Zobrazeno 1 - 10
of 344
pro vyhledávání: '"Susan L. Cohn"'
Autor:
Monica Pomaville, Mohansrinivas Chennakesavalu, Pingluan Wang, Zhiwei Jiang, Hui-Lung Sun, Peizhe Ren, Ryan Borchert, Varsha Gupta, Chang Ye, Ruiqi Ge, Zhongyu Zhu, Mallory Brodnik, Yuhao Zhong, Kelley Moore, Helen Salwen, Rani E. George, Malgorzata Krajewska, Alexandre Chlenski, Mark A. Applebaum, Chuan He, Susan L. Cohn
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114165- (2024)
Summary: The N6-methyladenosine (m6A) RNA modification is an important regulator of gene expression. m6A is deposited by a methyltransferase complex that includes methyltransferase-like 3 (METTL3) and methyltransferase-like 14 (METTL14). High levels
Externí odkaz:
https://doaj.org/article/b70135c60c274c8db78ac7b2b49f0621
Autor:
Mohansrinivas Chennakesavalu, Caileigh Pudela, Mark A. Applebaum, Sang Mee Lee, Yan Che, Arlene Naranjo, Julie R. Park, Samuel L. Volchenboum, Tara O. Henderson, Susan L. Cohn, Ami V. Desai
Publikováno v:
EJC Paediatric Oncology, Vol 2, Iss , Pp 100022- (2023)
Background: Racial/ethnic survival disparities in neuroblastoma were first reported more than a decade ago. We sought to investigate if these disparities have persisted with current era therapy. Methods: Two patient cohorts were identified in the Int
Externí odkaz:
https://doaj.org/article/0884887593ac4022bd8dab8a00e8d3e1
Autor:
Anastasia E. Hains, Sakshi Uppal, John Z. Cao, Helen R. Salwen, Mark A. Applebaum, Susan L. Cohn, Lucy A. Godley
Publikováno v:
Epigenetics, Vol 17, Iss 13, Pp 2056-2074 (2022)
Ten-Eleven-Translocation 5-methylcytosine dioxygenases 1–3 (TET1-3) convert 5-methylcytosine to 5-hydroxymethylcytosine (5-hmC), using oxygen as a co-substrate. Contrary to expectations, hypoxia induces 5-hmC gains in MYCN-amplified neuroblastoma (
Externí odkaz:
https://doaj.org/article/46684909df9349bab0c0b5b0bbd13c9a
Autor:
Christopher J. Mariani, Aparna Vasanthakumar, Jozef Madzo, Ali Yesilkanal, Tushar Bhagat, Yiting Yu, Sanchari Bhattacharyya, Roland H. Wenger, Susan L. Cohn, Jayasri Nanduri, Amit Verma, Nanduri R. Prabhakar, Lucy A. Godley
Publikováno v:
Cell Reports, Vol 7, Iss 5, Pp 1343-1352 (2014)
The ten-eleven-translocation 5-methylcytosine dioxygenase (TET) family of enzymes catalyzes the conversion of 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC), a modified cytosine base that facilitates gene expression. Cells respond to hypo
Externí odkaz:
https://doaj.org/article/93fdb6758d1c4cb3b01498f38adee887
Autor:
Prasad Mathew, Marcus B. Valentine, Laura C. Bowman, Susan T. Rowe, Michael B. Nash, Virginia A. Valentine, Susan L. Cohn, Robert P. Castleberry, Garrett M. Brodeur, A. Thomas Look
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 3, Iss 2, Pp 105-109 (2001)
To assess the utility of fluorescence in situ hybridization (FISH) for analysis of MYCN gene amplification in neuroblastoma, we compared this assay with Southern blot analysis using tumor specimens collected from 232 patients with presenting characte
Externí odkaz:
https://doaj.org/article/0c695a17358b42c488749c9c0cc168d2
Autor:
Xiao-Tang Kong, Virginia A. Valentine, Susan T. Rowe, Marcus B. Valentine, Susan T. Ragsdale, Bart G. Jones, Deborah A. Wilkinson, Garrett M. Brodeur, Susan L. Cohn, A. Thomas Look
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 1, Iss 1, Pp 80-89 (1999)
We examined 18 neuroblastoma cell lines and 32 primary single-copy MYCN tumor specimens to determine whether mutations of p73, a novel p53-related gene located in chromosome band 1p36.33, contribute to the genesis or progression of childhood neurobla
Externí odkaz:
https://doaj.org/article/c840ba0c1b1247daa4e6f094e834c183
Autor:
Ami V. Desai, Andrew L. Gilman, Mehmet Fevzi Ozkaynak, Arlene Naranjo, Wendy B. London, Sheena C. Tenney, Mitchell Diccianni, Jacquelyn A. Hank, Marguerite T. Parisi, Barry L. Shulkin, Malcolm Smith, Jeffrey A. Moscow, Hiroyuki Shimada, Katherine K. Matthay, Susan L. Cohn, John M. Maris, Rochelle Bagatell, Paul M. Sondel, Julie R. Park, Alice L. Yu
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 40(35)
PURPOSEPostconsolidation immunotherapy including dinutuximab, granulocyte-macrophage colony-stimulating factor, and interleukin-2 improved outcomes for patients with high-risk neuroblastoma enrolled on the randomized portion of Children's Oncology Gr
Autor:
Ami V Desai, Stefani Spranger, Thomas F Gajewski, Yuanyuan Zha, Riyue Bao, Jason J Luke, Peter Pytel, Kyle Hernandez, Samuel L Volchenboum, Susan L Cohn
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 7 (2021)
Background Tumor-infiltrating CD8+ T cells and neoantigens are predictors of a favorable prognosis and response to immunotherapy with checkpoint inhibitors in many types of adult cancer, but little is known about their role in pediatric malignancies.
Externí odkaz:
https://doaj.org/article/b260b4d6e43c4d658b87dc58bb5c263c
Autor:
Danielle Novetsky Friedman, Pamela J. Goodman, Wendy M. Leisenring, Lisa R. Diller, Susan L. Cohn, Rebecca M. Howell, Susan A. Smith, Emily S. Tonorezos, Suzanne L. Wolden, Joseph P. Neglia, Kirsten K. Ness, Todd M. Gibson, Paul C. Nathan, Brent R. Weil, Leslie L. Robison, Kevin C. Oeffinger, Gregory T. Armstrong, Charles A. Sklar, Tara O. Henderson
Publikováno v:
Journal of Clinical Oncology. 41:1565-1576
PURPOSE To describe the risk of late mortality, subsequent malignant neoplasms (SMNs), and chronic health conditions (CHCs) in survivors of neuroblastoma diagnosed in infancy by treatment era and exposures. METHODS Among 5-year survivors of neuroblas
Autor:
Anastasia E, Hains, Sakshi, Uppal, John Z, Cao, Helen R, Salwen, Mark A, Applebaum, Susan L, Cohn, Lucy A, Godley
Publikováno v:
Epigenetics. 17(13)
Ten-Eleven-Translocation 5-methylcytosine dioxygenases 1-3 (TET1-3) convert 5-methylcytosine to 5-hydroxymethylcytosine (5-hmC), using oxygen as a co-substrate. Contrary to expectations, hypoxia induces 5-hmC gains inIn