Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Susan J, Tudhope"'
Autor:
Lan Z. Wang, Miller Duncan Charles, Bernard T. Golding, Ian Hickson, Martin E.M. Noble, Celine Cano, Suzannah J. Harnor, Michael J. Waring, Harry J Shrives, Shaimaa Khalifa, Jane Totobenazara, Stephen J. Hobson, Elaine Willmore, Hannah L Stewart, Mathew P. Martin, Susan J. Tudhope, Huw D. Thomas, Islam Al-Khawaldeh, Claire E. Jennings, João V de Souza, Max J. Temple, Jane A. Endicott, Cinzia Bordoni, Honorine Lebraud, Agnieszka K. Bronowska, Ian R. Hardcastle, Amy B. Heptinstall, Stephen R. Wedge, Christine Basmadjian, Gregory G Aldred, Julie A. Tucker, Mohammed J Al Yasiri
Publikováno v:
Journal of Medicinal Chemistry. 64:10001-10018
NF-κB-inducing kinase (NIK) is a key enzyme in the noncanonical NF-κB pathway, of interest in the treatment of a variety of diseases including cancer. Validation of NIK as a drug target requires potent and selective inhibitors. The protein contains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56300566066f33b5e78d20a96b537040
https://doi.org/10.1021/acs.jmedchem.0c01249
https://doi.org/10.1021/acs.jmedchem.0c01249
Regulation of p53 and Rb links the alternative NF-κB pathway to EZH2 expression and cell senescence.
Autor:
Alessio Iannetti, Adeline C Ledoux, Susan J Tudhope, Hélène Sellier, Bo Zhao, Sophia Mowla, Adam Moore, Holger Hummerich, Benjamin E Gewurz, Simon J Cockell, Parmjit S Jat, Elaine Willmore, Neil D Perkins
Publikováno v:
PLoS Genetics, Vol 10, Iss 9, p e1004642 (2014)
There are two major pathways leading to induction of NF-κB subunits. The classical (or canonical) pathway typically leads to the induction of RelA or c-Rel containing complexes, and involves the degradation of IκBα in a manner dependent on IκB ki
Externí odkaz:
https://doaj.org/article/aaddeaccf33b4b40bce0cfbdad0a4454
Autor:
Fadhel M. Lafta, Laura Woodhouse, Gordon Strathdee, Helen Marr, Scott Marshall, Elaine Willmore, Timothy M. Barrow, Susan J. Tudhope, Kateryna Bilotkach, Nick Bown, Jonathan P. Wallis, Sirintra Nakjang, Gesa Junge
Publikováno v:
British Journal of Cancer
Background Chronic lymphocytic leukaemia (CLL) patients display a highly variable clinical course, with progressive acquisition of drug resistance. We sought to identify aberrant epigenetic traits that are enriched following exposure to treatment tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f87eb3bbb057e5a9ebd0c2ce8c9643
http://sure.sunderland.ac.uk/id/eprint/12635/1/Barrow_BrJCancer_combined_final.pdf
http://sure.sunderland.ac.uk/id/eprint/12635/1/Barrow_BrJCancer_combined_final.pdf
Autor:
Ziad H. Al-Oanzi, Sophia Fountana, Ahmed Alshawi, Loranne Agius, John L. Petrie, Susan J. Tudhope, G.L. Patman, Catherine Arden, Tabassum Moonira, Helen L. Reeves
Publikováno v:
Diabetes, Obesity and Metabolism. 19:1078-1087
Aim Small molecule activators of glucokinase (GKAs) have been explored extensively as potential anti-hyperglycaemic drugs for type 2 diabetes (T2D). Several GKAs were remarkably effective in lowering blood glucose during early therapy but then lost t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a86c23beda7aa723b50186a21c319555
https://doi.org/10.1111/dom.12910
https://doi.org/10.1111/dom.12910
Autor:
Benoit Carbain, E. Anscombe, Jane A. Endicott, Christopher R. Coxon, Mathew P. Martin, Stephen R. Wedge, Christopher Wong, Svitlana Korolchuk, Mangaleswaran Sivaprakasam, Bernard T. Golding, Lisa K. Harlow, Celine Cano, Suzannah J. Harnor, Christopher J. Matheson, Lan Z. Wang, David M. Turner, Martin E.M. Noble, David R. Newell, Ian R. Hardcastle, Roger J. Griffin, Susan J. Tudhope
Publikováno v:
Journal of Medicinal Chemistry
