Zobrazeno 1 - 10
of 182
pro vyhledávání: '"Susan G Amara"'
Substrate transport and anion permeation proceed through distinct pathways in glutamate transporters
Autor:
Mary Hongying Cheng, Delany Torres-Salazar, Aneysis D Gonzalez-Suarez, Susan G Amara, Ivet Bahar
Publikováno v:
eLife, Vol 6 (2017)
Advances in structure-function analyses and computational biology have enabled a deeper understanding of how excitatory amino acid transporters (EAATs) mediate chloride permeation and substrate transport. However, the mechanism of structural coupling
Externí odkaz:
https://doaj.org/article/84267c63cddb4bf2905edf38e175038c
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109245 (2014)
Excitatory amino acid transporters (EAATs) limit glutamatergic signaling and maintain extracellular glutamate concentrations below neurotoxic levels. Of the five known EAAT isoforms (EAATs 1-5), only the neuronal isoform, EAAT3 (EAAC1), can efficient
Externí odkaz:
https://doaj.org/article/c8d724868ad944adb3fd6fcc7be25424
Autor:
Jennie Garcia-Olivares, Delany Torres-Salazar, William A Owens, Tracy Baust, David P Siderovski, Susan G Amara, Jun Zhu, Lynette C Daws, Gonzalo E Torres
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59788 (2013)
Uptake through the Dopamine Transporter (DAT) is the primary mechanism of terminating dopamine signaling within the brain, thus playing an essential role in neuronal homeostasis. Deregulation of DAT function has been linked to several neurological an
Externí odkaz:
https://doaj.org/article/42b8cc8b80754619b13b8ac662609f99
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35373 (2012)
Regulation of chloride gradients is a major mechanism by which excitability is regulated in neurons. Disruption of these gradients is implicated in various diseases, including cystic fibrosis, neuropathic pain and epilepsy. Relatively few studies hav
Externí odkaz:
https://doaj.org/article/bb656aae16924878922bf5f633ee2895
Autor:
Suzanne M. Underhill, Susan G. Amara
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
The dopamine transporter (DAT) clears neurotransmitters from the extracellular space and serves as an important regulator of signal amplitude and duration at sites of dopamine release. Several different intracellular signaling pathways have been obse
Externí odkaz:
https://doaj.org/article/e8795bcb91684db8b01fa06caf1601ea
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Central Nervous System Pharmacology - Neuropharmacology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be7bfe4f9e3418d554bebdf89014c232
https://doi.org/10.1124/jpet.122.551520
https://doi.org/10.1124/jpet.122.551520
Autor:
Saranya Radhakrishnan, Susan G. Amara
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Central Nervous System Pharmacology - Neuropharmacology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de282affbc56c4c4f9c53486d66e83f0
https://doi.org/10.1124/jpet.122.552010
https://doi.org/10.1124/jpet.122.552010
Publikováno v:
Annual review of pharmacology and toxicology.
Investigations in pharmacology and toxicology range from molecular studies to clinical care. Studies in basic and clinical pharmacology and in preclinical and clinical toxicology are all essential in bringing new knowledge and new drugs into clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec8f2f89a76ed96d0b12cf9d98a1b421
https://pubmed.ncbi.nlm.nih.gov/36270297
https://pubmed.ncbi.nlm.nih.gov/36270297
Publikováno v:
Neurochemical Research
Amphetamines and amphetamine-derivatives elevate neurotransmitter concentrations by competing with endogenous biogenic amines for reuptake. In addition, AMPHs have been shown to activate endocytosis of the dopamine transporter (DAT) which further ele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2f713b75f5cec8fe61f8c6045246c88
https://doi.org/10.1007/s11064-019-02939-6
https://doi.org/10.1007/s11064-019-02939-6
Autor:
Susan G. Amara
Publikováno v:
Science (New York, N.Y.). 375(6582)
This week (17 to 20 February), the virtual annual meeting of the American Association for the Advancement of Science (AAAS, the publisher of Science ) will address the challenges of building the public’s trust and understanding of science by illumi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9624adfda74c337581d8bb9f2d2450b4
https://pubmed.ncbi.nlm.nih.gov/35175824
https://pubmed.ncbi.nlm.nih.gov/35175824