Macrophage-derived netrin-1 promotes abdominal aortic aneurysm formation by activating MMP3 in vascular smooth muscle cells

Autor: Tarik Hadi, Ludovic Boytard, Michele Silvestro, Dornazsadat Alebrahim, Samson Jacob, Jordyn Feinstein, Krista Barone, Wes Spiro, Susan Hutchison, Russell Simon, Debra Rateri, Florence Pinet, David Fenyo, Mark Adelman, Kathryn J. Moore, Holger K. Eltzschig, Alan Daugherty, Bhama Ramkhelawon

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)

Abdominal aortic aneurysms (AAA) are characterized by extensive extracellular matrix degradation. Here Hadi et al. identify a netrin-1/neogenin-based crosstalk between macrophages and vascular smooth muscle cells (VSMCs), leading to the secretion of

Externí odkaz: https://doaj.org/article/6a80aa6aa5a6430686da689e4970e306

Author response: FSH-blocking therapeutic for osteoporosis

Autor: Funda Korkmaz, Anisa Azatovna Gumerova, Tan-Chun Kuo, Sakshi Gera, Damini Sant, Victoria DeMambro, Karthyayani Sudha, Ashley Padilla, Geoffrey Prevot, Jazz Munitz, Abraham Teunissen, Mandy MT van Leent, Tomas GJM Post, Jessica C Fernandes, Jessica Netto, Farhath Sultana, Eleanor Shelly, Satish Rojekar, Pushkar Kumar, Liam Cullen, Jiya Chatterjee, Anusha Pallapati, Sari Miyashita, Hasni Kannangara, Megha Bhongade, Puja Sengupta, Kseniia Ievleva, Valeriia Muradova, Rogerio Batista, Cemre Robinson, Anne Macdonald, Susan Hutchison, Mansi Saxena, Marcia Meseck, John Caminis, Jameel Iqbal, Maria I New, Vitaly Ryu, Se-Min Kim, Jay J Cao, Neeha Zaidi, Zahi A Fayad, Daria Lizneva, Clifford J Rosen, Tony Yuen, Mone Zaidi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f2dfd9cec54c485a66cbeff26c8bed89
https://doi.org/10.7554/elife.78022.sa2

RF10 | PMON205 LH/CG Receptor Activation Protects Mice from Diet-Induced Obesity and Modifies Adipose Tissue Immune Response

Autor: Daria Lizneva, Kseniia Ievleva, Anisa Gumerova, Eleanor Shelly, Funda Korkmaz, Valeriia Muradova, Jessica Netto, Tanchun Kuo, Farhath Sultana, Pushkar Kumar, Natan Kramskiy, Vitaly Ryu, Ashley Padilla, Susan Hutchison, Tony Yuen, Mone Zaidi

Publikováno v: Journal of the Endocrine Society. 6:A27-A28

Menopause is associated with the loss of LH ovulatory surges and enhanced visceral adiposity. Visceral fat depots increase from 5-8% at premenopause to 15-20% of total body fat at postmenopause. Here, we report that high-dose LH, hCG, or small molecu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aa38041fa8fb0c350494a5e852de94ce
https://doi.org/10.1210/jendso/bvac150.058

Macrophage-derived netrin-1 promotes abdominal aortic aneurysm formation by activating MMP3 in vascular smooth muscle cells

Autor: Holger K. Eltzschig, Samson T. Jacob, Debra L. Rateri, Mark A. Adelman, Tarik Hadi, Kathryn J. Moore, Dornazsadat Alebrahim, Alan Daugherty, Michele Silvestro, Wes Spiro, Florence Pinet, Bhama Ramkhelawon, Jordyn Feinstein, Susan Hutchison, Ludovic Boytard, Russell Simon, David Fenyö, Krista Barone

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2018, 9 (1), ⟨10.1038/s41467-018-07495-1⟩
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications, 2018, 9 (1), ⟨10.1038/s41467-018-07495-1⟩

Abdominal aortic aneurysms (AAA) are characterized by extensive extracellular matrix (ECM) fragmentation and inflammation. However, the mechanisms by which these events are coupled thereby fueling focal vascular damage are undefined. Here we report t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf9e07e49272643fb5359eeb171426b5
https://hal.archives-ouvertes.fr/hal-02267415

Modulation of ambient temperature promotes inflammation and initiates atherosclerosis in wild type C57BL/6 mice

Autor: Daniel A. Giles, Christopher L. Karp, Monica Cappelletti, Susan Hutchison, Rebekah Karns, Kathryn J. Moore, Traci E. Stankiewicz, Senad Divanovic, Bhama Ramkhelawon, Rajib Mukherjee, Elizabeth M. Donelan

Publikováno v: Molecular Metabolism
Molecular Metabolism, Vol 5, Iss 11, Pp 1121-1130 (2016)

Objectives Obesity and obesity-associated inflammation is central to a variety of end-organ sequelae including atherosclerosis, a leading cause of death worldwide. Although mouse models have provided important insights into the immunopathogenesis of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f848f3c0d88e37dfe69e0c65d4130ec1
https://pubmed.ncbi.nlm.nih.gov/27818938