Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Susan Johnghar"'
Autor:
Kenneth E. Carlson, Olafur S. Gudmundsson, Bruce A. Ellsworth, Philip M. Sher, Susan Harvey, Eva Zuvich, Michael Thomas, William J. Keim, Gang Wu, Helen E. Godonis, Paul Stetsko, Brian J. Murphy, Richard B. Sulsky, Guixue Yu, William R. Ewing, Mary Jane Cullen, Mary Ann Pelleymounter, Doree F. Sitkoff, Susan Johnghar, Zhengxiang Gu, Ximao Wu, James Devenny, Rose Ann F Baska, Asoka Ranasinghe, Ning Lee, Kamelia Behnia, Anthony V. Azzara, Kenneth W. Rohrbach, Gerry Everlof, Liya Kang, Natesan Murugesan, Yeheng Zhu, Yifan Yang
Publikováno v:
Journal of Medicinal Chemistry. 56:9586-9600
Several strategies have been employed to reduce the long in vivo half-life of our lead CB1 antagonist, triazolopyridazinone 3, to differentiate the pharmacokinetic profile versus the lead clinical compounds. An in vitro and in vivo clearance data set
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::417c836ddf3010c89cd9792afb3349b0
https://doi.org/10.1021/jm4010835
https://doi.org/10.1021/jm4010835
Autor:
Petia Shipkova, James P. Wojciechowski, Punit Marathe, Robert Paul Brigance, Kamelia Behnia, Andrew Henwood, Georgia Cornelius, Susan Johnghar, Jian Wang, A. David Rodrigues, Paul Stetsko, W. Griffith Humphreys, William N. Washburn
Publikováno v:
Chemical Research in Toxicology. 24:905-912
The development of compounds with the potential for genotoxicity poses significant safety risks as well as risks of attrition. Although genotoxicity evaluation of the parent molecule is routine and reasonably predictive, assessing the risk of commerc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efab317cb863dfe887e0c4c93a4bb7be
https://doi.org/10.1021/tx200087q
https://doi.org/10.1021/tx200087q
Autor:
Kenneth E. Carlson, Mary Ann Pelleymounter, William J. Keim, Susan Johnghar, Keith J. Miller, Eva O’Tanyi, Yuan Tian, Kamelia Behnia, Kenneth W. Rohrbach, William R. Ewing, Zhengxiang Gu, Yang Hong, Natesan Murugesan, Yeheng Zhu, Yifan Yang
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(22)
Obesity remains a significant public health issue leading to Type II diabetes and cardiovascular disease. CB1 antagonists have been shown to suppress appetite and reduce body weight in animal models as well as in humans. Evaluation of pre-clinical CB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d69fc7157c55d272dc6ecaa356b40ded
https://pubmed.ncbi.nlm.nih.gov/21962575
https://pubmed.ncbi.nlm.nih.gov/21962575
Autor:
Kenneth E. Carlson, Yeheng Zhu, Yifan Yang, William R. Ewing, Rose Ann F Baska, Ying Wang, Bruce A. Ellsworth, Qi Huang, Samuel Gerritz, Susan Johnghar, Neil T. Burford, William N. Washburn, Mary Ann Pelleymounter, Chongqing Sun, Kamelia Behnia, Annapurna Pendri, Liya Kang, Mary Jane Cullen
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(14)
Structure-activity relationships for a series of pyrazine carboxamide CB1 antagonists are reported. Pharmaceutical properties of the series are improved via inclusion of hydroxyl-containing sidechains. This structural modification sufficiently improv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f57f9edbb7ac26768e1169d4ee8450d3
https://pubmed.ncbi.nlm.nih.gov/17513109
https://pubmed.ncbi.nlm.nih.gov/17513109
Autor:
Kamelia Behnia, Georgia Cornelius, Jian Wang, Petia Shipkova, Susan Johnghar, William Washburn, Robert Brigance, Paul Stetsko, Andrew Henwood, James P. Wojciechowski, Punit Marathe, A. David Rodrigues, W. Griffith Humphreys
Publikováno v:
Chemical Research in Toxicology; Jun2011, Vol. 24 Issue 6, p905-912, 8p