Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Susan Jean Ward"'
Autor:
Dean A. Haycock, Michael Eissenstat, Joan E. Kuster, Daniel Luttinger, Frances M. Casiano, Kurt A. Josef, Alexandros Makriyannis, Virendra Kumar, James H. Ackerman, Atmaram D. Khanolkar, Jeffrey Abt, Bacon Edward R, Thomas E. D'Ambra, Renee Arnold, John D. Weaver, Malcolm R. Bell, Susan M. Chippari, Joan I. Stevenson, W. Adam G. Hill, Susan Jean Ward, Philip M. Carabateas
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:17-22
Aminoalkylindoles (AAIs) with potent cannabinoid agonist activity have been synthesized where the aminoalkyl chain is attached to the indole ring via a carbon atom of the cyclic amine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8be4d4fe848aed4d5576b63484012c02
https://doi.org/10.1016/0960-894x(95)00560-g
https://doi.org/10.1016/0960-894x(95)00560-g
Autor:
J. L. Flippen-Anderson, Allyn C. Howlett, Koichiro Yamada, Susan Jean Ward, M. A. Eissenstat, Kenner C. Rice, Johnson Mr
Publikováno v:
Journal of Medicinal Chemistry. 39:1967-1974
A series of (aminoalkyl)indole compounds, naphthalene analogs of pravadoline (1), has been shown to exhibit cannabinoid agonist activities such as antinociception in animals, inhibition of adenylate cyclase in brain membranes, and binding to the cann
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::650fc55168b4a1dadd1333447d64d11a
https://doi.org/10.1021/jm950932r
https://doi.org/10.1021/jm950932r
Autor:
S. M. Chippari, Malcolm R. Bell, Michael D. Alexander, Matthew S. Miller, Susan Jean Ward, Dean A. Haycock, Joan I. Stevenson, D. A. Luttinger, Virendra Kumar, Michael Eissenstat, J. E. Kuster, F. M. Casiano
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:381-386
Indence analogs of pravadoline exhibited antinociceptive activity in several animal models. The inhibition of prostaglandin (PG) synthesis in mouse brain microsomes was diminished in these pravadoline analogs, but they were potent in inhibiting elect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ef22acc3f9ebf6dd78e4b6069f09d1d
https://doi.org/10.1016/0960-894x(95)00040-z
https://doi.org/10.1016/0960-894x(95)00040-z
Autor:
F. M. Casiano, Paul V. Kaplita, David M. Sedlock, Susan Jean Ward, Amanda M. Gillum, Colin J. Barrow, K. C. Appell, D. Haycock, Joseph J. Oleynek
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d41ddb1a5ee5bc494c2df54b2c32f7cb
https://doi.org/10.1002/chin.199441216
https://doi.org/10.1002/chin.199441216
Autor:
F. M. Casiano, J. E. Kuster, Michael Eissenstat, Joan I. Stevenson, Michael D. Alexander, Virendra Kumar, Susan Jean Ward, Malcolm R. Bell, Matthew S. Miller, S. M. Chippari, D. A. Luttinger, Dean A. Haycock
Publikováno v:
ChemInform. 26
Indence analogs of pravadoline exhibited antinociceptive activity in several animal models. The inhibition of prostaglandin (PG) synthesis in mouse brain microsomes was diminished in these pravadoline analogs, but they were potent in inhibiting elect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f81d20cc82d3b8fc75871435d826f2b2
https://doi.org/10.1002/chin.199529204
https://doi.org/10.1002/chin.199529204
Autor:
Allyn C. Howlett, Johnson Mr, M. A. Eissenstat, J. L. Flippen-Anderson, Kenner C. Rice, Koichiro Yamada, Susan Jean Ward
Publikováno v:
ChemInform. 27
A series of (aminoalkyl)indole compounds, naphthalene analogs of pravadoline (1), has been shown to exhibit cannabinoid agonist activities such as antinociception in animals, inhibition of adenylate cyclase in brain membranes, and binding to the cann
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6185d922494e1a695cb63785370b188
https://doi.org/10.1002/chin.199635118
https://doi.org/10.1002/chin.199635118
Autor:
Kurt A. Josef, F. M. Casiano, Estep Kg, Beglin Nc, Baizman Er, Thomas E. D'Ambra, Haycock Da, Eissenstat Ma, Susan Jean Ward, Malcolm R. Bell
Publikováno v:
Journal of Medicinal Chemistry. 35:124-135
Pravadoline (1) is an (aminoalkyl)indole analgesic agent which is an inhibitor of cyclooxygenase and, in contrast to other NSAIDs, inhibits neuronally stimulated contractions in mouse vas deferens (MVD) preparations (IC50 = 0.45 microM). A number of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d569e02f54ea111e4fa6c3064b6c782
https://doi.org/10.1021/jm00079a016
https://doi.org/10.1021/jm00079a016
Autor:
William J. Welsh, Allyn C. Howlett, Joong-Youn Shim, Michael Eissenstat, Susan Jean Ward, Elizabeth R. Collantes, Babu Subramaniam
Publikováno v:
Journal of medicinal chemistry. 41(23)
The present study describes the implementation of comparative molecular field analysis (CoMFA) to develop two 3D-QSAR (quantitative structure-activity relationship) models (CoMFA models 1 and 2) of the cannabimimetic (aminoalkyl)indoles (AAIs) for CB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb50805173f588930fdad82757c0e89f
https://pubmed.ncbi.nlm.nih.gov/9804691
https://pubmed.ncbi.nlm.nih.gov/9804691