Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Susan L. Hockerman"'
Autor:
E. Jon Jacobsen, Matthew J. Saabye, Chun Wang, Jeffrey L. Hirsch, Sheri L. Bonar, Gabriel Mbalaviele, Shaun R. Selness, Hal M. Hoffman, Susan L. Hockerman, Yael Alippe, Joseph B. Monahan, William F. Hood, Stephen J. Mnich, Yousef Abu-Amer, Ariela Haimovich, Heidi R. Hope
Publikováno v:
The Journal of Experimental Medicine
A unique p38α MAPK–MK2 pathway inhibitor, CDD-450, is used to uncover the function of this protein complex in inflammasome priming signals. Importantly, CDD-450 is as efficacious as global p38α MAPK inhibitors in decreasing inflammation in diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::531a33bf2ac0ef32007b6033ed6f2f52
https://pubmed.ncbi.nlm.nih.gov/29686326
https://pubmed.ncbi.nlm.nih.gov/29686326
Autor:
Jeffery N. Carroll, Craig Swearingen, Decrescenzo Gary A, Rico Joseph G, Theresa R. Fletcher, Daniel P. Becker, Joseph J. McDonald, Susan L. Hockerman, Grace E. Munie, Stephen A. Kolodziej, Boehm Terri L, Debbie A. Mischke, Nathan W. Stehle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:3557-3560
A series of phenyl piperidine alpha-sulfone hydroxamate derivatives has been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13, are dual-sparing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b61c5bde65513f60ea0896cfb24e7ec
https://doi.org/10.1016/j.bmcl.2010.04.130
https://doi.org/10.1016/j.bmcl.2010.04.130
Autor:
Daniel P. Becker, Theresa R. Fletcher, Debbie A. Mischke, Joseph J. McDonald, Stephen A. Kolodziej, Nathan W. Stehle, Susan L. Hockerman, Grace E. Munie, Craig Swearingen, Decrescenzo Gary A
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:3561-3564
A series of N-aryl isonipecotamide alpha-sulfone hydroxamate derivatives has been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e95e2ec754d4d05a448abe4797fbdd4
https://doi.org/10.1016/j.bmcl.2010.04.111
https://doi.org/10.1016/j.bmcl.2010.04.111
Autor:
Scott Santford Woodard, Daniel L. Flynn, Rajesh V. Devraj, Joyce Z. Crich, John J. Parlow, Susan L. Hockerman, and Michael S. South
Publikováno v:
Journal of the American Chemical Society. 119:4874-4881
A new methodology for solution-phase chemical library synthesis and purification is described. This approach applies fundamental properties of complementary molecular reactivity and recognition (CMR/R) as the basis for a general purification strategy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::751932bfb78c1ebe333d60b829183a03
https://doi.org/10.1021/ja963462e
https://doi.org/10.1021/ja963462e
Autor:
Karl J. Mathis, Madeleine H. Li, Alan M. Easton, Clara I. Villamil, Barta Thomas E, Grace E. Munie, Daniel P. Becker, Jennifer M. Williams, James R. Kiefer, Louis J. Bedell, Rico Joseph G, Susan L. Hockerman
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(10)
Seeking compounds preferentially potent and selective for MMP-13, we reported in the preceding Letter on a series of hydroxamic acids with a flexible benzamide tail groups.(1a) Here, we replace the amide moiety with non-hydrolyzable heterocycles in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78ffe35bcbf17ed83e09ea89e7da6550
https://pubmed.ncbi.nlm.nih.gov/21507637
https://pubmed.ncbi.nlm.nih.gov/21507637
Autor:
John N. Freskos, Craig Swearingen, Getman Daniel P, Pramod P. Mehta, Grace E. Munie, Daniel P. Becker, Susan L. Hockerman, Madeleine Li, Decrescenzo Gary A
