Responses to high-fat challenges varying in fat type in subjects with different metabolic risk phenotypes: a randomized trial.

Autor: Susan J van Dijk, Marco Mensink, Diederik Esser, Edith J M Feskens, Michael Müller, Lydia A Afman

Publikováno v: PLoS ONE, Vol 7, Iss 7, p e41388 (2012)

The ability of subjects to respond to nutritional challenges can reflect the flexibility of their biological system. Nutritional challenge tests could be used as an indicator of health status but more knowledge on metabolic and immune responses of di

Externí odkaz: https://doaj.org/article/0965c32637b74c50bc9c3bb75873656a

Methylome and transcriptome maps of human visceral and subcutaneous adipocytes reveal key epigenetic differences at developmental genes

Autor: Helen L. Lutgers, Brodie Sutcliffe, Rosanna Arnoldy, Clare Stirzaker, Susan J. van Dijk, Shalima S. Nair, Michael M. Swarbrick, Reginald V. Lord, Firoz Anwar, Peter L. Molloy, Elena Zotenko, Jenny Z. Song, Wenjia Qu, Susan J. Clark, Stephen T Bradford, Denis C. Bauer, Michael Buckley, Michelle Peranec, Hilal Varinli, Katherine Samaras, Aaron L. Statham, Julius Z. H. von Martels, Jason P. Ross, Madhavi P. Maddugoda, Timothy J. Peters, Hugh J. French

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports, 9:9511. Nature Publishing Group
Scientific Reports

Adipocytes support key metabolic and endocrine functions of adipose tissue. Lipid is stored in two major classes of depots, namely visceral adipose (VA) and subcutaneous adipose (SA) depots. Increased visceral adiposity is associated with adverse hea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ab52944b338d30ee88efb302b757c62
https://doi.org/10.1038/s41598-019-45777-w

Angptl4 upregulates cholesterol synthesis in liver via inhibition of LPL- and HL-Dependent hepatic cholesterol uptake

Autor: Patrick C.N. Rensen, Michael Müller, André Bensadoun, Ido P. Kema, Sander Kersten, Laeticia Lichtenstein, Jimmy F.P. Berbée, Susan J. van Dijk, Peter J. Voshol, Ko Willems van Dijk

Publikováno v: Arteriosclerosis Thrombosis and Vascular Biology, 27, 2420-2427
Arteriosclerosis thrombosis and vascular biology, 27(11), 2420-2427. LIPPINCOTT WILLIAMS & WILKINS
Arteriosclerosis Thrombosis and Vascular Biology 27 (2007)

Background— Dysregulation of plasma lipoprotein levels may increase the risk for atherosclerosis. Recently, angiopoietin-like protein 4, also known as fasting-induced adipose factor Fiaf, was uncovered as a novel modulator of plasma lipoprotein met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ebc000a93935ae22dba266200fa0d72
https://doi.org/10.1161/ATVBAHA.107.151894

High fat challenges with different fatty acids affect distinct atherogenic gene expression pathways in immune cells from lean and obese subjects

Autor: Susan J. van Dijk, Michael Müller, Sergio López, Diederik Esser, Lydia A. Afman, Els Oosterink

Publikováno v: Molecular Nutrition & Food Research, 59(8), 1563-1572
Molecular Nutrition & Food Research 59 (2015) 8

Scope - Early perturbations in vascular health can be detected by imposing subjects to a high fat (HF) challenge and measure response capacity. Subtle responses can be determined by assessment of whole-genome transcriptional changes. We aimed to magn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68a8e08463484d0d61711d72a2a522e3
https://research.wur.nl/en/publications/high-fat-challenges-with-different-fatty-acids-affect-distinct-at

A high-fat SFA, MUFA, or n3 PUFA challenge affects the vascular response and initiates an activated state of cellular adherence in lean and obese middle-aged men

Autor: Els Oosterink, Susan J. van Dijk, Diederik Esser, Lydia A. Afman, Michael Müller

Publikováno v: The Journal of Nutrition 143 (2013) 6
The Journal of Nutrition, 143(6), 843-851

BMI and fatty acid type affect postprandial metabolic TG responses, but whether these factors also affect vascular, inflammatory, and leukocyte adherence responses remains unclear. We therefore compared those postprandial responses between lean and o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9377bd00c2bb41098b8e97d53fa878b
https://research.wur.nl/en/publications/a-high-fat-sfa-mufa-or-n3-pufa-challenge-affects-the-vascular-res