Zobrazeno 1 - 10
of 321
pro vyhledávání: '"Susan Heavey"'
Autor:
Dengxiong Li, Fanglin Shao, Qingxin Yu, Ruicheng Wu, Zhouting Tuo, Jie Wang, Luxia Ye, Yiqing Guo, Koo Han Yoo, Mang Ke, Uzoamaka Adaobi Okoli, Chaipanichkul Premkamon, Yubo Yang, Wuran Wei, Susan Heavey, William C. Cho, Dechao Feng
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Drug resistance remains a significant challenge in cancer treatment. Recently, the interactions among various cell types within the tumor microenvironment (TME) have deepened our understanding of the mechanisms behind treatment resistance. T
Externí odkaz:
https://doaj.org/article/aa291e3c3fb841a8b7443a8612baab78
Autor:
Zhouting Tuo, Ying Zhang, Dengxiong Li, Yetong Wang, Ruicheng Wu, Jie Wang, Qingxin Yu, Luxia Ye, Fanglin Shao, Dilinaer Wusiman, Yubo Yang, Koo Han Yoo, Mang Ke, Uzoamaka Adaobi Okoli, William C. Cho, Susan Heavey, Wuran Wei, Dechao Feng
Publikováno v:
Pharmacological Research, Vol 206, Iss , Pp 107302- (2024)
Bladder cancer stands as a prevalent global malignancy, exhibiting notable sex-based variations in both incidence and prognosis. Despite substantial strides in therapeutic approaches, the formidable challenge of drug resistance persists. The genomic
Externí odkaz:
https://doaj.org/article/1d31c56b193f4881b92ac0f79e91bb2f
Autor:
Dengxiong Li, Qingxin Yu, Ruicheng Wu, Zhouting Tuo, Jie Wang, Luxia Ye, Fanglin Shao, Premkamon Chaipanichkul, Koo Han Yoo, Wuran Wei, Uzoamaka Adaobi Okoli, Shi Deng, Mang Ke, William C. Cho, Susan Heavey, Dechao Feng
Publikováno v:
Redox Biology, Vol 73, Iss , Pp 103208- (2024)
Background: Recently, numerous studies have reported the interaction between senescence and oxidative stress in cancer. However, there is a lack of a comprehensive understanding of the precise mechanisms involved. Aim: Therefore, our review aims to s
Externí odkaz:
https://doaj.org/article/1abbc309d0dd4304831f44f28540381a
Autor:
Deniz Bakkalci, Georgina Al-Badri, Wei Yang, Andy Nam, Yan Liang, Syed Ali Khurram, Susan Heavey, Stefano Fedele, Umber Cheema
Publikováno v:
Materials Today Bio, Vol 24, Iss , Pp 100923- (2024)
Stromal cells are key components of the tumour microenvironment (TME) and their incorporation into 3D engineered tumour-stroma models is essential for tumour mimicry. By engineering tumouroids with distinct tumour and stromal compartments, it has bee
Externí odkaz:
https://doaj.org/article/977c36513ebd473c84c94da9666fe446
Autor:
Jingyi Huang, Da Huang, Xiaohao Ruan, Jinlun Huang, Danfeng Xu, Susan Heavey, Jonathan Olivier, Rong Na
Publikováno v:
Cancer Medicine, Vol 12, Iss 3, Pp 3468-3476 (2023)
Abstract Background Legislation of cannabis use has been approved in many European and North American countries. Its impact on urological cancers is unclear. This study was conducted to explore the association between cannabis use and the risk of uro
Externí odkaz:
https://doaj.org/article/c2cbffe47a4945119645905a03bf60a1
Autor:
Sabina Luszczak, Benjamin S. Simpson, Urszula Stopka-Farooqui, Vignesh Krishna Sathyadevan, Lina M. Carmona Echeverria, Christopher Kumar, Helena Costa, Aiman Haider, Alex Freeman, Charles Jameson, Marzena Ratynska, Imen Ben-Salha, Ashwin Sridhar, Greg Shaw, John D. Kelly, Hayley Pye, Kathy A. Gately, Hayley C. Whitaker, Susan Heavey
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Abstract PIM and PI3K/mTOR pathways are often dysregulated in prostate cancer, and may lead to decreased survival, increased metastasis and invasion. The pathways are heavily interconnected and act on a variety of common effectors that can lead to th
Externí odkaz:
https://doaj.org/article/5720892a10484524bbddcc6413152966
Autor:
Saurabh Singh, Harriet Rogers, Baris Kanber, Joey Clemente, Hayley Pye, Edward W. Johnston, Tom Parry, Alistair Grey, Eoin Dinneen, Greg Shaw, Susan Heavey, Urszula Stopka-Farooqui, Aiman Haider, Alex Freeman, Francesco Giganti, David Atkinson, Caroline M. Moore, Hayley C. Whitaker, Daniel C. Alexander, Eleftheria Panagiotaki, Shonit Punwani
Publikováno v:
Radiology. 305:623-630
Background In men suspected of having prostate cancer (PCa), up to 50% of men with positive multiparametric MRI (mpMRI) findings (Prostate Imaging Reporting and Data System [PI-RADS] or Likert score of 3 or higher) have no clinically significant (Gle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af9f6cf177948a23cda37b6a20860c17
https://doi.org/10.1148/radiol.212536
https://doi.org/10.1148/radiol.212536
Autor:
Roisin Sullivan, Susan Heavey, David G Graham, Rachel Wellman, Saif Khan, Sri Thrumurthy, Benjamin S Simpson, Tina Baker, Sarah Jevons, Jose Ariza, Victor Eneh, Hayley Pye, Hayley Luxton, Rifat Hamoudi, Hayley Whitaker, Laurence B Lovat
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0229791 (2020)
Saliva represents an ideal matrix for diagnostic biomarker development as it is readily available and requires no invasive collection procedures. However, salivary RNA is labile and rapidly degrades. Previous attempts to isolate RNA from saliva have
Externí odkaz:
https://doaj.org/article/bfb08694d38e4c588b963dcf60b1bbe1
Autor:
Susan Heavey, Paul Dowling, Gillian Moore, Martin P. Barr, Niamh Kelly, Stephen G. Maher, Sinead Cuffe, Stephen P. Finn, Kenneth J. O’Byrne, Kathy Gately
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Abstract The PI3K-mTOR pathway is involved in regulating all hallmarks of cancer, and is often dysregulated in NSCLC, making it an attractive therapeutic target in this setting. Acquired resistance to PI3K-mTOR inhibition is a major hurdle to overcom
Externí odkaz:
https://doaj.org/article/a8ae152a78804d6da7975d71e4a44b98
Publikováno v:
Biomolecules, Vol 11, Iss 12, p 1794 (2021)
Background and aims: Despite recent advances in advanced prostate cancer treatments, clinical biomarkers or treatments for men with such cancers are imperfect. Targeted therapies have shown promise, but there remain fewer actionable targets in prosta
Externí odkaz:
https://doaj.org/article/f63f4b869e154b51a815c0bca43220c3