L. Kalis, Thomas MacCarthy, Lirong Wei, Manxia Fan, Aviv Bergman, Matthew D. Scharff
Publikováno v:
mBio, Vol 2, Iss 5 (2011)
ABSTRACT Activation-induced cytidine deaminase (AID) mediates the somatic hypermutation (SHM) of immunoglobulin (Ig) variable (V) regions that is required for the generation of antibody diversity and for the affinity maturation of the antibody respon
Externí odkaz:
https://doaj.org/article/5cc1e766bcb347778226b18dc0279ba3
Autor:
Katherine L. Knight, Laurel Druschitz, Pamela L. Witte, Basile T. Siewe, Simon J. Conway, Phong T. Le, Susan L. Kalis, Sangdun Choi
Publikováno v:
Blood. 117:3770-3779
B lymphopoiesis arrests in rabbits by 4 months of age. To identify molecules that contribute to this arrest, cDNA–representational difference analysis on BM stromal cells from young and adult rabbits showed that expression of Postn that encodes for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57610aed968cc2dccf7637801d80775c
https://doi.org/10.1182/blood-2010-08-301119
https://doi.org/10.1182/blood-2010-08-301119
Autor:
Phuong Pham, Matthew D. Scharff, Myron F. Goodman, Thomas MacCarthy, Aviv Bergman, Sergio Roa, Susan L. Kalis
Publikováno v:
Proceedings of the National Academy of Sciences. 106:8629-8634
The somatic hypermutation of Ig variable regions requires the activity of activation-induced cytidine deaminase (AID) which has previously been shown to preferentially deaminate WRC (W = A/T, R = A/G) motif hot spots in in vivo and in vitro assays. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2da2a5b2b60ef907011a67fbb12fc42a
https://doi.org/10.1073/pnas.0903803106
https://doi.org/10.1073/pnas.0903803106
Autor:
Maria D. Iglesias-Ussel, Matthew D. Scharff, Fei Li Kuang, Sergio Roa, Susan L. Kalis, Jonathan U. Peled, Myron F. Goodman
Publikováno v:
Annual Review of Immunology. 26:481-511
Affinity maturation of the humoral response is mediated by somatic hypermutation of the immunoglobulin (Ig) genes and selection of higher-affinity B cell clones. Activation-induced cytidine deaminase (AID) is the first of a complex series of proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c716e55af0b653ca8366cf89daeb03b6
https://doi.org/10.1146/annurev.immunol.26.021607.090236
https://doi.org/10.1146/annurev.immunol.26.021607.090236
Autor:
Katherine L. Knight, Pi Chen Yam, Susan L. Kalis, Periannan Sethupathi, Paul J. Jasper, Ki Jong Rhee, Shi Kang Zhai
Publikováno v:
European Journal of Immunology. 37:2290-2299
We developed IgH-transgenic rabbits carrying a productive VDJ-Cmu Tg and found the rabbits were B cell-deficient, with a 50-100% reduction in serum IgM and IgG levels. The bone marrow of newborn Tg rabbits contained severely reduced levels of preB ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29ca2e2fc65901c74a1e18d95658e8cc
https://doi.org/10.1002/eji.200737191
https://doi.org/10.1002/eji.200737191
Publikováno v:
International Immunology. 19:801-811
B lymphopoiesis in rabbits is robust early in ontogeny, but is arrested by 16 weeks of age at which time no proB or preB cells are found in bone marrow (BM). To determine if BM cells from adults retain B lymphopoietic potential, we transferred BM fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d7ea6e71d0f94e93beda99d97533a34
https://doi.org/10.1093/intimm/dxm048
https://doi.org/10.1093/intimm/dxm048
Publikováno v:
The Journal of Immunology. 171:6372-6380
In mammals that use gut-associated lymphoid tissues for expansion and somatic diversification of the B cell repertoire, B lymphopoiesis occurs early in ontogeny and does not appear to continue throughout life. In these species, including sheep, rabbi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9035d6616d27e05c1c7df14ffa5ba0d3
https://doi.org/10.4049/jimmunol.171.12.6372
https://doi.org/10.4049/jimmunol.171.12.6372
Autor:
Manxia Fan, Linda B. Baughn, Aviv Bergman, Lirong Wei, Susan L. Kalis, Matthew D. Scharff, Thomas MacCarthy
Publikováno v:
mBio
mBio, Vol 2, Iss 5 (2011)
mBio, Vol 2, Iss 5 (2011)
Activation-induced cytidine deaminase (AID) mediates the somatic hypermutation (SHM) of immunoglobulin (Ig) variable (V) regions that is required for the generation of antibody diversity and for the affinity maturation of the antibody response agains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eb38ee5ac6945f323231652ae1053fd
https://doi.org/10.1128/mbio.00186-11
https://doi.org/10.1128/mbio.00186-11
Publikováno v:
Developmental and comparative immunology. 34(8)
IL-7 is required for B cell development in mouse and is a key regulator of T cell development and peripheral T cell homeostasis in mouse and human. Recently, we found that IL-7 is expressed in rabbit bone marrow and in vitro, is required for differen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6ef7c46f3612f260497c7060d821602
https://pubmed.ncbi.nlm.nih.gov/20304004
https://pubmed.ncbi.nlm.nih.gov/20304004