Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Susan L. Dyos"'
Autor:
Susan L. Dyos, Emma Hiley, Angela A. Dunne, Mary A. Morse, Fiona Flett, Martin Rüdiger, Edward Hollingsworth, Namir J. Hassan, Martin Hibbs, Jonathan P. Hutchinson, David G. Tew, Amanda Emmons, David J. Powell, Jeremy D. A. Kitson, Sheraz Gul
Publikováno v:
Biochemical Journal. 419:65-73
Identification of small-molecule inhibitors by high-throughput screening necessitates the development of robust, reproducible and cost-effective assays. The assay approach adopted may utilize isolated proteins or whole cells containing the target of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed4f87f33b575ebe8700adca9d63259f
https://doi.org/10.1042/bj20081646
https://doi.org/10.1042/bj20081646
Autor:
Simon J. Dowell, Martina Marzioch, Malcolm S. Whiteway, Jeffrey J. Clare, Julia H. White, Andrew J. Brown, Marie-Ange Watson, Diane J. Cousens, Chris Paddon, Susan L. Dyos, M A Romanos, Chris Plumpton
Publikováno v:
Yeast. 16:11-22
The expression of mammalian G protein coupled receptors (GPCRs) in S. cerevisiae provides a powerful assay system for functional analysis, ligand identification and pharmaceutical screening. However, relatively few receptors have been coupled to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::775c4cc88a8131b9e1381ffa6b86f520
https://doi.org/10.1002/(sici)1097-0061(20000115)16:1<11::aid-yea502>3.0.co
https://doi.org/10.1002/(sici)1097-0061(20000115)16:1<11::aid-yea502>3.0.co
Publikováno v:
Genetics. 150:1407-1417
The mating pathway of Saccharomyces cerevisiae is widely used as a model system for G protein-coupled receptor-mediated signal transduction. Following receptor activation by the binding of mating pheromones, G protein βγ subunits transmit the signa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b129aa544f3a2071ce136a1a50fdfb0
https://doi.org/10.1093/genetics/150.4.1407
https://doi.org/10.1093/genetics/150.4.1407
Publikováno v:
The Journal of Cell Biology
Monoclonal antibodies against the 110-kD component of the yeast spindle pole body (SPB) were used to clone the corresponding gene SPC110. SPC110 is identical to NUF1 (Mirzayan, C., C. S. Copeland, and M. Synder. 1992. J. Cell Biol. 116:1319-1332). SP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf60a5267fc5d0e0c59dacc9b79772bc
http://europepmc.org/articles/PMC2119877
http://europepmc.org/articles/PMC2119877
Autor:
Barbara G. Avitabile, Paul Bamborough, John A. Christopher, Michael J. Wilson, Aurelie C. Champigny, Geoffrey W. Mellor, Ken Grace, Jeremy D. A. Kitson, Nicholas Probst, Clive A. Smith, Champa Patel, Susan L. Dyos, William L. Rumsey, Jeffrey K. Kerns, James V. Morey, Mary A. Morse, Carolyn F. O’Malley, Geoffrey J. Cutler
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(14)
A potent and selective series of 2-amino-3,5-diarylbenzamide inhibitors of IKK-α and IKK-β is described. The most potent compounds are 8h , 8r and 8v , with IKK-β inhibitory potencies of pIC 50 7.0, 6.8 and 6.8, respectively. The series has excell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::662d566d583ef34be934dd8aef6c31b8
https://pubmed.ncbi.nlm.nih.gov/17502144
https://pubmed.ncbi.nlm.nih.gov/17502144
Autor:
Lorna A. Casselton, Natalie S. Olesnicky, Andrew J. Brown, Simon J. Dowell, Susan L. Dyos, Yoichi Honda
Publikováno v:
Europe PubMed Central
A successful mating in the mushroom Coprinus cinereus brings together a compatible complement of pheromones and G-protein-coupled receptors encoded by multiallelic genes at the B mating-type locus. Rare B gene mutations lead to constitutive activatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c40e24d87e9bd1eacc58b66bcf4994
http://europepmc.org/abstract/med/11063682
http://europepmc.org/abstract/med/11063682
