Výsledky vyhledávání - "Susan K. Dunn"

A randomized controlled trial evaluating recovery and survival of 6% dimethyl sulfoxide-frozen autologous platelets in healthy volunteers

Autor: Larry J. Dumont, D. Nicole Worsham, Deborah F. Dumont, Victor W. Macdonald, Janet H. Ransom, Margaret O'Leary, Zbigniew M. Szczepiorkowski, Alan Siegel, Jose A. Cancelas, Elizabeth L. Hartman, P. Gayle Pratt, Rodney A. Michael, Susan K. Dunn, Neeta Rugg

Publikováno v: Transfusion. 53:128-137

BACKGROUND: Availability of platelets (PLTs) is severely limited by shelf life in some settings. Our objective was to determine and compare to Food and Drug Administration (FDA) criteria the PLT recovery and survival of autologous PLTs cryopreserved

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::220a012506d56409c5590a79f8fc57a3
https://doi.org/10.1111/j.1537-2995.2012.03735.x

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Connexin-43 in the osteogenic BM niche regulates its cellular composition and the bidirectional traffic of hematopoietic stem cells and progenitors

Autor: Matthias Gunzer, David E. Gutstein, Daniel González-Nieto, Malav Madhu, Jose A. Cancelas, Gabriel Ghiaur, Luis C. Barrio, Rebecca A. Santho, Susan K. Dunn, Anja Köhler, Lina Li, Amitava Sengupta, Roberto Civitelli, Eri Ishikawa, Glenn I. Fishman, Jorden Arnett

Publikováno v: Blood, ISSN 0006-4971, 2012-05, Vol. 119, No. 22
Archivo Digital UPM
Universidad Politécnica de Madrid

Connexin-43 (Cx43), a gap junction protein involved in control of cell proliferation, differentiation and migration, has been suggested to have a role in hematopoiesis. Cx43 is highly expressed in osteoblasts and osteogenic progenitors (OB/P). To elu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3388ad9917729d4e22b10746ed631b33
https://doi.org/10.1182/blood-2011-07-368506

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Atypical protein kinase C (aPKCζ and aPKCλ) is dispensable for mammalian hematopoietic stem cell activity and blood formation

Autor: Jose A. Cancelas, Jorge Moscat, Hartmut Geiger, Maria Carolina Florian, Eri Ishikawa, Ashley M. Ficker, Maria T. Diaz-Meco, Susan K. Dunn, Angeles Duran, Michael Leitges, Amitava Sengupta

Publikováno v: Proceedings of the National Academy of Sciences. 108:9957-9962

The stem-cell pool is considered to be maintained by a balance between symmetric and asymmetric division of stem cells. The cell polarity model proposes that the facultative use of symmetric and asymmetric cell division is orchestrated by a polarity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d12395bb9167ed5250a0bd919b4f0834
https://doi.org/10.1073/pnas.1103132108

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In vivo viability of stored red blood cells derived from riboflavin plus ultraviolet light-treated whole blood

Autor: Heather L. Reddy, Jose A. Cancelas, Susan K. Dunn, Susanne Marschner, P. Gayle Pratt, Dana Fletcher, Raymond P. Goodrich, D. Nicole Worsham, Neeta Rugg

Publikováno v: Transfusion. 51:1460-1468

BACKGROUND: A novel system using ultraviolet (UV) light and riboflavin (Mirasol System, CaridianBCT Biotechnologies) to fragment nucleic acids has been developed to treat whole blood (WB), aiming at the reduction of potential pathogen load and white

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b4dc1fb86657eae536a87a23d1d629d
https://doi.org/10.1111/j.1537-2995.2010.03027.x

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Rac2 GTPase deficiency depletes BCR-ABL+ leukemic stem cells and progenitors in vivo

Autor: Susan K. Dunn, Jose A. Cancelas, Amitava Sengupta, David A. Williams, Jorden Arnett

Publikováno v: Blood. 116:81-84

Chronic myelogenous leukemia (CML) is a clonal myeloproliferative disease (MPD) initiated by p210-BCR-ABL–mediated transformation of hematopoietic stem cells (HSCs). Inhibition of the ABL kinase alone is not sufficient to eradicate leukemic stem ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a36f7671e2dfda9b87f9e273ee399b4
https://doi.org/10.1182/blood-2009-10-247437

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Klf5 controls bone marrow homing of stem cells and progenitors through Rab5-mediated β1/β2-integrin trafficking

Autor: Ramesh C. Nayak, H. A. Olsson, Malav Madhu, Amitava Sengupta, Ashley M. Ficker, Jose A. Cancelas, H. L. Grimes, Susan K. Dunn, Kyung Hee Chang, Jeffrey A. Whitsett, E. Taniguchi Ishikawa

Publikováno v: Nature communications

Krüppel-like factor 5 regulates pluripotent stem cell self-renewal, but its role in somatic stem cells is unknown. Here we show that Krüppel-like factor 5-deficient haematopoietic stem cells and progenitors fail to engraft after transplantation. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc77d79c8ff78328dc7f3aaab1c9acd8
https://doi.org/10.1038/ncomms2645

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Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival

Autor: Ashley M. Ficker, Xosé R. Bustelo, Shuhong Shen, Susan K. Dunn, Rebecca A. Santho, Amitava Sengupta, David A. Williams, Abel Sanchez-Aguilera, Jose A. Cancelas, Yi Zheng, Michael W. Deininger, Malav Madhu, Xabier Agirre, Jorden Arnett, John P. Perentesis, Kyung Hee Chang, Ashley M. Kuenzi

Publikováno v: Dadun. Depósito Académico Digital de la Universidad de Navarra
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Blood; Vol 120

Despite the introduction of tyrosine kinase inhibitor therapy, the prognosis for p190-BCR-ABL+ acute lymphoblastic leukemia remains poor. In the present study, we present the cellular and molecular roles of the Rho GTPase guanine nucleotide exchange

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89bb79e67ed950197b4c411ac2f78f14
https://hdl.handle.net/10171/36318

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A randomized controlled trial evaluating recovery and survival of 6% dimethyl sulfoxide-frozen autologous platelets in healthy volunteers

Autor: Larry J, Dumont, Jose A, Cancelas, Deborah F, Dumont, Alan H, Siegel, Zbigniew M, Szczepiorkowski, Neeta, Rugg, P Gayle, Pratt, D Nicole, Worsham, Elizabeth L, Hartman, Susan K, Dunn, Margaret, O'Leary, Janet H, Ransom, Rodney A, Michael, Victor W, Macdonald

Publikováno v: Transfusion. 53(1)

Availability of platelets (PLTs) is severely limited by shelf life in some settings. Our objective was to determine and compare to Food and Drug Administration (FDA) criteria the PLT recovery and survival of autologous PLTs cryopreserved at -65°C or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::019e562532115e7eb5de5b179b685c00
https://pubmed.ncbi.nlm.nih.gov/22671278

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Bmi1 reprograms CML B-lymphoid progenitors to become B-ALL-initiating cells

Autor: Jose A. Cancelas, Malav Madhu, Amitava Sengupta, Susan K. Dunn, Ashley M. Ficker

Publikováno v: Blood. 119(2)

The characterization and targeting of Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia (ALL)–initiating cells remains unresolved. Expression of the polycomb protein Bmi1 is up-regulated in patients with advanced stages of chronic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dac6715371909b8123fe0a21632328fe
https://pubmed.ncbi.nlm.nih.gov/22101899

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