Zobrazeno 1 - 10
of 257
pro vyhledávání: '"Susan J Kimber"'
Autor:
Fabrizio E. Mancini, Paul E. A. Humphreys, Steven Woods, Nicola Bates, Sara Cuvertino, Julieta O’Flaherty, Leela Biant, Marco A. N. Domingos, Susan J. Kimber
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Osteoarthritis is the most common degenerative joint condition, leading to articular cartilage (AC) degradation, chronic pain and immobility. The lack of appropriate therapies that provide tissue restoration combined with the limited lifespa
Externí odkaz:
https://doaj.org/article/7f0785f7ef8b40a899ff7fca232187f7
Autor:
Philip A Lewis, Edina Silajdžić, Helen Smith, Nicola Bates, Christopher A Smith, Fabrizio E Mancini, David Knight, Chris Denning, Daniel R Brison, Susan J Kimber
Publikováno v:
PLoS ONE, Vol 19, Iss 6, p e0299365 (2024)
With a view to developing a much-needed non-invasive method for monitoring the healthy pluripotent state of human stem cells in culture, we undertook proteomic analysis of the waste medium from cultured embryonic (Man-13) and induced (Rebl.PAT) human
Externí odkaz:
https://doaj.org/article/ab5be9b6d876451482c5833fcfe03b9d
Autor:
Paul E.A. Humphreys, Steven Woods, Nicola Bates, Kirsty M. Rooney, Fabrizio E. Mancini, Cerys Barclay, Julieta O’Flaherty, Franck P. Martial, Marco A.N. Domingos, Susan J. Kimber
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113502- (2023)
Summary: Optogenetics is a rapidly advancing technology combining photochemical, optical, and synthetic biology to control cellular behavior. Together, sensitive light-responsive optogenetic tools and human pluripotent stem cell differentiation model
Externí odkaz:
https://doaj.org/article/48364f8484364e76b3439618b536e1c7
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
IntroductionCerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is the most common genetic small vessel disease caused by variants in the NOTCH3 gene. Patients with CADASIL experience recurrent strokes
Externí odkaz:
https://doaj.org/article/41ebd091ac4e40059806aa8527dd856e
Autor:
Sophia A. Read, Chee Shuen Go, Miguel J. S. Ferreira, Cosimo Ligorio, Susan J. Kimber, Ahu G. Dumanli, Marco A. N. Domingos
Publikováno v:
Pharmaceutics, Vol 15, Iss 10, p 2432 (2023)
Naturally derived polysaccharide-based hydrogels, such as alginate, are frequently used in the design of bioinks for 3D bioprinting. Traditionally, the formulation of such bioinks requires the use of pre-reticulated materials with low viscosities, wh
Externí odkaz:
https://doaj.org/article/6a3d9f6f625546cf9c176b335ba2965e
Autor:
Christopher A Smith, Paul A Humphreys, Mark A Naven, Steven Woods, Fabrizio E Mancini, Julieta O'Flaherty, Qing-Jun Meng, Susan J Kimber
Publikováno v:
PLoS ONE, Vol 18, Iss 1, p e0280024 (2023)
Developmentally, the articular joints are derived from lateral plate (LP) mesoderm. However, no study has produced both LP derived prechondrocytes and preosteoblasts from human pluripotent stem cells (hPSC) through a common progenitor in a chemically
Externí odkaz:
https://doaj.org/article/d854047a6a744d6695132c3159eb8e28
Publikováno v:
Stem Cell Research, Vol 64, Iss , Pp 102880- (2022)
TYR encodes tyrosinase, the enzyme catalysing the first steps of melanin biosynthesis in melanocytes and retinal pigment epithelia (RPE). The TYR c.575C>A (p.Ser192Tyr) [rs1042602] and c.1205G>A (p.Arg402Gln) [rs1126809] variants are prevalent geneti
Externí odkaz:
https://doaj.org/article/d9e5a9e37e6a4cebbb6e069ecb73cb40
Autor:
Claire Hopton, Anke J. Tijsen, Leonid Maizels, Gil Arbel, Amira Gepstein, Nicola Bates, Benjamin Brown, Irit Huber, Susan J. Kimber, William G. Newman, Luigi Venetucci, Lior Gepstein
Publikováno v:
Physiological Reports, Vol 10, Iss 8, Pp n/a-n/a (2022)
Abstract Heterozygous missense variants of the cardiac ryanodine receptor gene (RYR2) cause catecholaminergic polymorphic ventricular tachycardia (CPVT). These missense variants of RYR2 result in a gain of function of the ryanodine receptors, charact
Externí odkaz:
https://doaj.org/article/0a54c9a572d34f8e990a65b6a055122d
Autor:
Mychel RPT Morais, Pinyuan Tian, Craig Lawless, Syed Murtuza-Baker, Louise Hopkinson, Steven Woods, Aleksandr Mironov, David A Long, Daniel P Gale, Telma MT Zorn, Susan J Kimber, Roy Zent, Rachel Lennon
Publikováno v:
eLife, Vol 11 (2022)
Basement membranes (BMs) are complex macromolecular networks underlying all continuous layers of cells. Essential components include collagen IV and laminins, which are affected by human genetic variants leading to a range of debilitating conditions
Externí odkaz:
https://doaj.org/article/ca2c8946ee08447ca34fde80038066e9
Autor:
Joseph Kelleher, Adam Dickinson, Stuart Cain, Yanhua Hu, Nicola Bates, Adam Harvey, Jianzhen Ren, Wenjun Zhang, Fiona C. Moreton, Keith W. Muir, Christopher Ward, Rhian M. Touyz, Pankaj Sharma, Qingbo Xu, Susan J. Kimber, Tao Wang
Publikováno v:
Stem Cell Reports, Vol 13, Iss 5, Pp 817-831 (2019)
Summary: CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is the most common form of genetic stroke and vascular dementia syndrome resulting from mutations in NOTCH3. To elucidate molecular mechanis
Externí odkaz:
https://doaj.org/article/5f1aead6558d4738a4ebf3c5651b3e21