Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Susan L. Bernard"'
Autor:
Susan L. Bernard, Michael P. Hlastala, Axel Kleinsasser, Eric Falor, Nayak L. Polissar, Blazej Neradilek, Susan R. Hopkins, Alex Loeckinger
Publikováno v:
Journal of Applied Physiology. 103:2112-2119
Strenuous exercise combined with hypoxia is implicated in the development of high-altitude pulmonary edema (HAPE), which is believed to result from rupture of pulmonary capillaries secondary to high vascular pressures. The relative importance of hypo
Autor:
Jon R. Ewen, Jeffrey J. Kelly, Susan L. Bernard, David A. Frazer, Clyde H. Barlow, Robb W. Glenny, Steven McKinney
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 279:H2043-H2052
With the use of a newly developed Imaging Cryomicrotome to determine the spatial location of fluorescent microspheres in organs, we validate and report our processing algorithms for measuring regional blood flow in small laboratory animals. Microsphe
Autor:
Susan L. Bernard, Nayak L. Polissar, John W. Burns, Robb W. Glenny, Scott E. Sinclair, Don D. Sheriff, Michael P. Hlastala, Myron A. Chornuk
Publikováno v:
Journal of Applied Physiology. 89:445-457
We assessed the influence of cranial-to-caudal inertial force (+G z ) and the countermeasures of anti-G suit and positive pressure breathing during G (PBG), specifically during +G z , on regional pulmonary blood flow distribution. Unanesthetized swin
Publikováno v:
Journal of Applied Physiology. 89:499-504
The microsphere method has been used extensively to measure regional blood flow in large laboratory animals. A fundamental premise of the method is that microspheres do not alter regional flow or vascular tone. Whereas this assumption is accepted in
Publikováno v:
Review of Scientific Instruments. 71:228-234
An automated image acquisition and analysis system has been developed that rapidly determines regional blood flow by using the locations of fluorescent microspheres deposited in tissue. A motor-driven microtome removes sections of frozen tissues in s
Publikováno v:
Journal of Applied Physiology. 87:1931-1936
In regional lung injury, pulmonary blood flow decreases to the injured regions, and anastomotic bronchial blood flow and total bronchial blood flow increase. However, the pattern of redistribution of the two blood flows to the injured and noninjured
Publikováno v:
Journal of Applied Physiology. 86:623-632
Original studies leading to the gravitational model of pulmonary blood flow and contemporary studies showing gravity-independent perfusion differ in the recent use of laboratory animals instead of humans. We explored the distribution of pulmonary blo
Autor:
Nayak L. Polissar, Robb W. Glenny, Michael P. Hlastala, John W. Burns, Myron A. Chornuk, Susan L. Bernard, Harry J. Kallas, David A. Self
Publikováno v:
Journal of Applied Physiology. 84:1278-1288
This study was undertaken to assess the influence of gravity on the distribution of pulmonary blood flow (PBF) using increased inertial force as a perturbation. PBF was studied in unanesthetized swine exposed to −G x (dorsal-to-ventral direction, p
Publikováno v:
Biotechnic & Histochemistry. 73:291-309
We evaluated several histological methods and determined their advantages and disadvantages for histological studies of tissues and organs perfused with fluorescent microspheres. Microspheres retained their fluorescence in 7-10 microm serial sections
Autor:
Susan L. Bernard, Robb W. Glenny, Howard H. Erickson, Randall J. Basaraba, Nayak L. Polissar, Michael P. Hlastala, M. R. Fedde
Publikováno v:
Journal of Applied Physiology. 81:1062-1070
We determined the spatial distribution of pulmonary blood flow at rest and during increasing levels of exercise (34, 59, and 90% of maximal oxygen consumption) in Thoroughbred racehorses (n = 4) using 15-microns fluorescent microspheres. After the ho