Zobrazeno 1 - 10
of 260
pro vyhledávání: '"Susan K. Pierce"'
Autor:
Nginache Nampota-Nkomba, Osward M. Nyirenda, Jane Mallewa, Yamikani Chimalizeni, Nettie Dzabala, Michael P. Fay, Mathangi Gopalakrishnan, Matthew B. Laurens, Nicole F. O’Brien, Louis H. Miller, Susan K. Pierce, Brittany A. Riggle, Douglas G. Postels
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-17 (2024)
Abstract Background Despite treatment with highly effective antimalarial drugs, malaria annually claims the lives of over half a million children under 5-years of age in sub-Saharan Africa. Cerebral malaria (CM), defined as Plasmodium falciparum infe
Externí odkaz:
https://doaj.org/article/db9455a78ade4c80b6bcd3739bf6018c
Autor:
Clare K. Cimperman, Mirna Pena, Sohret M. Gokcek, Brandon P. Theall, Meha V. Patel, Anisha Sharma, ChenFeng Qi, Daniel Sturdevant, Louis H. Miller, Patrick L. Collins, Susan K. Pierce, Munir Akkaya
Publikováno v:
mBio, Vol 14, Iss 2 (2023)
ABSTRACT Cerebral malaria (CM), the deadliest complication of Plasmodium infection, is a complex and unpredictable disease. However, our understanding of the host and parasite factors that cause CM is limited. Using a mouse model of CM, experimental
Externí odkaz:
https://doaj.org/article/3261caae55db47f9969e701fac6f0d4d
Autor:
Ben S. Wendel, Chenfeng He, Mingjuan Qu, Di Wu, Stefany M. Hernandez, Ke-Yue Ma, Eugene W. Liu, Jun Xiao, Peter D. Crompton, Susan K. Pierce, Pengyu Ren, Keke Chen, Ning Jiang
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Somatic hypermutation of antibodies can occur in infants but are difficult to track. Here the authors present a new method called MIDCIRS for deep quantitative repertoire sequencing with few cells, and show infants as young as 3 months can expand ant
Externí odkaz:
https://doaj.org/article/e3859fc7336a44ffae74cb5a14acbd04
Autor:
Prakash Srinivasan, G. Christian Baldeviano, Kazutoyo Miura, Ababacar Diouf, Julio A. Ventocilla, Karina P. Leiva, Luis Lugo-Roman, Carmen Lucas, Sachy Orr-Gonzalez, Daming Zhu, Eileen Villasante, Lorraine Soisson, David L. Narum, Susan K. Pierce, Carole A. Long, Carter Diggs, Patrick E. Duffy, Andres G. Lescano, Louis H. Miller
Publikováno v:
npj Vaccines, Vol 2, Iss 1, Pp 1-10 (2017)
Malaria: Inhibiting parasite invasion of red blood cells A vaccine targeting a protein complex that allows malaria-causing parasite to enter red blood cells has been produced. Malaria caused by the parasite Plasmodium falciparum is an oft-deadly infe
Externí odkaz:
https://doaj.org/article/d9c88e0c86564a8eab352c28fd19d3b2
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Malaria is a deadly infectious disease associated with fundamental changes in the composition of the memory B cell (MBC) compartment, most notably a large expansion of T-bet+ MBCs, termed atypical MBCs. However, we know little about the precursors of
Externí odkaz:
https://doaj.org/article/5c5cfc39160345f482030c6652c46795
Publikováno v:
F1000Research, Vol 6 (2017)
Cerebral malaria is the deadliest complication of malaria, a febrile infectious disease caused by Plasmodium parasite. Any of the five human Plasmodium species can cause disease, but, for unknown reasons, in approximately 2 million cases each year P.
Externí odkaz:
https://doaj.org/article/ee367001138c4251aeb037501aafc1c8
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Advancements in high-throughput sequencing and molecular identifier-based error correction have opened the door to antibody repertoire sequencing with single mutation precision, increasing both the breadth and depth of immune response characterizatio
Externí odkaz:
https://doaj.org/article/73794e08e4134b2c9319ecfefc348ce8
Inhibiting the Mammalian Target of Rapamycin Blocks the Development of Experimental Cerebral Malaria
Autor:
Emile B. Gordon, Geoffrey T. Hart, Tuan M. Tran, Michael Waisberg, Munir Akkaya, Jeff Skinner, Severin Zinöcker, Mirna Pena, Takele Yazew, Chen-Feng Qi, Louis H. Miller, Susan K. Pierce
Publikováno v:
mBio, Vol 6, Iss 3 (2015)
ABSTRACT Malaria is an infectious disease caused by parasites of several Plasmodium spp. Cerebral malaria (CM) is a common form of severe malaria resulting in nearly 700,000 deaths each year in Africa alone. At present, there is no adjunctive therapy
Externí odkaz:
https://doaj.org/article/d9d29f731e7d438284e52153462fb045
Autor:
Clare K. Cimperman, Mirna Pena, Sohret M. Gokcek, Brandon P. Theall, Meha V. Patel, Anisha Sharma, ChenFeng Qi, Daniel Sturdevant, Louis H. Miller, Patrick L Collins, Susan K. Pierce, Munir Akkaya
Cerebral Malaria (CM), the deadliest complication ofPlasmodiuminfection, is a complex and unpredictable disease. However, our understanding of the host and parasite factors that cause CM is limited. Using a mouse model of CM, experimental CM (ECM), w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e48bc41d815ba2f783e94cf8e4f98409
https://doi.org/10.1101/2022.11.23.517617
https://doi.org/10.1101/2022.11.23.517617
Autor:
Pavel Tolar, Susan K. Pierce
Publikováno v:
Science (New York, N.Y.). 377(6608)
Molecular structures provide a road map for understanding and controlling B cell receptor activation