Výsledky vyhledávání - "Susan Goorden"

Akademický článek

Sex differences in the association of sphingolipids with age in Dutch and South-Asian Surinamese living in Amsterdam, the Netherlands

Autor: Mirthe Muilwijk, Nardie Callender, Susan Goorden, Frédéric M. Vaz, Irene G. M. van Valkengoed

Publikováno v: Biology of Sex Differences, Vol 12, Iss 1, Pp 1-14 (2021)

Abstract Background Men have a higher risk for cardiovascular disease (CVD) early in life, while women have a higher risk later in life. The sex-related differences in CVD risk, especially by age, could be related to sphingolipid metabolism. We compa

Externí odkaz: https://doaj.org/article/3e4d6fe34822422d8d74ea3cd8b161e7

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

The Shiga Toxin Receptor Globotriaosylceramide as Therapeutic Target in Shiga Toxin E. coli Mediated HUS

Autor: Wouter J. C. Feitz, Romy Bouwmeester, Thea J. A. M. van der Velden, Susan Goorden, Christoph Licht, Lambert P. J. W. van den Heuvel, Nicole C. A. J. van de Kar

Publikováno v: Microorganisms, Vol 9, Iss 10, p 2157 (2021)

In 90% of the cases, childhood hemolytic uremic syndrome (HUS) is caused by an infection with the Shiga toxin (Stx) producing E. coli bacteria (STEC-HUS). Stx preferentially binds to its receptor, the glycosphingolipid, globotriaosylceramide (Gb3), p

Externí odkaz: https://doaj.org/article/494af96ddb7a437ba2b31e387ac46ae3

Zobrazit plný text záznamu

Akademický článek

Reference values for interleukin-6 and interleukin-8 in cord blood of healthy term neonates and their association with stress-related perinatal factors.

Autor: Daan Barug, Susan Goorden, Martien Herruer, Moira Müller, Richard Brohet, Peter de Winter

Publikováno v: PLoS ONE, Vol 9, Iss 12, p e114109 (2014)

BACKGROUND: Automated interleukin assays are promising diagnostic aids for early-onset neonatal sepsis, however, reference values for healthy term neonates are incompletely known. The goal of this study is to determine reference values for interleuki

Externí odkaz: https://doaj.org/article/691d01f64965421682ceeade2ba3e0ff

Zobrazit plný text záznamu

PAK2 is an effector of TSC1/2 signaling independent of mTOR and a potential therapeutic target for Tuberous Sclerosis Complex

Autor: Karla C. S. Queiroz, Susan Goorden, Marco J. Bruno, Maria M. Alves, C. Arnold Spek, Jasper J. Anink, Mark Nellist, Eleonora Aronica, Maikel P. Peppelenbosch, Jetse Scholma, Gwenny M. Fuhler, Ype Elgersma, Marianne Hoogeveen-Westerveld

Publikováno v: Scientific reports, 5. Nature Publishing Group
Scientific Reports, 5:14534. Nature Publishing Group
Scientific Reports, 5. Nature Publishing Group
Scientific Reports

Tuberous sclerosis complex (TSC) is caused by inactivating mutations in either TSC1 or TSC2 and is characterized by uncontrolled mTORC1 activation. Drugs that reduce mTOR activity are only partially successful in the treatment of TSC, suggesting that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c418525df63a1314d8d4a2b37c7c1d6
https://pure.amc.nl/en/publications/pak2-is-an-effector-of-tsc12-signaling-independent-of-mtor-and-a-potential-therapeutic-target-for-tuberous-sclerosis-complex(1b097c6c-42e5-4546-8670-4a2d7632363e).html

Zobrazit plný text záznamu

Rheb regulates mitophagy induced by mitochondrial energetic status

Autor: Muriel Priault, Rodrigue Rossignol, Caroline Jose, Julie Lavie, Susan Goorden, Giovanni Benard, Hamid Reza Rezvani, Emilie Obre, Ype Elgersma, Su Melser, Etienne Hébert Chatelain, Walid Mahfouf

Publikováno v: Cell Metabolism, 17(5), 719-730. Cell Press
Cell Metab
Cell Metab, 2013, 17 (5), pp.719-30. ⟨10.1016/j.cmet.2013.03.014⟩

International audience; Mitophagy has been recently described as a mechanism of elimination of damaged organelles. Although the regulation of the amount of mitochondria is a core issue concerning cellular energy homeostasis, the relationship between

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8753ea8a88a7197e6b7428db1abb9bf
https://pure.eur.nl/en/publications/31751cb7-5b61-4ce2-b60c-3dc6f529270a

Zobrazit plný text záznamu

Mammalian Target of Rapamycin Complex I (mTORC1) Activity in Ras Homologue Enriched in Brain (Rheb)-Deficient Mouse Embryonic Fibroblasts

Autor: Susan Goorden, Marlous J. Groenewoud, Richard F. Lamb, Fried J. T. Zwartkruis, Ype Elgersma, Jorien Kassies, Wendy Pellis-van Berkel

Publikováno v: PLoS One (print), 8(11). Public Library of Science
PLoS ONE
PLoS ONE, Vol 8, Iss 11, p e81649 (2013)

The Ras-like GTPase Rheb has been identified as a crucial activator of mTORC1. Activation most likely requires a direct interaction between Rheb and mTOR, but the exact mechanism remains unclear. Using a panel of Rheb-deficient mouse embryonic fibrob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bfd4f4aa560537314d1d10a8310b7cd
https://hdl.handle.net/1765/67088

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání