Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Susan Jiang"'
1
Akademický článek
NMR analysis of the correlation of metabolic changes in blood and cerebrospinal fluid in Alzheimer model male and female mice.
Autor: Filip Stojanovic, Mariam Taktek, Nam Huan Khieu, Junzhou Huang, Susan Jiang, Kerry Rennie, Balu Chakravarthy, Will J Costain, Miroslava Cuperlovic-Culf
Publikováno v: PLoS ONE, Vol 16, Iss 5, p e0250568 (2021)
The development of effective therapies as well as early, molecular diagnosis of Alzheimer's disease is impeded by the lack of understanding of the underlying pathological mechanisms. Metabolomics studies of body fluids as well as brain tissues have s
Externí odkaz: https://doaj.org/article/7ca410966c494c238d0e4caf8e431b64
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2
Serum albumin‐binding V H Hs with variable pH sensitivities enable tailored half‐life extension of biologics
Autor: Kevin A. Henry, Shalini Raphael, Henk van Faassen, Qingling Yang, Martin A Rossotti, Shannon Ryan, Susan Jiang, Eric Brunette, C. Roger MacKenzie, Traian Sulea, Arsalan S. Haqqani, Greg Hussack, Jamshid Tanha
Publikováno v: The FASEB Journal. 34:8155-8171
Prolonged serum half-life is required for the efficacy of most protein therapeutics. One strategy for half-life extension is to exploit the long circulating half-life of serum albumin by incorporating a binding moiety that recognizes albumin. Here, w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a18b062f15541be828a00df429717a65
https://doi.org/10.1096/fj.201903231r
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4
NMR Analysis of the Correlation of Metabolic Changes in Blood and Cerebrospinal Fluid in Alzheimer Model Male and Female Mice
Autor: Nam Huan Khieu, Filip Stojanovic, Kerry Rennie, Will J. Costain, Junzhou Huang, Miroslava Cuperlovic-Culf, Susan Jiang, Mariam Taktek, Balu Chakravarthy
Publikováno v: PLoS ONE, Vol 16, Iss 5, p e0250568 (2021)
PLoS ONE
The development of effective therapies as well as early, molecular diagnosis of Alzheimer’s disease is impeded by the lack of understanding of the underlying pathological mechanisms. Metabolomics studies of body fluids as well as brain tissues have
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::831bcb56d451c0ce4335d7f26b662133
https://doi.org/10.1101/2020.05.26.116525
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5
Serum albumin-binding V
Autor: Henk, van Faassen, Shannon, Ryan, Kevin A, Henry, Shalini, Raphael, Qingling, Yang, Martin A, Rossotti, Eric, Brunette, Susan, Jiang, Arsalan S, Haqqani, Traian, Sulea, C Roger, MacKenzie, Jamshid, Tanha, Greg, Hussack
Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 34(6)
Prolonged serum half-life is required for the efficacy of most protein therapeutics. One strategy for half-life extension is to exploit the long circulating half-life of serum albumin by incorporating a binding moiety that recognizes albumin. Here, w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::83e8751130d9dd2d2716cf1a831976da
https://pubmed.ncbi.nlm.nih.gov/32342547
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7
A novel platform for engineering blood-brain barrier-crossing bispecific biologics
Autor: Giovanna Antognetti, William P. Sisk, Arsalan S. Haqqani, Eve Boileau, John Eldredge, Wen Ding, Ewa Baumann, Pepinsky R Blake, Graham K. Farrington, Danica Stanimirovic, Ellen Garber, Nadia L. Caram-Salas, Eric Brunette, Christie Delaney, Susan Jiang
Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 28(11)
The blood-brain barrier (BBB) prevents the access of therapeutic antibodies to central nervous system (CNS) targets. The engineering of bispecific antibodies in which a therapeutic "arm" is combined with a BBB-transcytosing arm can significantly enha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c377da1d76b1d1100774ace351491a74
https://pubmed.ncbi.nlm.nih.gov/25070367
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8
Cocaine enhances HIV-1 gp120-induced lymphatic endothelial dysfunction in the lung
Autor: Susan Jiang, Paula M. Kuzontkoski, Jerome E. Groopman, Xuefeng Zhang, Jinlong Yu
Publikováno v: Physiological Reports
Pulmonary complications are common in both AIDS patients and cocaine users. We addressed the cellular and molecular mechanisms by which HIV and cocaine may partner to induce their deleterious effects. Using primary lung lymphatic endothelial cells (L
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd0b1a3d0a4be78c0496d8a014b916fe
https://doi.org/10.14814/phy2.12482
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9
P2 receptor antagonist PPADS confers neuroprotection against glutamate/NMDA toxicity
Autor: Susan Jiang, Angele Desbois, Sheng T. Hou, Yanpeng Lin
Publikováno v: Neuroscience letters. 377(2)
The present study investigated the role of pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid tetrasodium salt (PPADS), a P2 receptor antagonist, in protecting mouse cerebellar granule neurons (CGNs) against glutamate/NMDA-induced neuronal death.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::386a32b1755ab45ff86a02a312374fd2
https://pubmed.ncbi.nlm.nih.gov/15740844
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10
Group B vitamins protect murine cerebellar granule cells from glutamate/NMDA toxicity
Autor: Susan Jiang, Angele Desbois, Yanpeng Lin, Sheng T. Hou
Publikováno v: Neuroreport. 15(14)
The role of B group vitamins in preventing neuronal death against excitotoxicity was investigated. Neuronal death of cultured mouse cerebellar granule neurons (CGNs) caused by glutamate (50 microM) or NMDA (200 microM) was delayed in CGNs that had be
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e54a76a0df2762eb17a3d4ada34fd330
https://pubmed.ncbi.nlm.nih.gov/15371742
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