Výsledky vyhledávání - "Susan L. Bernstein"

Akademický článek

Advances in Understanding Carboxysome Assembly in Prochlorococcus and Synechococcus Implicate CsoS2 as a Critical Component

Autor: Fei Cai, Zhicheng Dou, Susan L. Bernstein, Ryan Leverenz, Eric B. Williams, Sabine Heinhorst, Jessup Shively, Gordon C. Cannon, Cheryl A. Kerfeld

Publikováno v: Life, Vol 5, Iss 2, Pp 1141-1171 (2015)

The marine Synechococcus and Prochlorococcus are the numerically dominant cyanobacteria in the ocean and important in global carbon fixation. They have evolved a CO2-concentrating-mechanism, of which the central component is the carboxysome, a self-a

Externí odkaz: https://doaj.org/article/66a803cd44354f8d824ed549dcc1f703

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An adaptive walk in the park

Autor: Felix Rico, Marianthi Karageorgi, Geno Guerra, Amy P. Hastings, Julianne N. Pelaez, Noah K. Whiteman, Kirsten I. Verster, Susanne Dobler, Fidan Sumbul, Simon C. Groen, Anurag Agrawal, Teruyuki Matsunaga, Jessica Aguilar, Susan L. Bernstein, Michael Astourian

Publikováno v: Nature
Nature, 2019, 574 (7778), pp.409-412. ⟨10.1038/s41586-019-1610-8⟩
Nature, Nature Publishing Group, 2019, 574 (7778), pp.409-412. ⟨10.1038/s41586-019-1610-8⟩
Nature, vol 574, iss 7778

Identifying the genetic mechanisms of adaptation requires the elucidation of links between the evolution of DNA sequence, phenotype, and fitness1. Convergent evolution can be used as a guide to identify candidate mutations that underlie adaptive trai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ddf8d89360638c1e4461d1fe7994cd8
https://doi.org/10.1038/s41576-019-0182-7

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Production and Characterization of Synthetic Carboxysome Shells with Incorporated Luminal Proteins

Autor: Fei, Cai, Susan L, Bernstein, Steven C, Wilson, Cheryl A, Kerfeld

Publikováno v: Plant physiology. 170(3)

Spatial segregation of metabolism, such as cellular-localized CO2 fixation in C4 plants or in the cyanobacterial carboxysome, enhances the activity of inefficient enzymes by selectively concentrating them with their substrates. The carboxysome and ot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5644402e566fe43c0cece2fe4f9734a5
https://pubmed.ncbi.nlm.nih.gov/26792123

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Advances in Understanding Carboxysome Assembly in Prochlorococcus and Synechococcus Implicate CsoS2 as a Critical Component

Autor: Sabine Heinhorst, Cheryl A. Kerfeld, Zhicheng Dou, Ryan L. Leverenz, Gordon C. Cannon, Susan L. Bernstein, Fei Cai, E. Williams, Jessup M. Shively

Publikováno v: Life; Volume 5; Issue 2; Pages: 1141-1171
Life, Vol 5, Iss 2, Pp 1141-1171 (2015)
Life

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b266b081182007a3e855e9468302596

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Engineering bacterial microcompartment shells: chimeric shell proteins and chimeric carboxysome shells

Autor: Susan L. Bernstein, James N. Kinney, Cheryl A. Kerfeld, Markus Sutter, Fei Cai

Publikováno v: ACS synthetic biology. 4(4)

Bacterial microcompartments (BMCs) are self-assembling organelles composed entirely of protein. Depending on the enzymes they encapsulate, BMCs function in either inorganic carbon fixation (carboxysomes) or organic carbon utilization (metabolosomes).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a02cfacf75b7ce108def59fc0e1a11
https://pubmed.ncbi.nlm.nih.gov/25117559

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Assembly of robust bacterial microcompartment shells using building blocks from an organelle of unknown function

Autor: Jonathan K. Lassila, Susan L. Bernstein, James N. Kinney, Cheryl A. Kerfeld, Seth D. Axen

Publikováno v: Journal of molecular biology. 426(11)

Bacterial microcompartments (BMCs) sequester enzymes from the cytoplasmic environment by encapsulation inside a selectively permeable protein shell. Bioinformatic analyses indicate that many bacteria encode BMC clusters of unknown function and with d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::963a8302cd2379d6aad7cffdb622fc30
https://pubmed.ncbi.nlm.nih.gov/24631000

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Towards Understanding Region-Specificity of Triplet Repeat Diseases: Coupled Immunohistology and Mass Spectrometry Imaging

Autor: Susan L. Bernstein, Ken A. Frankel, Cynthia T. McMurray, Do Yup Lee, Christie A. Canaria, Virginia Platt

Publikováno v: Methods in Molecular Biology ISBN: 9781627034104
Methods Mol Biol

Many trinucleotide repeat disorders exhibit region-specific toxicity within tissues, the basis of which cannot be explained by traditional methods. For example, in Huntington's Disease (HD), the toxic disease-causing protein is ubiquitously expressed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf601ada1f1e6f8ef6c36f02daa40528
https://doi.org/10.1007/978-1-62703-411-1_14

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Biochemical purification and crystallographic characterization of the fiber-forming protein pilin from Neisseria gonorrhoeae

Autor: Susan L. Bernstein, Elizabeth D. Getzoff, B. W. Kays, Hans E. Parge, Duncan E. McRee, M. A. Capozza, Christensen D, T. M. Fieser, C. D. Deal, Magdalene So, John A. Tainer, D. Draper

Publikováno v: Journal of Biological Chemistry. 265:2278-2285

Pilus fibers are long protein filaments on many pathogenic bacteria that participate in attachment to host cells. Although the self-assembling protein pilin is the major structural component of the Neisseria gonorrhoeae pilus fiber, several other pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf1fca6e0f1fe2d61844ebbb09ac56eb
https://doi.org/10.1016/s0021-9258(19)39972-7

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A mutation in the human cyclin-dependent kinase interacting protein, CksHs2, interferes with cyclin-dependent kinase binding and biological function, but preserves protein structure and assembly

Autor: Michael J. Hickey, Susan L. Bernstein, Alicia Santiago, Yves Bourne, Andrew S. Arvai, John A. Tainer, Steven I. Reed, Mark H. Watson

Publikováno v: Journal of molecular biology. 261(5)

A mutation directing an amino acid substitution in the conserved beta-hinge region of one of the human Cks isoforms, CksHs2, was constructed by site-directed mutagenesis. Replacement of glutamine for glutamate 63 (E63Q) was predicted to stabilize the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe8b8c6beb765d17d791839a1204e9cb
https://pubmed.ncbi.nlm.nih.gov/8800213

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Assembly and antigenicity of the Neisseria gonorrhoeae pilus mapped with antibodies

Autor: H M Geysen, Katrina T. Forest, Elizabeth D. Getzoff, John A. Tainer, C. D. Deal, G Tribbick, Susan L. Bernstein, Magdalene So

The relationship between the sequence of Neisseria gonorrhoeae pilin and its quaternary assembly into pilus fibers was studied with a set of site-directed antibody probes and by mapping the specificities of antipilus antisera with peptides. Buried an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c08ce3def28e97359f8cd2e89f937c4
https://europepmc.org/articles/PMC173814/

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