Výsledky vyhledávání - "Susan J. G. Loxham"

Reversibility of hyperglycaemia and islet abnormalities in the high fat-fed female ZDF rat model of type 2 diabetes

Autor: Amie C. Gyte, Kimberley C. Young, Susan J. G. Loxham, Rachel M. Mayers, Joanne Teague, Joanne E. Peel, Simon M. Poucher

Publikováno v: Journal of Pharmacological and Toxicological Methods. 63:15-23

Introduction We characterised the development of Type 2 diabetes and associated changes in islet appearance in female ZDF rats and explored its suitability for studies with novel therapeutic agents. Methods Female ZDF rats were either chow or high fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8421447bc9d570da0dda1508a8052e8d
https://doi.org/10.1016/j.vascn.2010.04.001

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An assessment of thein vivoefficacy of the glycogen phosphorylase inhibitor GPi688 in rat models of hyperglycaemia

Autor: Andrew V. Turnbull, J. de Schoolmeester, A D Charles, Frank Carey, Simon M. Poucher, S Berg, G Convey, J B Bartlett, M Walker, Susan J. G. Loxham, S Freeman, Joanne Teague

Publikováno v: British Journal of Pharmacology. 152:1239-1247

Background and purpose: Studies in cultured hepatocytes demonstrate glycogen synthase (GS) activation with glycogen phosphorylase (GP) inhibitors. The current study investigated whether these phenomena occurred in vivo using a novel GP inhibitor. Exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f8bf115215565375edc21b75c902a06a
https://doi.org/10.1038/sj.bjp.0707502

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Discovery of a series of 2-(pyridinyl) pyrimidines as potent antagonists of GPR40

Autor: Alexander G. Dossetter, Helen Pointon, Mark L. Fenwick, Gary Wilkinson, Sam D. Groombridge, David G.A. Morgan, Graeme R. Robb, Susan J. G. Loxham, David Baker, Stuart Norman Lile Bennett, Michael J. Waring, Jenny Morrell, Rob Garcia, Philip A. MacFaul, Jennie Georgsson, David M. Smith, Katie G. Maskill, Stephen Stokes

A series of 2-(pyridinyl)pyrimidines were identified as potent GPR40 antagonists. Despite significant challenges related to improving the combination of potency and lipophilicity within the series, the compounds were optimised to identify a suitable

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f148b3f7ff76822b87760b13cc1915e2

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Sensitivity of glycogen phosphorylase isoforms to indole site inhibitors is markedly dependent on the activation state of the enzyme

Autor: J M Allen, I Hardern, Susan J. G. Loxham, G Convey, Joanne Teague, S Freeman, A D Charles, Simon M. Poucher, J B Bartlett

Publikováno v: British Journal of Pharmacology. 149:775-785

Background and purpose: Inhibition of hepatic glycogen phosphorylase is a potential treatment for glycaemic control in type 2 diabetes. Selective inhibition of the liver phosphorylase isoform could minimize adverse effects in other tissues. We invest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4743bcbc59252ac6d173a1bc61a0260
https://doi.org/10.1038/sj.bjp.0706925

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Acetyl-CoA provision and the acetyl group deficit at the onset of contraction in ischemic canine skeletal muscle

Autor: Susan J. G. Loxham, Simon M. Poucher, Dumitru Constantin-Teodosiu, Paul A. Roberts, Paul L. Greenhaff

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 288:E327-E334

We examined the effects of increasing acetylcarnitine and acetyl-CoA availability at rest, independent of pyruvate dehydrogenase complex (PDC) activation, on energy production and tension development during the rest-to-work transition in canine skele

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a09654ea3edf640f827d942e5222bbd8
https://doi.org/10.1152/ajpendo.00441.2003

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The intravenous glucose tolerance test in cannulated Wistar rats: a robust method for the in vivo assessment of glucose-stimulated insulin secretion

Autor: Simon M. Poucher, Amie C. Gyte, Susan J. G. Loxham, Georgia Frangioudakis

Publikováno v: Journal of pharmacological and toxicological methods. 57(2)

Introduction Glucose-stimulated insulin secretion (GSIS) is critical in mammalian fuel homeostasis and is diminished early in the evolution of β-cell dysfunction, ultimately contributing to the development of Type 2 diabetes. We sought to standardis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50a9e4be80471d7e20e6b6ba932b7766
https://pubmed.ncbi.nlm.nih.gov/18280184

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Glucagon challenge in the rat: a robust method for the in vivo assessment of Glycogen phosphorlyase inhibitor efficacy

Autor: Frank Carey, Susan J. G. Loxham, Joanne De Schoolmeester, Joanne Teague, Simon M. Poucher, Andrew V. Turnbull

Publikováno v: Journal of pharmacological and toxicological methods. 55(1)

Glycogen phosphorlyase inhibitors (GPi) act on the glycogenolytic pathway decreasing hepatic glucose output, making them potential candidates for Type 2 diabetes treatment. We established a robust in vivo method to assess GPis efficacy utilising gluc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f119a9578fc93bf02aa9df3a7a2756b
https://pubmed.ncbi.nlm.nih.gov/16713718

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Bicarbonate-induced alkalosis augments cellular acetyl group availability and isometric force during the rest-to-work transition in canine skeletal muscle

Autor: Paul L. Greenhaff, Simon M. Poucher, Paul Roberts, Dumitru Constantin-Teodosiu, Susan J. G. Loxham

Publikováno v: Experimental physiology. 87(4)

Increasing blood bicarbonate content has long been cited as a potential mechanism to improve contractile function. We investigated whether sodium bicarbonate-induced metabolic alkalosis could positively affect force development during the rest-to-wor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0408141929bf8b4dbaf6f95b966beff3
https://pubmed.ncbi.nlm.nih.gov/12392113

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The acetyl group deficit at the onset of contraction in ischaemic canine skeletal muscle

Autor: Paul Roberts, Paul L. Greenhaff, Dumitru Constantin-Teodosiu, Simon M. Poucher, Susan J. G. Loxham

Publikováno v: The Journal of physiology. 544(2)

Considerable debate surrounds the identity of the precise cellular site(s) of inertia that limit the contribution of mitochondrial ATP resynthesis towards a step increase in workload at the onset of muscular contraction. By detailing the relationship

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90216c89be874e4c6c1b40bb0da42e3a
https://pubmed.ncbi.nlm.nih.gov/12381829

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