Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Susan Haller"'
Autor:
Hans D. Brightbill, Eric Suto, Nicole Blaquiere, Nandhini Ramamoorthi, Swathi Sujatha-Bhaskar, Emily B. Gogol, Georgette M. Castanedo, Benjamin T. Jackson, Youngsu C. Kwon, Susan Haller, Justin Lesch, Karin Bents, Christine Everett, Pawan Bir Kohli, Sandra Linge, Laura Christian, Kathy Barrett, Allan Jaochico, Leonid M. Berezhkovskiy, Peter W. Fan, Zora Modrusan, Kelli Veliz, Michael J. Townsend, Jason DeVoss, Adam R. Johnson, Robert Godemann, Wyne P. Lee, Cary D. Austin, Brent S. McKenzie, Jason A. Hackney, James J. Crawford, Steven T. Staben, Moulay H. Alaoui Ismaili, Lawren C. Wu, Nico Ghilardi
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Clinical trials of BAFF blockade with belimumab have shown partial efficacy for the treatment of systemic lupus erythematosus (SLE), so other therapeutic options are required. Here, the authors present a new small molecule inhibitor that targets NIK
Externí odkaz:
https://doaj.org/article/c1b21708fc0a4c58b4c58242d9d32c50
Publikováno v:
Journal of Histotechnology. 45:182-194
Traumatic, inherited, and age-related degenerative diseases of the retina, such as retinal detachment, retinitis pigmentosa, and age-related macular degeneration, are characterized by the irreversible loss of retinal neurons. While current treatments
Autor:
Luz D. Orozco, Leah Owen, Jeffrey Hofmann, Amy D. Stockwell, Jianhua Tao, Susan Haller, Vineeth T. Mukundan, Christine Clarke, Jessica Lund, Akshayalakshmi Sridhar, Julie L. Barr, Rylee A. Zavala, Elijah C. Graves, Charles Zhang, Nadine Husami, Robert Finley, Elizabeth Au, John H. Lillvis, Michael H. Farkas, Akbar Shakoor, Richard M. Sherva, Ivana K. Kim, Joshua S. Kaminker, Michael J. Townsend, Lindsay A. Farrer, Brian L. Yaspan, Hsu-Hsin Chen, Margaret M. DeAngelis
Age-related Macular Degeneration (AMD) is a leading cause of blindness, affecting 200 million people worldwide. We present a comprehensive molecular atlas for different stages of AMD.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a07fcd58dd2422fa1d90174ae6aa8727
Autor:
Luz D. Orozco, Leah A. Owen, Jeffrey Hofmann, Amy D. Stockwell, Jianhua Tao, Susan Haller, Vineeth T. Mukundan, Christine Clarke, Jessica Lund, Akshayalakshmi Sridhar, Oleg Mayba, Julie L. Barr, Rylee A. Zavala, Elijah C. Graves, Charles Zhang, Nadine Husami, Robert Finley, Elizabeth Au, John H. Lillvis, Michael H. Farkas, Akbar Shakoor, Richard Sherva, Ivana K. Kim, Joshua S. Kaminker, Michael J. Townsend, Lindsay A. Farrer, Brian L. Yaspan, Hsu-Hsin Chen, Margaret M. DeAngelis
Publikováno v:
Cell Genomics. :100302
Autor:
Susan Haller, Hai Ngu, Wendy Lam, Sara Chan, Rohit Reja, Jeffrey Eastham-Anderson, Jeffrey Hung, Brad Bolon, Felix Chu, Sarah K. Kummerfeld, Debra L. Dugger, Ronald E. Ferrando, Debra Dunlap, Vishva M. Dixit, Arundhati Sengupta-Ghosh, Ying-Jiun Chen, Kim Newton, Joseph W. Lewcock, Susan Sa, Joshua D. Webster, Jinfeng Liu, Janet Tao, Dorothy French, Zora Modrusan
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The ubiquitin ligase CRL4COP1/DET1 modifies specific transcription factor substrates with polyubiquitin so that they are degraded. However, the Ras–MEK–ERK signaling pathway can inactivate CRL4COP1/DET1 and thereby promote the rapid
Autor:
Eric Suto, Lawren C. Wu, Karin Bents, Justin Lesch, Benjamin T. Jackson, Peter W. Fan, Wyne P. Lee, Laura Christian, Nicole Blaquiere, Nandhini Ramamoorthi, Adam R. Johnson, Emily B. Gogol, Steven T. Staben, Susan Haller, Pawan Bir Kohli, Zora Modrusan, Sandra Linge, Jason DeVoss, James J. Crawford, Christine Everett, Kelli Veliz, Leonid M. Berezhkovskiy, Jason A. Hackney, Georgette Castanedo, Allan Jaochico, Cary D. Austin, Nico Ghilardi, Youngsu Kwon, Swathi Sujatha-Bhaskar, Robert Godemann, Hans Brightbill, Michael J. Townsend, Moulay Hicham Alaoui Ismaili, Brent S. McKenzie, Kathy Barrett
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communications
Nature Communications
NF-κB-inducing kinase (NIK) mediates non-canonical NF-κB signaling downstream of multiple TNF family members, including BAFF, TWEAK, CD40, and OX40, which are implicated in the pathogenesis of systemic lupus erythematosus (SLE). Here, we show that
Autor:
Eric Suto, Jefferey Eastham‐Anderson, Lydia Santell, Peng Luan, Yanmei Lu, Yvonne Franke, Susan Haller, Maria Mouchess, Jason A. Hackney, Craig Blanchette, Christine Tam, Robert A. Lazarus, Sara Chan, Martine Darwish, Cary D. Austin, Dongping He, Wyne P. Lee, Bingbing Dai, Tangsheng Yi, Yi Cao
Publikováno v:
The FASEB Journal. 33
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1857
Activation of the kinase RIPK3 (receptor interacting protein kinase 3) is a hallmark of cells dying by necroptosis. RIPK3 phosphorylates both itself and the pseudokinase MLKL (mixed lineage kinase-like) resulting in MLKL translocation to membranes an
Publikováno v:
Programmed Necrosis ISBN: 9781493987535
Activation of the kinase RIPK3 (receptor interacting protein kinase 3) is a hallmark of cells dying by necroptosis. RIPK3 phosphorylates both itself and the pseudokinase MLKL (mixed lineage kinase-like) resulting in MLKL translocation to membranes an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fddeb1aedc99f81147cbe31bd02a3a1
https://doi.org/10.1007/978-1-4939-8754-2_15
https://doi.org/10.1007/978-1-4939-8754-2_15
Autor:
Maria Mouchess, Eric Suto, Sara Chan, Bingbing Dai, Christine Tam, Yi Cao, Martine Darwish, Dongping He, Susan Haller, Jeffrey Eastham-Anderson, Yvonne Franke, Craig Blanchette, Wyne Lee, Cary Austin, Robert Lazarus, Tangsheng Yi
Publikováno v:
The Journal of Immunology. 202:132.4-132.4
Loss of B cell tolerance and generation of autoreactive anti-nuclear antibodies are hallmarks of systemic lupus erythematosus and lupus nephritis. The mechanism of anti-nuclear immunoglobulin accumulation and clearance in lupus nephritis pathogenesis