Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Susan L Uprichard"'
Autor:
Louis Shekhtman, Miquel Navasa, Natasha Sansone, Gonzalo Crespo, Gitanjali Subramanya, Tje Lin Chung, E Fabian Cardozo-Ojeda, Sofía Pérez-del-Pulgar, Alan S Perelson, Scott J Cotler, Xavier Forns, Susan L Uprichard, Harel Dahari
Publikováno v:
eLife, Vol 10 (2021)
While the liver, specifically hepatocytes, are widely accepted as the main source of hepatitis C virus (HCV) production, the role of the liver/hepatocytes in clearance of circulating HCV remains unknown. Frequent HCV kinetic data were recorded and ma
Externí odkaz:
https://doaj.org/article/88ec9d007d544a56ba1441581f7bf611
Autor:
Laetitia Canini, Michio Imamura, Yoshiiku Kawakami, Susan L Uprichard, Scott J Cotler, Harel Dahari, Kazuaki Chayama
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0187409 (2017)
High cure rates are achieved in HCV genotype-1b patients treated with daclatasvir and asunaprevir, DCV/ASV. Here we analyzed early HCV kinetics in genotype-1b infected Japanese subjects treated with DCV/ASV and retrospectively projected, using mathem
Externí odkaz:
https://doaj.org/article/64ca034f152c450bb1e0bac67d197d0d
Autor:
Sarah Duehren, Takuro Uchida, Masataka Tsuge, Nobuhiko Hiraga, Susan L. Uprichard, Ohad Etzion, Jeffrey Glenn, Christopher Koh, Theo Heller, Scott J. Cotler, Shiro Oka, Kazuaki Chayama, Harel Dahari
Publikováno v:
Virus Research, Vol 349, Iss , Pp 199451- (2024)
Recent studies indicate that treatment of chronic hepatitis D virus (HDV) with either pegylated interferon (IFN)λ or pegylated IFNα monotherapy leads to a dramatic decline in HDV RNA. Herein, we investigated the innate antiviral efficacy of IFNλ a
Externí odkaz:
https://doaj.org/article/857a0b4422664920a2039f47a3fe44fd
Autor:
Shuchen Feng, Gail E. Reid, Nina M. Clark, Amanda Harrington, Susan L. Uprichard, Susan C. Baker
Publikováno v:
Virology Journal, Vol 21, Iss 1, Pp 1-13 (2024)
Abstract Background The factors contributing to the accelerated convergent evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are not fully understood. Unraveling the contribution of viral replication in immunocompromised patie
Externí odkaz:
https://doaj.org/article/150d1d5111f24842bda4ee3c3ee35626
Autor:
Hyun Lee, Tian Zhu, Kavankumar Patel, Yan-Yan Zhang, Lena Truong, Kirk E Hevener, Joseph L Gatuz, Gitanjali Subramanya, Hyun-Young Jeong, Susan L Uprichard, Michael E Johnson
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e75144 (2013)
Development of drug-resistant mutations has been a major problem with all currently developed Hepatitis C Virus (HCV) NS3/4A inhibitors, including the two FDA approved drugs, significantly reducing the efficacy of these inhibitors. The high incidence
Externí odkaz:
https://doaj.org/article/865643715fb8455293491e77012d45c1
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6561 (2009)
In 2005, the first robust hepatitis C virus (HCV) infectious cell culture system was developed based on the HCV genotype 2a JFH-1 molecular clone and the human-derived hepatoma cell line Huh7. Although much effort has been made to dissect and expand
Externí odkaz:
https://doaj.org/article/3f492ac70d0249339fec0986da045ffd
Publikováno v:
PLoS ONE, Vol 4, Iss 5, p e5489 (2009)
The host cellular factors that promote persistent viral infections in vivo are, in general, poorly understood. Utilizing the hepatitis B virus (HBV) transgenic mouse model of chronic infection, we demonstrate that the nuclear receptor, hepatocyte nuc
Externí odkaz:
https://doaj.org/article/6924b76b3dbb41ae939f3a500ed063d5
Autor:
Stephanie Maya, Leeor Hershkovich, E. Fabian Cardozo-Ojeda, Elham Shirvani-Dastgerdi, Jay Srinivas, Louis Shekhtman, Susan L. Uprichard, Andrew R. Berneshawi, Thomas R. Cafiero, Harel Dahari, Alexander Ploss
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT Chronic infection with hepatitis B and delta viruses (HDV) is the most serious form of viral hepatitis due to more severe manifestations of an accelerated progression to liver fibrosis, cirrhosis, and hepatocellular carcinoma. We characteriz
Externí odkaz:
https://doaj.org/article/b9fcc73b41b943d28bbce73d71cfd85d
Autor:
Shuchen Feng, Mudassir S. Ali, Monika Evdokimova, Gail E. Reid, Nina M. Clark, Susan L. Uprichard, Susan C. Baker
Publikováno v:
Viruses, Vol 14, Iss 7, p 1408 (2022)
The pandemic of SARS-CoV-2 is characterized by the emergence of new variants of concern (VOCs) that supplant previous waves of infection. Here, we describe our investigation of the lineages and host-specific mutations identified in a particularly vul
Externí odkaz:
https://doaj.org/article/bb6f83e1d62f4002b120127608df95b9
Autor:
Susan L. Uprichard, Amornrat O’Brien, Monika Evdokimova, Cynthia L. Rowe, Cara Joyce, Matthew Hackbart, Yazmin E. Cruz-Pulido, Courtney A. Cohen, Michelle L. Rock, John M. Dye, Paul Kuehnert, Keersten M. Ricks, Marybeth Casper, Lori Linhart, Katrina Anderson, Laura Kirk, Jack A. Maggiore, Andrew S. Herbert, Nina M. Clark, Gail E. Reid, Susan C. Baker
Publikováno v:
Viruses, Vol 14, Iss 2, p 370 (2022)
Understanding the magnitude of responses to vaccination during the ongoing SARS-CoV-2 pandemic is essential for ultimate mitigation of the disease. Here, we describe a cohort of 102 subjects (70 COVID-19-naïve, 32 COVID-19-experienced) who received
Externí odkaz:
https://doaj.org/article/570717b62a8c4ca08e9497cd79588a89