Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Susan Gentleman"'
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Here we describe a new family of carotenoid cleavage oxygenases (CCOs) in metazoans, the BCO2-like (BCOL) clade, which contains lancelet, nematode, and molluscan carotenoid oxygenase sequences. Phylogenetic analysis of CCOs in all kingdoms o
Externí odkaz:
https://doaj.org/article/f411c555a86b4c2490a23365c5dbfb0d
Autor:
Sheetal Uppal, Sergey A. Dergunov, Weiyu Zhang, Susan Gentleman, T. Michael Redmond, Eugene Pinkhassik, Eugenia Poliakov
Publikováno v:
Antioxidants, Vol 10, Iss 3, p 413 (2021)
An extensive body of work has documented the antioxidant role of xanthophylls (lutein and zeaxanthin) in human health and specifically how they provide photoprotection in human vision. More recently, evidence is emerging for the transcriptional regul
Externí odkaz:
https://doaj.org/article/9bc3785639a741c99060de8039c250ce
Autor:
Eugenia Poliakov, Alexander N Gubin, Olivia Stearn, Yan Li, Maria Mercedes Campos, Susan Gentleman, Igor B Rogozin, T Michael Redmond
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49975 (2012)
In order to maintain visual sensitivity at all light levels, the vertebrate eye possesses a mechanism to regenerate the visual pigment chromophore 11-cis retinal in the dark enzymatically, unlike in all other taxa, which rely on photoisomerization. T
Externí odkaz:
https://doaj.org/article/53942369cd914e799e5ba179fbe3d8c6
Autor:
Sheetal Uppal, Tingting Liu, Emily Galvan, Fatima Gomez, Tishina Tittley, Eugenia Poliakov, Susan Gentleman, T Michael Redmond
Publikováno v:
Life Science Alliance. 6:e202201546
RPE65 retinol isomerase is an indispensable player in the visual cycle between the vertebrate retina and RPE. Although membrane association is critical for RPE65 function, its mechanism is not clear. Residues 107–125 are believed to interact with m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04f7484738b6ef8d9afd631d87cf337d
https://doi.org/10.26508/lsa.202201546
https://doi.org/10.26508/lsa.202201546
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports
Association with the endoplasmic reticulum (ER) membrane is a critical requirement for the catalytic function of RPE65. Several studies have investigated the nature of the RPE65-membrane interaction; however, complete understanding of its mode of mem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f98755fec3eb0fc6563113defc7205d3
http://link.springer.com/article/10.1038/s41598-019-41501-w
http://link.springer.com/article/10.1038/s41598-019-41501-w
Publikováno v:
Adv Exp Med Biol
Retinal Degenerative Diseases ISBN: 9783030273774
Retinal Degenerative Diseases ISBN: 9783030273774
RPE65, the retinal pigment epithelium (RPE) smooth endoplasmic reticulum (sER) membrane-associated retinoid isomerase, plays an indispensable role in sustaining visual function in vertebrates. An important aspect which has attracted considerable atte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b644827f521f1951911741dab6c5e41
https://europepmc.org/articles/PMC9351226/
https://europepmc.org/articles/PMC9351226/
Publikováno v:
Journal of Biological Chemistry. 291:4966-4973
RPE65 is the isomerase catalyzing conversion of all-trans-retinyl ester (atRE) into 11-cis-retinol in the retinal visual cycle. Crystal structures of RPE65 and site-directed mutagenesis reveal aspects of its catalytic mechanism, especially retinyl mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea4f81d525275855cb16c6c3c4694abf
https://doi.org/10.1074/jbc.m115.685651
https://doi.org/10.1074/jbc.m115.685651
Publikováno v:
Biochim Biophys Acta Mol Cell Biol Lipids
The carotenoids are terpenoid fat-soluble pigments produced by plants, algae, and several bacteria and fungi. They are ubiquitous components of animal diets. Carotenoid cleavage oxygenase (CCO) superfamily members are involved in carotenoid metabolis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7778fc60b977608b7608627b746d6f5
https://doi.org/10.1016/j.bbalip.2020.158665
https://doi.org/10.1016/j.bbalip.2020.158665
Publikováno v:
Biophysical Journal. 118:242a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d3cc2a5cb66d22782289eab4a542b60
https://doi.org/10.1016/j.bpj.2019.11.1422
https://doi.org/10.1016/j.bpj.2019.11.1422
Autor:
Michael B. Gorin, Jean Bennett, Unikora Yang, Susan Gentleman, Robert K. Koenekoop, Adda Villanueva, Albert M. Maguire, Xiaowu Gai, T. Michael Redmond, Mark Borchert, Aaron Nagiel, Thomas C. Lee
Publikováno v:
JAMA Ophthalmol
IMPORTANCE: Next-generation sequencing can detect variants of uncertain significance (VUSs), for some of which gene therapy would not be advantageous. Therefore, the pathogenicity of compound heterozygous or homozygous variants should be confirmed be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f51f55bdb15a648a0ff833d7f42d642
https://doi.org/10.1001/jamaophthalmol.2019.3914
https://doi.org/10.1001/jamaophthalmol.2019.3914