Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Susan I. Vear"'
Autor:
Deipanjan Nandi, Jill Fitch, Jennifer A. Belsky, Joseph Stanek, Nicholas D. Yeager, Susan I. Vear
Publikováno v:
JCO Precision Oncology. :1-4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed42f4891a00f269d19d8a271be440d1
https://doi.org/10.1200/po.18.00333
https://doi.org/10.1200/po.18.00333
Autor:
Sara L Van Driest, Tracy L McGregor, Digna R Velez Edwards, Ben R Saville, Terrie E Kitchner, Scott J Hebbring, Murray Brilliant, Hayan Jouni, Iftikhar J Kullo, C Buddy Creech, Prince J Kannankeril, Susan I Vear, Kyle B Brothers, Erica A Bowton, Christian M Shaffer, Neelam Patel, Jessica T Delaney, Yuki Bradford, Sarah Wilson, Lana M Olson, Dana C Crawford, Amy L Potts, Richard H Ho, Dan M Roden, Josh C Denny
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0127791 (2015)
Vancomycin, a commonly used antibiotic, can be nephrotoxic. Known risk factors such as age, creatinine clearance, vancomycin dose / dosing interval, and concurrent nephrotoxic medications fail to accurately predict nephrotoxicity. To identify potenti
Externí odkaz:
https://doaj.org/article/d1b2a61fcf654975a0b71ba96a9457bc
Publikováno v:
Annual review of pharmacology and toxicology. 60
Pharmacogenetics is a key component of precision medicine. Genetic variation in drug metabolism enzymes can lead to variable exposure to drugs and metabolites, potentially leading to inefficacy and drug toxicity. Although the evidence for pharmacogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d959d6fb77ef9605470d75853755154e
https://pubmed.ncbi.nlm.nih.gov/31283429
https://pubmed.ncbi.nlm.nih.gov/31283429
Autor:
Kunihiko Itoh, Tina T. Biss, Mia Wadelius, Fanny Bajolle, Kaitlyn Shaw, Anna-Karin Hamberg, Masanobu Takeuchi, Takuya Wakamiya, Masakatsu Yanagimachi, Masato Taguchi, Marie-Anne Loriot, Keita Hirai, Leonardo R. Brandão, Bruce Carleton, Richard H. Ho, Susan I. Vear, Shinya Ito, Farhad Kamali, Tohru Kobayashi, Keiichi Hirono
Publikováno v:
The pharmacogenomics journal. 20(2)
Studies on the effect of cytochrome P450 2C9 (CYP2C9), vitamin K epoxide reductase complex subunit 1 (VKORC1), and cytochrome P450 4F2 (CYP4F2) polymorphisms on warfarin maintenance dose in children are conflicting. We conducted a systematic review a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40dc9a487060c36b3e3131f2de8c701d
https://pubmed.ncbi.nlm.nih.gov/31673144
https://pubmed.ncbi.nlm.nih.gov/31673144
Autor:
Margaret E. Macy, Amit J. Sabnis, Katherine A. Janeway, Neal I. Lindeman, Alanna J. Church, Laura Corson, Susan I. Vear, Daniel A. Weiser, Navin R. Pinto, Samuel L. Volchenboum, Julia Glade-Bender, Jaclyn Schienda, Jonathan A. Nowak, Wenjun Kang, Alma Imamovic-Tuco, Joshua D. Schiffman, AeRang Kim, Catherine Clinton, Theodore W. Laetsch, Danielle K. Manning, Brian D. Crompton, Luke Maese, Rochelle Bagatell, Mark A. Applebaum, Junne Kamihara
Publikováno v:
Cancer Research. 80:A06-A06
Introduction: Tumor profiling is becoming a more routine part of clinical care. Many academic centers and commercial entities offer tumor sequencing of cancer-related genes without matched germline profiling. We hypothesize that tumor-only sequencing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62c31d678b1ba308d80b5d8e42d030cb
https://doi.org/10.1158/1538-7445.pedca19-a06
https://doi.org/10.1158/1538-7445.pedca19-a06
Autor:
Wendy B. London, Luke Maese, Katherine A. Janeway, Theodore W. Laetsch, Steven G. DuBois, Neal I. Lindeman, AeRang Kim, Pei-Chi Kao, Duong Doan, Brian D. Crompton, Navin R. Pinto, Suzanne J. Forrest, R. Seth Pinches, Deirdre Reidy, Laura Corson, Lobin A. Lee, Samuel L. Volchenboum, Mark A. Applebaum, Alanna J. Church, Catherine Clinton, Wenjun Kang, Margaret E. Macy, Laura E. MacConaill, Seong Choi, Susan I. Vear
