Zobrazeno 1 - 10
of 182
pro vyhledávání: '"Susan J Kimber"'
Autor:
Philip A Lewis, Edina Silajdžić, Helen Smith, Nicola Bates, Christopher A Smith, Fabrizio E Mancini, David Knight, Chris Denning, Daniel R Brison, Susan J Kimber
Publikováno v:
PLoS ONE, Vol 19, Iss 6, p e0299365 (2024)
With a view to developing a much-needed non-invasive method for monitoring the healthy pluripotent state of human stem cells in culture, we undertook proteomic analysis of the waste medium from cultured embryonic (Man-13) and induced (Rebl.PAT) human
Externí odkaz:
https://doaj.org/article/ab5be9b6d876451482c5833fcfe03b9d
Autor:
Christopher A Smith, Paul A Humphreys, Mark A Naven, Steven Woods, Fabrizio E Mancini, Julieta O'Flaherty, Qing-Jun Meng, Susan J Kimber
Publikováno v:
PLoS ONE, Vol 18, Iss 1, p e0280024 (2023)
Developmentally, the articular joints are derived from lateral plate (LP) mesoderm. However, no study has produced both LP derived prechondrocytes and preosteoblasts from human pluripotent stem cells (hPSC) through a common progenitor in a chemically
Externí odkaz:
https://doaj.org/article/d854047a6a744d6695132c3159eb8e28
Autor:
Mychel RPT Morais, Pinyuan Tian, Craig Lawless, Syed Murtuza-Baker, Louise Hopkinson, Steven Woods, Aleksandr Mironov, David A Long, Daniel P Gale, Telma MT Zorn, Susan J Kimber, Roy Zent, Rachel Lennon
Publikováno v:
eLife, Vol 11 (2022)
Basement membranes (BMs) are complex macromolecular networks underlying all continuous layers of cells. Essential components include collagen IV and laminins, which are affected by human genetic variants leading to a range of debilitating conditions
Externí odkaz:
https://doaj.org/article/ca2c8946ee08447ca34fde80038066e9
Autor:
Katherine A Wood, Charlie F Rowlands, Huw B Thomas, Steven Woods, Julieta O'Flaherty, Sofia Douzgou, Susan J Kimber, William G Newman, Raymond T O'Keefe
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0233582 (2020)
The craniofacial developmental disorder Burn-McKeown Syndrome (BMKS) is caused by biallelic variants in the pre-messenger RNA splicing factor gene TXNL4A/DIB1. The majority of affected individuals with BMKS have a 34 base pair deletion in the promote
Externí odkaz:
https://doaj.org/article/c678571fe6ac444081dd9b958bc2912b
Autor:
Stéphane C Berneau, Peter T Ruane, Daniel R Brison, Susan J Kimber, Melissa Westwood, John D Aplin
Publikováno v:
Cells, Vol 8, Iss 5, p 432 (2019)
At the onset of pregnancy, embryo implantation is initiated by interactions between the endometrial epithelium and the outer trophectoderm cells of the blastocyst. Osteopontin (OPN) is expressed in the endometrium and is implicated in attachment and
Externí odkaz:
https://doaj.org/article/089f6d7b97634a63b4785fc7e9939468
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64192 (2013)
Early development in humans is characterised by low and variable embryonic viability, reflected in low fecundity and high rates of miscarriage, relative to other mammals. Data from assisted reproduction programmes provides additional evidence that th
Externí odkaz:
https://doaj.org/article/0336abdcbf1347368fae00d0127472d7
Autor:
Maria Keramari, Janet Razavi, Karen A Ingman, Christoph Patsch, Frank Edenhofer, Christopher M Ward, Susan J Kimber
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e13952 (2010)
In preimplantation mammalian development the transcription factor Sox2 (SRY-related HMG-box gene 2) forms a complex with Oct4 and functions in maintenance of self-renewal of the pluripotent inner cell mass (ICM). Previously it was shown that Sox2-/-
Externí odkaz:
https://doaj.org/article/ba393582a3b8418ab6ff01fb5722071a
Publikováno v:
Matrix Biology. 114:18-34
The ADAMTS superfamily is composed of secreted metalloproteases and structurally related non-catalytic ADAMTS-like proteins. A subset of this superfamily, including ADAMTS6, ADAMTS10 and ADAMTSL2, are involved in elastic fiber assembly and bind to fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46fa0b1a005fe9d14fd37ff66f58f8c8
https://doi.org/10.1016/j.matbio.2022.11.001
https://doi.org/10.1016/j.matbio.2022.11.001
Developmental principles informing human pluripotent stem cell differentiation to cartilage and bone
Autor:
Paul A, Humphreys, Fabrizio E, Mancini, Miguel J S, Ferreira, Steven, Woods, Leona, Ogene, Susan J, Kimber
Publikováno v:
Seminars in Cell & Developmental Biology. 127:17-36
Human pluripotent stem cells can differentiate into any cell type given appropriate signals and hence have been used to research early human development of many tissues and diseases. Here, we review the major biological factors that regulate cartilag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f15fedc719c5193bb5dbd90602f0dd
https://doi.org/10.1016/j.semcdb.2021.11.024
https://doi.org/10.1016/j.semcdb.2021.11.024
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is the most common genetic small vessel disease caused by variants in theNOTCH3gene. Patients with CADASIL experience recurrent strokes, developing i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::709262939fa5ed98387cf06e137e3e24
https://doi.org/10.1101/2023.04.26.538393
https://doi.org/10.1101/2023.04.26.538393
