Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Susan J, Henning"'
Autor:
Richard J. von Furstenberg, Joy Li, Christina Stolarchuk, Rachel Feder, Alexa Campbell, Leandi Kruger, Liara M. Gonzalez, Anthony T. Blikslager, Diana M. Cardona, Shannon J. McCall, Susan J. Henning, Katherine S. Garman
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 4, Iss 3, Pp 385-404 (2017)
Background & Aims: Although cells comprising esophageal submucosal glands (ESMGs) represent a potential progenitor cell niche, new models are needed to understand their capacity to proliferate and differentiate. By histologic appearance, ESMGs have b
Externí odkaz:
https://doaj.org/article/9faea1f8eaff4585a42142751bae9f9c
Autor:
Richard J. von Furstenberg, Simon J.A. Buczacki, Brian J. Smith, Kristen M. Seiler, Douglas J. Winton, Susan J. Henning
Publikováno v:
Stem Cell Research, Vol 12, Iss 2, Pp 364-375 (2014)
We report here that side population (SP) sorting allows for the simultaneous isolation of two intestinal stem cell (ISC) subsets from wild-type (WT) mice which are phenotypically different and represent cycling and non-cycling pools of cells. Followi
Externí odkaz:
https://doaj.org/article/a3ad3928bf424772aa8adad1909d74fa
Autor:
Julie M Davies, Rebeca Santaolalla, Richard J von Furstenberg, Susan J Henning, Maria T Abreu
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138531 (2015)
The intestinal epithelium is the first line of defense against enteric pathogens. We investigated the response of small intestinal and colonic crypt cultures to a panel of toll-like receptor ligands to assess the impact of microbial pattern recogniti
Externí odkaz:
https://doaj.org/article/4733e151be434b888cf61e916c89aaa5
Autor:
Laurianne Van Landeghem, Randall Eric Blue, Jeffrey J Dehmer, Susan J Henning, Michael A Helmrath, Pauline Kay Lund
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51310 (2012)
In vivo studies of high dose radiation-induced crypt and intestinal stem cell (ISC) loss and subsequent regeneration are typically restricted to 5-8 days after radiation due to high mortality and immune failure. This study aimed to develop murine rad
Externí odkaz:
https://doaj.org/article/5e6548c6577e473d8c8f47a9bf4ff86a
Autor:
Ajay S Gulati, Michael T Shanahan, Janelle C Arthur, Emily Grossniklaus, Richard J von Furstenberg, Lieselotte Kreuk, Susan J Henning, Christian Jobin, R Balfour Sartor
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32403 (2012)
Increasing evidence supports the central role of Paneth cells in maintaining intestinal host-microbial homeostasis. However, the direct impact of host genotype on Paneth cell function remains unclear. Here, we characterize key differences in Paneth c
Externí odkaz:
https://doaj.org/article/f7b812795bde4fb9a4bfa0d87c634e46
Autor:
Jeffrey J Dehmer, Aaron P Garrison, Karen E Speck, Christopher M Dekaney, Laurianne Van Landeghem, Xiaofei Sun, Susan J Henning, Michael A Helmrath
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27070 (2011)
Murine small intestinal crypt development is initiated during the first postnatal week. Soon after formation, overall increases in the number of crypts occurs through a bifurcating process called crypt fission, which is believed to be driven by devel
Externí odkaz:
https://doaj.org/article/20867ca9147547bdb19675089fa68876
Autor:
Arnold Han, Xiao Li, Solongo B. Ziraldo, Michael Snyder, Aaron J. W. Hsueh, Tarjei S. Mikkelsen, Kathryn A. Larkin, Vincent C. Luca, Julie Wilhelmy, Akifumi Ootani, Heather Ordonez, Luis A. Chia, Kelly Roelf, Mark Lee, Christopher R. Bolen, Junlei Chang, Hiroo Ueno, Calvin J. Kuo, Susan J. Henning, Paige S. Davies, Jessica M. Terry, Kelley S. Yan, Jenny Yuan, Phillip Belgrader, K. Christopher Garcia, Melissa H. Wong, Amanda T. Mah, Irving L. Weissman, Claudia Y. Janda, Grace X.Y. Zheng, Richard J. von Furstenberg
Publikováno v:
Nature. 545:238-242
The canonical Wnt/β-catenin signalling pathway governs diverse developmental, homeostatic and pathological processes. Palmitoylated Wnt ligands engage cell-surface frizzled (FZD) receptors and LRP5 and LRP6 co-receptors, enabling β-catenin nuclear
Publikováno v:
The Journal of Physiology. 594:4769-4779
This overview gives a brief historical summary of key discoveries regarding stem cells of the small intestine. The current concept is that there are two pools of intestinal stem cells (ISCs): an actively cycling pool that is marked by Lgr5, is relati
Autor:
Ajay S. Gulati, Molly Stein, Farah S. Hussain, Richard J. von Furstenberg, Smrithi Valsaraj, Susan J. Henning, Alexi A. Schoenborn, Michael J. Shanahan
Paneth cells (PCs) are epithelial cells found in the small intestine, next to intestinal stem cells (ISCs) at the base of the crypts. PCs secrete antimicrobial peptides (AMPs) that regulate the commensal gut microbiota. In contrast, little is known r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2ab53acec9ddb718c1caf90e24eeca2
https://europepmc.org/articles/PMC6363071/
https://europepmc.org/articles/PMC6363071/
Autor:
Mary K. Estes, Susan J. Henning
Publikováno v:
Gastroenterology. 149:10-13
For those who don’t know us, let us first introduce ourselves. Both of us are basic scientists who have devoted our research careers to GI topics. We are beyond retirement age as defined by Social Security (and not giving more details), but still f