Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Susan Hoare"'
Autor:
Susan Hoare, John Radford, Elizabeth Trehu, Sandra J. Strauss, Simon P. Joel, Lynda Millard, Peter Johnson, Frances R. Balkwill, Sarah Vinnecombe, T. Andrew Lister, Ama Z. S. Rohatiner, David P. Schenkein, Anthony Boral, Lenushka Maharaj
Publikováno v:
Journal of Clinical Oncology. 24:2105-2112
Purpose To determine the efficacy of bortezomib in patients with lymphoid malignancy, correlating clinical response with effect on plasma cytokines and in vitro activity in primary cultures. Patients and Methods Patients received bortezomib (1.3 mg/m
Autor:
S. Wilner, Frances R. Balkwill, Sethupathi R. Muthuramalingam, Srinivasan Madhusudan, K Kaur, D Talbot, Cheng Han, Trivadi S. Ganesan, J P Braybrooke, Susan Hoare, Martin Foster, Adrian L. Harris
Publikováno v:
Clinical Cancer Research. 10:6528-6534
Purpose: Tumor necrosis factor (TNF) α is a key player in the tumor microenvironment and is involved in the pathogenesis of breast cancer. Etanercept is a recombinant human soluble p75 TNF receptor that binds to TNF-α and renders it biologically un
Publikováno v:
Journal of Biological Chemistry. 276:6695-6702
An alpha-helical motif containing the sequence LXXLL is required for the ligand-dependent binding of transcriptional co-activators to nuclear receptors. By using a peptide inhibition assay, we have defined the minimal "core" LXXLL motif as an 8-amino
Publikováno v:
Nature. 387:733-736
The binding of lipophilic hormones, retinoids and vitamins to members of the nuclear-receptor superfamily modifies the DNA-binding and transcriptional properties of these receptors, resulting in the activation or repression of target genes1,2. Ligand
Autor:
F L'Horset, Sophie Dauvois, Malcolm G. Parker, Gabriela N. Lopez, Susan Hoare, Peter J. Kushner, Vincent Cavaillès
Publikováno v:
The EMBO Journal. 14:3741-3751
A conserved region in the hormone-dependent activation domain AF2 of nuclear receptors plays an important role in transcriptional activation. We have characterized a novel nuclear protein, RIP140, that specifically interacts in vitro with this domain
Autor:
Eleni Timotheadou, Susan Hoare, Frances R. Balkwill, NF Li, C. Lee, Robert Corringham, Michelle Harrison, Eva Obermueller, Martin Gore, Tim Eisen, D. Mike King, Kellie A. Charles, Kim Edmonds, Nick Maisey, Roger A'Hern, Mark DeWitte, Kate Hall, David Chao
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 25(29)
PurposeTumor necrosis factor α (TNF-α) may play a role in renal cell carcinoma (RCC). We performed two sequential phase II studies of infliximab, an anti–TNF-α monoclonal antibody, in patients with immunotherapy-resistant or refractory RCC.Patie
Autor:
S. Wilner, J P Braybrooke, Sethupathi R. Muthuramalingam, K Kaur, Frances R. Balkwill, Srinivasan Madhusudan, Cheng Han, Susan Hoare, Trivadi S. Ganesan
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 23(25)
PurposeConvincing data support the link between inflammation and ovarian cancer. Tumor necrosis factor-alpha (TNF-α), a major mediator of inflammation, is chronically produced in the ovarian tumor microenvironment and may enhance tumor growth and in
Autor:
Birge Berns, Thomas A. Puchalski, Susan Hoare, Peter C.C. Fong, Shahneen Sandhu, Brenda Tromp, Amita Patnaik, J. De-Bono, Christina Messiou, Frances R. Balkwill, David Olmos, Kyri Papadopoulos, Anthony W. Tolcher
Publikováno v:
Molecular Cancer Therapeutics. 8:A102-A102
Background: The chemokine CCL2 / MCP-1 is highly expressed in multiple tumor types. Overexpression of CCL2 is associated with more advanced disease and a worse prognosis in some cancers. CCL2 plays a pivotal role in recruitment of tumor-associated ma
Autor:
Mark Sydenham, Susan Hoare, Malcolm G. Parker, Roger White, Stephen E. Fawell, Martin John Page
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 87(17)
Many estrogen-antagonist and -agonist ligands have been synthesized, some of which have proved clinically important in the treatment of hormone-dependent breast tumors and endocrine disorders. Here we show that the "pure" antiestrogen ICI 164,384 inh