Purines and related heterocycles substituted at C-2 with 4’-sulfamoylanilino and at C-6 with a variety of groups have been synthesized with the aim of achieving selectivity of binding to CDK2 over CDK1. 6-Substituents that favour competitive inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e79c5e8c85af8caa2cdd1125fa18b4b
http://europepmc.org/articles/PMC6111440
http://europepmc.org/articles/PMC6111440
Autor:
Huw D. Thomas, Celine Cano, Anderson J. Ryan, M. Raymond V. Finlay, Yanyan Jiang, Yan Zhao, Helen L. Reeves, Nicole Phillips, Luiza Madia Lourenco, Catherine E. Willoughby, Gesa Junge, David R. Newell, Joanne M. Munck, Anita Wittner, Lisa Prendergast, Roger J. Griffin, Stephen R. Wedge, Tommy Rennison, Suzanne Kyle, Turner Paul, Elaine Willmore, Susan J. Tudhope, James Pickles
Publikováno v:
The Journal of Clinical Investigation
Potentiating radiotherapy and chemotherapy by inhibiting DNA damage repair is proposed as a therapeutic strategy to improve outcomes for patients with solid tumors. However, this approach risks enhancing normal tissue toxicity as much as tumor toxici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcfec92227f655feda3619c7b6de2be2
Autor:
Ziad H, Al-Oanzi, Sophia, Fountana, Tabassum, Moonira, Susan J, Tudhope, John L, Petrie, Ahmed, Alshawi, Gillian, Patman, Catherine, Arden, Helen L, Reeves, Loranne, Agius
Publikováno v:
Diabetes, obesitymetabolism. 19(8)
Small molecule activators of glucokinase (GKAs) have been explored extensively as potential anti-hyperglycaemic drugs for type 2 diabetes (T2D). Several GKAs were remarkably effective in lowering blood glucose during early therapy but then lost their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::103eb2ad4fe767f364a510f7c6c83da3
https://pubmed.ncbi.nlm.nih.gov/28206714
https://pubmed.ncbi.nlm.nih.gov/28206714
Autor:
Kylie B. R. Belchamber, Cláudia Henrique da Costa, Peter J. Barnes, Richard Russell, Suzanne L. Traves, Peter Fenwick, Susan J. Tudhope, Louise E. Donnelly
Publikováno v:
The European respiratory journal. 47(4)
Chronic obstructive pulmonary disease (COPD) patients exhibit chronic inflammation, both in the lung parenchyma and the airways, which is characterised by an increased infiltration of macrophages and T-lymphocytes, particularly CD8+ cells. Both cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdaa2b8a58e904251b8706cad7d6a5d4
https://pubmed.ncbi.nlm.nih.gov/26965295
https://pubmed.ncbi.nlm.nih.gov/26965295
Autor:
Howard C. Towle, Robert J. Beynon, Catherine Arden, John L. Petrie, Susan J. Tudhope, Amy J. Claydon, Loranne Agius, Ziad H. Al-Oanzi
Publikováno v:
Diabetes
OBJECTIVE The induction of hepatic glucose 6-phosphatase (G6pc) by glucose presents a paradox of glucose-induced glucose intolerance. We tested whether glucose regulation of liver gene expression is geared toward intracellular homeostasis. RESEARCH D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf9c5eff04a4348c8480038a18d7f140
http://europepmc.org/articles/PMC3219956
http://europepmc.org/articles/PMC3219956
Autor:
Ursula Straschil, Carol Pridgeon, Louise E. Donnelly, Laurence Bugeon, Peter J. Barnes, Margaret J. Dallman, Susan J. Tudhope, Jonathan R. Lamb, Peter Fenwick
Publikováno v:
Clinical Science. 120:515-524
The regulation of human Th17 cell effector function by Treg cells (regulatory T-cells) is poorly understood. In the present study, we report that human Treg (CD4+CD25+) cells inhibit the proliferative response of Th17 cells but not their capacity to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bce4ecf80bb86584a0b476f3e6d0102d
https://doi.org/10.1042/cs20100417
https://doi.org/10.1042/cs20100417