Publikováno v:
Cancer Research. 80:A28-A28
Background: Gene variants with potential therapeutic significance have been reported in 30-60% of childhood malignancies. The 12-institution Genomic Assessment Informs Novel therapy (GAIN) consortium is conducting the individualized cancer therapy 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bfaebf7e35f984f63aff22e6b921782
https://doi.org/10.1158/1538-7445.pedca19-a28
https://doi.org/10.1158/1538-7445.pedca19-a28
Autor:
Julia Glade Bender, Brian D. Crompton, Daniel A. Weiser, Neal I. Lindeman, Dierdre Reidy, Steven G. DuBois, Gianna R. Strand, Alanna J. Church, Katherine A. Janeway, Rochelle Bagatell, Luke Maese, Alma Imamovic-Tuco, Amit J. Sabnis, Robert S. Pinches, Duong Doan, Laura Corson, Navin R. Pinto, Catherine Clinton, Eliezer M. Van Allen, Theodore W. Laetsch, Marian H. Harris, Lobin A. Lee, Mark A. Applebaum, Susan I. Vear, Margaret E. Macy
Publikováno v:
Cancer Research. 80:A59-A59
Introduction: Molecular techniques have been incorporated into the diagnostic algorithms for many specific tumors, but the diagnostic role of next-generation sequencing has not been described at a population level. We report diagnostically relevant a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::637b53379bacbe50866bf619c875f8fa
https://doi.org/10.1158/1538-7445.pedca19-a59
https://doi.org/10.1158/1538-7445.pedca19-a59
Autor:
Brian D. Crompton, Daniel A. Weiser, Julia Glade-Bender, Alma Imamovic, Amit J. Sabnis, Catherine Clinton, AeRang Kim, Susan I. Vear, R. Seth Pinches, Katherine A. Janeway, Luke Maese, Alanna J. Church, Rochelle Bagatell, Laura Corson, Margaret E. Macy, Deirdre Reidy, Lobin A. Lee, Mark A. Applebaum, Theodore W. Laetsch, Gianna R. Strand, Navin R. Pinto, Eliezer M. Van Allen, Steven G. DuBois, Neal I. Lindeman
Publikováno v:
Cancer Research. 80:B13-B13
Introduction: Gene fusions are important oncogenic drivers with significant clinical impact in some cancer types. This is particularly true in pediatric cancers that often have low mutational burden and lack other diagnostic markers and therapeutic t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fe7e9d6a278288aaa185501db9c9411
https://doi.org/10.1158/1538-7445.pedca19-b13
https://doi.org/10.1158/1538-7445.pedca19-b13
Autor:
Jeremy A. Ross, Michelle Schmidt, Ashish Bajel, Bo Tong, Seong Lin Khaw, Jessica Leonard, Robin E. Norris, Susan I. Vear, Wendy Stock, Ahmed Salem, Lindsey Bensman, Jeffrey E. Rubnitz, Elias Jabbour, Thomas B. Alexander, Vinod Pullarkat, Charles G. Mullighan, Amanda Jacobson, Norman J. Lacayo, Ying Zhou
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 19:S184-S185
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fa722477089df3f463fe004c6eed407
https://doi.org/10.1016/j.clml.2019.07.022
https://doi.org/10.1016/j.clml.2019.07.022
Autor:
Jessica Leonard, Ahmed Salem, Robin E. Norris, Amanda Jacobson, Jeremy A. Ross, Susan I. Vear, Lindsey Bensman, Bo Tong, Thomas B. Alexander, Elias Jabbour, Norman J. Lacayo, Vinod Pullarkat, Ashish Bajel, Michelle Schmidt, Seong Lin Khaw, Joseph T. Opferman, Wendy Stock, Jeffrey E. Rubnitz, Charles G. Mullighan, Lang Zhou
Publikováno v:
Blood. 134:285-285
Background: There remains an unmet need for novel therapeutic strategies for relapsed or refractory (R/R) acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LLy). Venetoclax (Ven) is a highly selective BCL-2 inhibitor with established eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ef7620527821c17c805186dc639bb19
https://doi.org/10.1182/blood-2019-126977
https://doi.org/10.1182/blood-2019-126977