Zobrazeno 1 - 10
of 169
pro vyhledávání: '"Susan K. Fried"'
Autor:
Sanil Patel, Khatanzul Ganbold, Chung Hwan Cho, Juwairriyyah Siddiqui, Ramazan Yildiz, Njeri Sparman, Shani Sadeh, Christy M. Nguyen, Jiexin Wang, Julian P. Whitelegge, Susan K. Fried, Hironori Waki, Claudio J. Villanueva, Marcus M. Seldin, Shinya Sakaguchi, Wilfried Ellmeier, Peter Tontonoz, Prashant Rajbhandari
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract White adipose tissue (WAT) is essential for lipid storage and systemic energy homeostasis. Understanding adipocyte formation and stability is key to developing therapies for obesity and metabolic disorders. Through a high-throughput cDNA scr
Externí odkaz:
https://doaj.org/article/f18f20fa0edf4a6cae7060030104db86
Autor:
Marcella E. O’Reilly, Sebastian Ho, Johana Coronel, Lucie Zhu, Wen Liu, Chenyi Xue, Eunyoung Kim, Esther Cynn, Caio V. Matias, Rajesh Kumar Soni, Chen Wang, Iuliana Ionita-Laza, Robert C. Bauer, Leila Ross, Yiying Zhang, Silvia Corvera, Susan K. Fried, Muredach P. Reilly
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114240- (2024)
Summary: Adipose tissue remodeling and dysfunction, characterized by elevated inflammation and insulin resistance, play a central role in obesity-related development of type 2 diabetes (T2D) and cardiovascular diseases. Long intergenic non-coding RNA
Externí odkaz:
https://doaj.org/article/577c9a29704b4b8ca143497013362bb5
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 4, Pp 856-868 (2019)
Treatment with PPARγ agonists in vivo improves human adipocyte metabolism, but the cellular mechanisms and possible depot differences in responsiveness to their effects are poorly understood. To examine the ex vivo metabolic effects of rosiglitazone
Externí odkaz:
https://doaj.org/article/f6f4333fcb0342dea96af3fd0e2a57a4
Autor:
Bingyao Wang, Gregory Smith, Frederique Ruf-Zamojski, Gyu Ho Lee, Stuart C. Sealfon, Jeanine Albu, Susan K. Fried, Kalypso Karastergiou
Publikováno v:
Journal of Clinical and Translational Science, Vol 5, Pp 4-5 (2021)
ABSTRACT IMPACT: Characterizing the cellular composition of human adipose tissue may contribute to the prevention and/or treatment of obesity-associated metabolic diseases. OBJECTIVES/GOALS: Our aims in this study were to use single-cell techniques 1
Externí odkaz:
https://doaj.org/article/99f4f226a40444b284a265ad9074b417
Autor:
Mi-Jeong Lee, Susan K. Fried
Publikováno v:
Journal of Obesity & Metabolic Syndrome, Vol 26, Iss 3, Pp 172-180 (2017)
Men and women are different in their fat mass and distribution pattern. The gynoid-type fat distribution, accumulation in lower-body, is considered to be protective while the android-type accumulation in upper-body, both in abdominal subcutaneous and
Externí odkaz:
https://doaj.org/article/cac7ab0952c048f9936a042eb5f1236a
Autor:
Carly T. Cederquist, Claudia Lentucci, Camila Martinez-Calejman, Vanessa Hayashi, Joseph Orofino, David Guertin, Susan K. Fried, Mi-Jeong Lee, M. Dafne Cardamone, Valentina Perissi
Publikováno v:
Molecular Metabolism, Vol 6, Iss 1, Pp 125-137 (2017)
Objective: Insulin signaling plays a unique role in the regulation of energy homeostasis and the impairment of insulin action is associated with altered lipid metabolism, obesity, and Type 2 Diabetes. The main aim of this study was to provide further
Externí odkaz:
https://doaj.org/article/7f556202953b471f96a598be63c200e9
Autor:
Mi-Jeong Lee, Rong-Ze Yang, Kalypso Karastergiou, Steven R. Smith, Jeffery R. Chang, Da-Wei Gong, Susan K. Fried
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 7, Pp 1256-1263 (2016)
The glucocorticoid-induced leucine zipper (GILZ), a primary target of glucocorticoids, is expressed in human adipocytes, but its importance in adipocyte function is unknown. Because TNFα is increased in obese adipose tissue and antagonizes a number
Externí odkaz:
https://doaj.org/article/e779afc8b51f483987e5f4649d532d57
Autor:
Mark P. Jedrychowski, Libin Liu, Collette J. Laflamme, Kalypso Karastergiou, Tova Meshulam, Shi-Ying Ding, Yuanyuan Wu, Mi-Jeong Lee, Steven P. Gygi, Susan K. Fried, Paul F. Pilch
Publikováno v:
Molecular Metabolism, Vol 4, Iss 11, Pp 758-770 (2015)
Objective: Adipocytes are robust protein secretors, most notably of adipokines, hormone-like polypeptides, which act in an endocrine and paracrine fashion to affect numerous physiological processes such as energy balance and insulin sensitivity. To u
Externí odkaz:
https://doaj.org/article/a3dc06a4d9be427492c6dea1f64ccac4
Autor:
Susan K. Fried, Thomas Tittelbach, Jacob Blumenthal, Urmila Sreenivasan, Linda Robey, Jamie Yi, Sumbul Khan, Courtney Hollender, Alice S. Ryan, Andrew P. Goldberg
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 5, Pp 1193-1200 (2010)
High fatty acid (FA) flux is associated with systemic insulin resistance, and African-American (AA) women tend to be more insulin resistant. We assessed possible depot and race difference in the antilipolytic effect of insulin in adipocytes isolated
Externí odkaz:
https://doaj.org/article/82d321c36579484d92481d6f38181a3b
Autor:
Mi-Jeong Lee, Susan K. Fried
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 9, Pp 1984-1993 (2006)
The mechanisms of the increased serum leptin in response to feeding are poorly understood. Therefore, we used metabolic labeling to directly assess leptin biosynthesis, secretion, and turnover in adipose tissue from 14 h-starved compared with fed 12
Externí odkaz:
https://doaj.org/article/64280959650e4524ac4dbab4ebb0d866