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:2723-2725
A series of α-alkyl-α-amino-β-sulphone hydroxamates was prepared and evaluated for potency versus MMP-2 and MMP-13, and for selectivity versus MMP-1. Low nanomolar potency was obtained with selectivity versus MMP-1 ranging from >10 to >1000. Selec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1532a87d600b0673f0ba421e0a7e689c
https://doi.org/10.1016/s0960-894x(01)00557-1
https://doi.org/10.1016/s0960-894x(01)00557-1
Autor:
Chris P. Carron, Madeleine H. Li, Daniel P. Becker, T. Sunyer, John N. Freskos, Louis J. Bedell, Boehm Terri L, Chris L. Funckes-Shippy, Decrescenzo Gary A, Clara I. Villamil, Joseph J. McDonald, Grace E. Munie, Jeffery N. Carroll, Pramod P. Mehta, Jun Yao, Brian R. Bond, Craig Swearingen, Jennifer M. Williams, Barta Thomas E, Marcia I. Heron, Dean Welsch, Karl J. Mathis, Carol Pearcy Howard, James R. Kiefer, Susan L. Hockerman, Alan M. Easton, Ying Yu
Publikováno v:
Journal of medicinal chemistry. 53(18)
α-Sulfone-α-piperidine and α-tetrahydropyranyl hydroxamates were explored that are potent inhibitors of MMP's-2, -9, and -13 that spare MMP-1, with oral efficacy in inhibiting tumor growth in mice and left-ventricular hypertrophy in rats and in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9685357a0ce79c92aebc66064d268699
https://pubmed.ncbi.nlm.nih.gov/20726512
https://pubmed.ncbi.nlm.nih.gov/20726512
Autor:
David B. Reitz, Xiangyang Chen, James Robert Blinn, Horng-Chih Huang, Kevin F. McGee, Shengtian Yang, Marvin J. Meyers, Jessica D. Dietz, Danny J. Garland, Joseph R. Rico, Graciela B. Arhancet, Joe T. Collins, Maria A. Payne, Matthew W. Mahoney, Susan L. Hockerman, Marcia I. Heron, Xiao Hu, Bruce L. Homer, Scott A. Long, Jay M. Wendling
Publikováno v:
Journal of medicinal chemistry. 53(16)
We have discovered a novel class of nonsteroidal pyrazoline antagonists of the mineralocorticoid receptor (MR) that show excellent potency and selectivity against other nuclear receptors. Early analogues were poorly soluble and had a propensity to in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f050d0c3dc870966f983df9d6dea1c
https://pubmed.ncbi.nlm.nih.gov/20672822
https://pubmed.ncbi.nlm.nih.gov/20672822
Autor:
Susan L. Hockerman, Pramod P. Mehta, John N. Freskos, Daniel P. Becker, Getman Daniel P, Craig Swearingen, Grace E. Munie, Decrescenzo Gary A, Madeleine Li
Publikováno v:
ChemInform. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fed804aa2855b42414bafce6ab387e4f
https://doi.org/10.1002/chin.200204200
https://doi.org/10.1002/chin.200204200
Autor:
Chris P. Carron, Craig Swearingen, Louis J. Bedell, John N. Freskos, Getman Daniel P, Clara I. Villamil, Grace E. Munie, Pramod P. Mehta, Boehm Terri L, Barta Thomas E, Madeleine H. Li, Daniel P. Becker, Susan L. Hockerman, Susan C. Howard, Heintz Robert M, Joseph J. McDonald, Chris L. Funckes-Shippy, Decrescenzo Gary A
Publikováno v:
Journal of medicinal chemistry. 48(21)
alpha-Piperidine-beta-sulfone hydroxamate derivatives were explored that are potent for matrix metalloproteinases (MMP)-2, -9, and -13 and are sparing of MMP-1. The investigation of the beta-sulfones subsequently led to the discovery of hitherto unkn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0539500154a05a00e3a097afebbcc7a1
https://pubmed.ncbi.nlm.nih.gov/16220987
https://pubmed.ncbi.nlm.nih.gov/16220987