Emerging therapeutic targets for schizophrenia: a framework for novel treatment strategies for psychosis

Autor: Susan F. Sonnenschein, Anthony A. Grace

Publikováno v: Expert Opin Ther Targets

INTRODUCTION: Antipsychotic drugs that target the dopamine system have been central to the treatment of schizophrenia, but their limitations in efficacy, tolerability, and precision necessitate improved treatment strategies. Multiple lines of researc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9361db790679676a430e82da415ad496
https://doi.org/10.1080/14728222.2021.1849144

Dorsolateral Prefrontal Cortex Glutamate/Gamma-Aminobutyric Acid (GABA) Alterations in Clinical High Risk and First-Episode Schizophrenia: A Preliminary 7-T Magnetic Resonance Spectroscopy Imaging Study

Autor: Ahmad Mayeli, Susan F. Sonnenschein, Victor E. Yushmanov, James D. Wilson, Annie Blazer, William Foran, Maria Perica, Finnegan J. Calabro, Beatriz Luna, Hoby P. Hetherington, Deepak K. Sarpal, Fabio Ferrarelli

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 24; Pages: 15846

Converging lines of evidence suggest that an imbalance between excitation and inhibition is present in the dorsolateral prefrontal cortex (DLPFC) of schizophrenia (SCZ). Gamma-aminobutyric-acid (GABA) and, to a lesser extent, glutamate (Glu) abnormal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffab10a1b13a39b253c162bf7d9cac96
https://doi.org/10.3390/ijms232415846

The 2019 Schizophrenia International Research Society Conference, 10-14 April, Orlando, Florida: A summary of topics and trends

Autor: Dennis Hernaus, Susan F. Sonnenschein, Victoria Rodriguez, Jessica A. Wojtalik, Pasquale Di Carlo, Kelsey A. Bonfils, Chantel Kowalchuk, Zhuo-ya Yang, Imke Lemmers-Jansen, Robin Emsley, Musa Sami, Lindsay D. Oliver, Ellen E. Lee, Sunaina Soni, Michael L. Thomas, Abhishekh Ashok, Ali Bani-Fatemi, Ian S. Ramsay, Anna Waterreus, Ana P. Pinheiro, Michael W. Best, Marco Colizzi, Suhas Ganesh, Jerome H. Taylor, Dhruva Ithal, Oladunni Oluwoye, Dominic B. Dwyer, Maria R. Dauvermann, Emily Eisner, Min Tae M. Park, Tina Kristensen, Luis Alameda, Stefan S. du Plessis, Katie M. Lavigne, Helena Passarelli Giroud Joaquim, Sanja Kilian, Susan Berkhout, Brian O'Donoghue, Suzanne N. Avery

Publikováno v: Alameda, L, Ashok, A, Avery, S, Bani-Fatemi, A, Berkhout, S, Best, M, Bonfils, K, Colizzi, M, Dauvermann, M, Plessis, S D, Dwyer, D, Eisner, E, Ganesh, S, Hernaus, D, Ithal, D, Kowalchuk, C, Kristensen, T, Lavigne, K, Lee, E, Lemmers-Jansen, I, O'Donoghue, B, Oliver, L, Oluwoye, O, Park, M T, Di Carlo, P, Joaquim, H P G, Pinheiro, A, Ramsay, I, Rodriguez, V, Sami, M, Soni, S, Sonnenschein, S, Taylor, J, Thomas, M, Waterreus, A, Wojtalik, J, Yang, Z, Emsley, R & Kilian, S 2020, ' The 2019 Schizophrenia International Research Society Conference, 10-14 April, Orlando, Florida : A summary of topics and trends ', Psychiatry Research, vol. 284, pp. 112672 . https://doi.org/10.1016/j.psychres.2019.112672, https://doi.org/10.1016/j.psychres.2019.112672
Alameda, L, Ashok, A, Avery, S, Bani-Fatemi, A, Berkhout, S, Best, M, Bonfils, K, Colizzi, M, Dauvermann, M, Plessis, S D, Dwyer, D, Eisner, E, Ganesh, S, Hernaus, D, Ithal, D, Kowalchuk, C, Kristensen, T, Lavigne, K, Lee, E, Lemmers-Jansen, I, O'Donoghue, B, Oliver, L, Oluwoye, O, Park, M T, Di Carlo, P, Joaquim, H P G, Pinheiro, A, Ramsay, I, Rodriguez, V, Sami, M, Soni, S, Sonnenschein, S, Taylor, J, Thomas, M, Waterreus, A, Wojtalik, J, Yang, Z, Emsley, R & Kilian, S 2020, ' The 2019 Schizophrenia International Research Society Conference, 10–14 April, Orlando, Florida : A summary of topics and trends ', Psychiatry Research, vol. 284, 112672, pp. 1-20 . https://doi.org/10.1016/j.psychres.2019.112672
Eisner, E 2019, ' The 2019 Schizophrenia International Research Society Conference, 10–14 April, Orlando, Florida: A summary of topics and trends. ', Psychiatry Research . https://doi.org/10.1016/j.psychres.2019.112672
Psychiatry Research, 284:112672. Elsevier Ireland Ltd
Psychiatry research
Psychiatry research, vol. 284, pp. 112672

The Schizophrenia International Research Society (SIRS) recently held its first North American congress, which took place in Orlando, Florida from 10-14 April 2019. The overall theme of this year's congress was United in Progress – with the aim of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41dbb264d7d8b22a38f3e3ab99772b13
http://hdl.handle.net/11562/1009864

Insights on current and novel antipsychotic mechanisms from the MAM model of schizophrenia

Autor: Anthony A. Grace, Susan F. Sonnenschein

Publikováno v: Neuropharmacology

Current antipsychotic drugs (APDs) act on D2 receptors, and preclinical studies demonstrate that repeated D2 antagonist administration downregulates spontaneously active DA neurons by producing overexcitation-induced inactivation of firing (depolariz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6825d833ca46618518fc8e790f204a69
https://doi.org/10.1016/j.neuropharm.2019.05.009

M10. Pomaglumetad Methionil Normalizes Increased DA Neuron Activity in the VTA in the Methylazoxymethanol Acetate Developmental Disruption Model of Schizophrenia

Autor: Anthony A. Grace, Susan F. Sonnenschein

Background: Our previous studies show that withdrawal from prior D2 antagonist treatment interferes with the ability of novel target compounds to reverse the hyperresponsive state of the DA system in the methylazoxymethanol acetate (MAM) model of sch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f096e242c08e91cb5a4a880c2079293
https://europepmc.org/articles/PMC5475772/