Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Susan J, Johns"'
Autor:
Stephanie E Hesselson, Pär Matsson, James E Shima, Hisayo Fukushima, Sook Wah Yee, Yuya Kobayashi, Jason M Gow, Connie Ha, Benjamin Ma, Annie Poon, Susan J Johns, Doug Stryke, Richard A Castro, Harunobu Tahara, Ji Ha Choi, Ligong Chen, Nicolas Picard, Elin Sjödin, Maarke J E Roelofs, Thomas E Ferrin, Richard Myers, Deanna L Kroetz, Pui-Yan Kwok, Kathleen M Giacomini
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e6942 (2009)
Membrane transporters play crucial roles in the cellular uptake and efflux of an array of small molecules including nutrients, environmental toxins, and many clinically used drugs. We hypothesized that common genetic variation in the proximal promote
Externí odkaz:
https://doaj.org/article/09fb7e921026438cb6a8f93630163930
Autor:
Lu Xu, Doug Stryke, Eugene C. Chen, Xin Chen, Kathleen M. Giacomini, Jeff Simko, Sook Wah Yee, Susan J. Johns, Kacyn Fujii, Joseph F. Costello, Emil U. Almof, Wen Cc, Thomas E. Ferrin, Chibo Hong, Ligong Chen
Publikováno v:
The pharmacogenomics journal
Human organic cation transporter 3 (OCT3 and SLC22A3) mediates the uptake of many important endogenous amines and basic drugs in a variety of tissues. OCT3 is identified as one of the important risk loci for prostate cancer, and is markedly underexpr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95ff6a2f9aa1da3dd20f480848f3d929
https://doi.org/10.1038/tpj.2011.60
https://doi.org/10.1038/tpj.2011.60
Autor:
Sook Wah Yee, Peter Skewes-Cox, Nadav Ahituv, Stephanie Hesselson, Hisayo Fukushima, Loan Nguyen, Jasmin L Eshragh, Susan J. Johns, Mee J. Kim, Laura B. Ramsey, Kathleen M. Giacomini, Thomas E. Ferrin, Mary V. Relling, Deanna L. Kroetz, Douglas Stryke, Pui-Yan Kwok, Richard A. Castro, Wen Cc
Publikováno v:
Clinical Pharmacology & Therapeutics. 89:571-578
Little is known about how genetic variations in enhancers influence drug response. In this study, we investigated whether nucleotide variations in enhancers that regulate drug transporters can alter their expression levels. Using comparative genomics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31effd3cc703a9168001a9504ea2606a
https://doi.org/10.1038/clpt.2010.353
https://doi.org/10.1038/clpt.2010.353
Autor:
Kathleen M. Giacomini, Min Goo Lee, Doug Stryke, Stephanie Hesselson, Jeong Ho Lee, Richard A. Castro, Thomas E. Ferrin, Brain L. Black, Loan Nguyen, Susan J. Johns, Sook Wah Yee, Nadav Ahituv, Mee J. Kim, Ji Ha Choi, Ji One Kang, Pui-Yan Kwok
Publikováno v:
Pharmacogenetics and Genomics. 19:770-780
Objectives Human multidrug and toxin extrusion member 1, MATE1 (SLC47A1), plays an important role in the renal and biliary excretion of endogenous and exogenous organic cations including many therapeutic drugs. In this study, we characterized the tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bee7b1e19709dfebdb54c0e5e6fe2db
https://doi.org/10.1097/fpc.0b013e328330eeca
https://doi.org/10.1097/fpc.0b013e328330eeca
Autor:
Sook Wah Yee, Stephanie Hesselson, Susan J. Johns, Pui-Yan Kwok, Richard A. Castro, Harunobu Tahara, Doug Stryke, Thomas E. Ferrin, Michiko Kawamoto, Thomas J. Urban, Kathleen M. Giacomini
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 329:262-271
The organic cation/ergothioneine transporter OCTN1 (SLC22A4) and the high-affinity carnitine transporter OCTN2 (SLC22A5), play an important role in the disposition of xenobiotics and endogenous compounds. Here, we analyzed the sequence of the proxima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb9f6632c4bb1cf4784b8561f867b39
https://doi.org/10.1124/jpet.108.146449
https://doi.org/10.1124/jpet.108.146449
Autor:
Thomas J, Urban, Chen, Yang, Leah L, Lagpacan, Chaline, Brown, Richard A, Castro, Travis R, Taylor, Conrad C, Huang, Douglas, Stryke, Susan J, Johns, Michiko, Kawamoto, Elaine J, Carlson, Thomas E, Ferrin, Esteban G, Burchard, Kathleen M, Giacomini
Publikováno v:
Pharmacogenetics and Genomics. 17:773-782
OCTN1 is a multispecific transporter of organic cations and zwitterions, including several clinically important drugs as well as the antioxidant ergothioneine. OCTN1 is highly expressed in the kidney, where it is thought to aid in active secretion of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::669427edd0777d7a27cbc72a63f6739d
https://doi.org/10.1097/fpc.0b013e3281c6d08e.
