Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Susan J Burke"'
Publikováno v:
Pharmacological Research, Vol 208, Iss , Pp 107342- (2024)
Recent advancements in immunology and islet biology have unveiled remarkable prospects for the postponement of Type 1 diabetes (T1D) through the strategic modulation of the immune system. In this Perspective, we discuss the pharmaceutical strides ach
Externí odkaz:
https://doaj.org/article/c648dcf52bcb443daacf2a779655f860
Autor:
Susan J Burke, Matthew R Goff, Barrett L Updegraff, Danhong Lu, Patricia L Brown, Steven C Minkin, John P Biggerstaff, Ling Zhao, Michael D Karlstad, J Jason Collier
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46986 (2012)
Release of pro-inflammatory cytokines from both resident and invading leukocytes within the pancreatic islets impacts the development of Type 1 diabetes mellitus. Synthesis and secretion of the chemokine CCL2 from pancreatic β-cells in response to p
Externí odkaz:
https://doaj.org/article/3839705fe886483eaf685812f46362f4
Autor:
J Jason Collier, Susan J Burke, Mary E Eisenhauer, Danhong Lu, Renee C Sapp, Carlie J Frydman, Shawn R Campagna
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22485 (2011)
A reduction in functional β-cell mass leads to both major forms of diabetes; pro-inflammatory cytokines, such as interleukin-1beta (IL-1β) and gamma-interferon (γ-IFN), activate signaling pathways that direct pancreatic β-cell death and dysfuncti
Externí odkaz:
https://doaj.org/article/b5e94ad1d4c7433d839020e8c4d46ae2
Autor:
Wesley B. Seaton, Susan J. Burke, Alexander R. Fisch, William A. Schilletter, Mary Grace A. Beck, Gabrielle A. Cassagne, Innocence Harvey, Molly S. Fontenot, J. Jason Collier, Shawn R. Campagna
Publikováno v:
Molecules, Vol 29, Iss 7, p 1546 (2024)
Glucocorticoids (GCs) act through the glucocorticoid receptor (GR) and are commonly used as anti-inflammatory and immunosuppressant medications. Chronic GC use has been linked with unwanted complications such as steroid-induced diabetes mellitus (SID
Externí odkaz:
https://doaj.org/article/d0cba9308f9f4278a98aa152b0d66e4a
Autor:
Melissa A. Linden, Susan J. Burke, Humza A. Pirzadah, Tai-Yu Huang, Heidi M. Batdorf, Walid K. Mohammed, Katarina A. Jones, Sujoy Ghosh, Shawn R. Campagna, J. Jason Collier, Robert C. Noland
Publikováno v:
Molecular Metabolism, Vol 74, Iss , Pp 101751- (2023)
Objective: Glucocorticoids are one of the most commonly prescribed classes of anti-inflammatory drugs; however, chronic treatment promotes iatrogenic (drug-induced) diabetes. As part of their physiological role, glucocorticoids stimulate lipolysis to
Externí odkaz:
https://doaj.org/article/67d2a26f8970404fb0fe593b4ffab107
Autor:
Cristal M. Hill, Diana C. Albarado, Lucia G. Coco, Redin A. Spann, Md Shahjalal Khan, Emily Qualls-Creekmore, David H. Burk, Susan J. Burke, J. Jason Collier, Sangho Yu, David H. McDougal, Hans-Rudolf Berthoud, Heike Münzberg, Andrzej Bartke, Christopher D. Morrison
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
The restriction of dietary protein or amino acid intake is well established to extend lifespan in multiple species. Here, the authors show that the endocrine hormone FGF21 is necessary for dietary protein restriction to extend lifespan and improve me
Externí odkaz:
https://doaj.org/article/4650d44069f84d4b904fb8abe5136b6d
Autor:
Allison McCrimmon, Kerin M. Cahill, Claudia Kruger, Margaret E. Mangelli, Emily Bouffard, Timothy Dobroski, Kelly N. Michanczyk, Susan J. Burke, Robert C. Noland, Daria V. Ilatovskaya, Krisztian Stadler
Publikováno v:
JCI Insight, Vol 7, Iss 7 (2022)
The importance of healthy mitochondrial function is implicated in the prevention of chronic kidney disease (CKD) and diabetic kidney disease (DKD). Sex differences also play important roles in DKD. Our previous studies revealed that mitochondrial sub
Externí odkaz:
https://doaj.org/article/e2721d6acb4b423b88604d734887d262
Autor:
Jennifer L. Bailey, David H. Burk, Susan J. Burke, Scott D. Reed, Sujoy Ghosh, Carrie M. Elks
Publikováno v:
Biomedicines, Vol 10, Iss 9, p 2077 (2022)
Laminins are heterotrimeric glycoproteins with structural and functional roles in basement membranes. The predominant laminin alpha chain found in adipocyte basement membranes is laminin α4 (LAMA4). Global LAMA4 deletion in mice leads to reduced adi
Externí odkaz:
https://doaj.org/article/b1ed2e85be37421d8cf0b9454fd65f2c
Autor:
J. Jason Collier, Susan J. Burke
Publikováno v:
Biomedicines, Vol 10, Iss 7, p 1471 (2022)
This Biomedicines Special Issue was designed to attract articles that focused on different facets of biology relating to insulin resistance, defined as reduced cellular and organismal response to the insulin hormone, and its underlying mechanisms [..
Externí odkaz:
https://doaj.org/article/5eb780e974f448a39a4ee2428f051ab5
Autor:
J. Jason Collier, Heidi M. Batdorf, Thomas M. Martin, Kristen E. Rohli, David H. Burk, Danhong Lu, Chris R. Cooley, Michael D. Karlstad, Joseph W. Jackson, Tim E. Sparer, Jingying Zhang, Randall L. Mynatt, Susan J. Burke
Publikováno v:
Molecular Metabolism, Vol 44, Iss , Pp 101140- (2021)
Objective: The expression of the interleukin-1 receptor type I (IL-1R) is enriched in pancreatic islet β-cells, signifying that ligands activating this pathway are important for the health and function of the insulin-secreting cell. Using isolated m
Externí odkaz:
https://doaj.org/article/1a3edd9950484f2c84401d8bd197de64