Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Susan L Levinson"'
Autor:
Nicole Noren Hooten, Nicolle A. Mode, Edward Kowalik, Victor Omoniyi, Alan B. Zonderman, Ngozi Ezike, Mark J. DiNubile, Susan L. Levinson, Michele K. Evans
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-10 (2023)
Abstract Background The growing epidemic of the inflammation-related metabolic disease, type 2 diabetes mellitus, presents a challenge to improve our understanding of potential mechanisms or biomarkers to prevent or better control this age-associated
Externí odkaz:
https://doaj.org/article/adb485c651df4871839784531ae297ab
Autor:
Michael S. Abers, Ottavia M. Delmonte, Emily E. Ricotta, Jonathan Fintzi, Danielle L. Fink, Adriana A. Almeida de Jesus, Kol A. Zarember, Sara Alehashemi, Vasileios Oikonomou, Jigar V. Desai, Scott W. Canna, Bita Shakoory, Kerry Dobbs, Luisa Imberti, Alessandra Sottini, Eugenia Quiros-Roldan, Francesco Castelli, Camillo Rossi, Duilio Brugnoni, Andrea Biondi, Laura Rachele Bettini, Mariella D’Angio’, Paolo Bonfanti, Riccardo Castagnoli, Daniela Montagna, Amelia Licari, Gian Luigi Marseglia, Emily F. Gliniewicz, Elana Shaw, Dana E. Kahle, Andre T. Rastegar, Michael Stack, Katherine Myint-Hpu, Susan L. Levinson, Mark J. DiNubile, Daniel W. Chertow, Peter D. Burbelo, Jeffrey I. Cohen, Katherine R. Calvo, John S. Tsang, NIAID COVID-19 Consortium, Helen C. Su, John I. Gallin, Douglas B. Kuhns, Raphaela Goldbach-Mansky, Michail S. Lionakis, Luigi D. Notarangelo
Publikováno v:
JCI Insight, Vol 6, Iss 1 (2021)
Immune and inflammatory responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contribute to disease severity of coronavirus disease 2019 (COVID-19). However, the utility of specific immune-based biomarkers to predict clinical outc
Externí odkaz:
https://doaj.org/article/feaeec76ff49437f8d320c0de85e7c30
Autor:
Stephen R. Thom, Veena M. Bhopale, Awadhesh K. Arya, Deepa Ruhela, Abid R. Bhat, Nandita Mitra, Ole Hoffstad, D. Scot Malay, Ziad K. Mirza, John C. Lantis, Hadar A. Lev-Tov, Robert S. Kirsner, Ru-Ching Hsia, Susan L. Levinson, Mark J. DiNubile, David J. Margolis
Publikováno v:
ImmunoHorizons. 7:71-80
The proinflammatory state associated with diabetes mellitus (DM) remains poorly understood. We found patients with DM have 3- to 14-fold elevations of blood-borne microparticles (MPs) that bind phalloidin (Ph; Ph positive [+] MPs), indicating the pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6569d4284337aad8a2a36564f6130aa
https://doi.org/10.4049/immunohorizons.2200099
https://doi.org/10.4049/immunohorizons.2200099
Publikováno v:
Open forum infectious diseases. 9(8)
Background Excessive inflammation contributes to the morbidity and mortality of severe coronavirus disease 2019 (COVID-19) pneumonia. Recombinant human plasma gelsolin (rhu-pGSN) improves disease outcomes in diverse experimental models of infectious
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c96ed9d08161ea692cd702876064d1
https://pubmed.ncbi.nlm.nih.gov/35928505
https://pubmed.ncbi.nlm.nih.gov/35928505
Background Biomarkers are needed for frailty, a common phenotype often associated with muscle loss in older people. Plasma gelsolin (pGSN) is a protein largely synthesized and secreted by skeletal muscle. Aims To investigate whether pGSN could be a b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25efecd6402b13f54b2bf1a691d9582f
http://hdl.handle.net/10138/345171
http://hdl.handle.net/10138/345171
Autor:
Kol A. Zarember, John I. Gallin, Douglas B. Kuhns, Hanna S Hong, Harry L. Malech, Gal Wald, Robert J. Noveck, Emily F. Gliniewicz, John Audley, Thomas P. Stossel, Susan L Levinson, Mark J. DiNubile, Anthony F. Suffredini, Elizabeth M. Kang
Publikováno v:
Inflammation. 44:270-277
Plasma gelsolin (pGSN) is the secreted isoform of an intracellular actin remodeling protein found in high concentrations in human plasma. Clinical studies demonstrate reduced pGSN concentrations in several disease states, including severe trauma, bur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d314f2f8472e7f7296198651b7df2fe
https://doi.org/10.1007/s10753-020-01330-w
https://doi.org/10.1007/s10753-020-01330-w
Publikováno v:
Aging clinical and experimental research. 34(5)
Biomarkers are needed for frailty, a common phenotype often associated with muscle loss in older people. Plasma gelsolin (pGSN) is a protein largely synthesized and secreted by skeletal muscle.To investigate whether pGSN could be a biomarker of the f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::408fbf81f6453418464206aaf7b792be
https://pubmed.ncbi.nlm.nih.gov/35169987
https://pubmed.ncbi.nlm.nih.gov/35169987
Autor:
Mark J. DiNubile, Quan Lu, Zhiping Yang, Susan L Levinson, Alice Bedugnis, Thomas P. Stossel, Lester Kobzik
Publikováno v:
J Infect Dis
Therapy to enhance host immune defenses may improve outcomes in serious infections, especially for antibiotic-resistant pathogens. Recombinant human plasma gelsolin (rhu-pGSN), a normally circulating protein, has beneficial effects in diverse preclin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef5b360656c544283749053a4b4c17ae
https://doi.org/10.1093/infdis/jiz353
https://doi.org/10.1093/infdis/jiz353
Autor:
Susan L Levinson, Veena M. Bhopale, Nathan Z. Nugent, Deepa Ruhela, Stephen R. Thom, Mark J. DiNubile, Kaighley D. Brett, Noelle K. Fraser
Publikováno v:
J Appl Physiol (1985)
Plasma gelsolin (pGSN) levels fall in association with diverse inflammatory conditions. We hypothesized that pGSN would decrease due to the stresses imposed by high pressure and subsequent decompression, and repletion would ameliorate injuries in a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b78c14903edf3bd9e8aae1a2bec8572
https://pubmed.ncbi.nlm.nih.gov/33764168
https://pubmed.ncbi.nlm.nih.gov/33764168
Publikováno v:
Antimicrob Agents Chemother
There remains an unmet need to address the substantial morbidity and mortality associated with severe community-acquired pneumonia (sCAP). Recombinant human plasma gelsolin (rhu-pGSN) improves disease outcomes in diverse animal models of infectious a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47d52d7f45be496b12b7a999ce084813
https://doi.org/10.1128/aac.00579-20
https://doi.org/10.1128/aac.00579-20