https://doi.org/10.1097/fpc.0b013e3281c6d08e.
Interaction of Methotrexate with Organic-Anion Transporting Polypeptide 1A2 and Its Genetic Variants
Autor:
Ilaria Badagnani, Esteban G. Burchard, Travis R. Taylor, Michiko Kawamoto, Richard A. Castro, Elaine J. Carlson, Douglas Stryke, Conrad C. Huang, Kathleen M. Giacomini, Claire M. Brett, Susan J. Johns, Thomas E. Ferrin
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 318:521-529
Methotrexate (MTX) is used in patients with malignant and autoimmune diseases. This drug is primarily excreted unchanged in the urine, and its net excretion occurs via active secretory and reabsorptive processes. We characterized the interaction of M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41a9362690684d3e660625c6f46a8fe0
https://doi.org/10.1124/jpet.106.104364
https://doi.org/10.1124/jpet.106.104364
Autor:
Melanie De La Cruz, Esteban G. Burchard, Leah L. Lagpacan, Kathleen M. Giacomini, Elaine J. Carlson, Douglas Stryke, Travis R. Taylor, Claire M. Brett, Conrad C. Huang, Thomas J. Urban, Thomas E. Ferrin, Lara M. Mangravite, Susan J. Johns, Michiko Kawamoto, Andrew R. Erdman, Richard A. Castro, Wendy Chan
Publikováno v:
American Journal of Physiology-Renal Physiology. 290:F905-F912
The human organic anion transporter, OAT3 ( SLC22A8), plays a critical role in renal drug elimination, by mediating the entry of a wide variety of organic anions, including a number of commonly used pharmaceuticals, into the renal proximal tubular ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9ce746a38b55d7cf3a0f5fe68b0bdab
https://doi.org/10.1152/ajprenal.00272.2005
https://doi.org/10.1152/ajprenal.00272.2005
Autor:
Susan J. Johns, Thomas E. Ferrin, Douglas Stryke, Esteban G. Burchard, Michiko Kawamoto, Richard A. Castro, Wendy Chan, Elaine J. Carlson, Conrad C. Huang, Kathleen M. Giacomini, Claire M. Brett, Ilaria Badagnani
Publikováno v:
The Pharmacogenomics Journal. 5:157-165
The human concentrative nucleoside transporter, CNT3 (SLC28A3), plays an important role in mediating the cellular entry of a broad array of physiological nucleosides and synthetic anticancer nucleoside analog drugs. As a first step toward understandi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a57439ddafb72109ddd5dc3e4858ada
https://doi.org/10.1038/sj.tpj.6500303
https://doi.org/10.1038/sj.tpj.6500303
Autor:
Conrad C. Huang, Doug Stryke, Susan J. Johns, Jennifer H. Gray, Ryan P. Owen, Kathleen M. Giacomini, Travis R. Taylor, Elaine J. Carlson, Michiko Kawamoto, Thomas E. Ferrin
Publikováno v:
Pharmacogenetics and Genomics. 15:83-90
The concentrative nucleoside transporter CNT2 (SPNT1; SLC28A2) plays a role in the absorption and disposition of naturally occurring nucleosides, as well as nucleoside analog drugs. The aim of the present study was to characterize genetic variation i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f2b25a730f4f4d3e6c3cffe8cf4ca3b
https://doi.org/10.1097/01213011-200502000-00004
https://doi.org/10.1097/01213011-200502000-00004