Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Susan E. Sadler"'
Autor:
Susan E. Sadler, Nicole D. Jacobs
Publikováno v:
Biology of Reproduction. 70:1685-1692
The cholesterol-depleting drug methyl-b-cyclodextrin (Me-bCD) was tested for its effects on amphibian oocyte maturation, cholesterol depletion, and low-density membrane recovery. Progesterone-induced oocyte maturation was accelerated by pretreatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::436b020f0503fdb25e59e54f559544e9
https://doi.org/10.1095/biolreprod.103.026161
https://doi.org/10.1095/biolreprod.103.026161
Analysis of farnesyl transferase activity during hormone-induced maturation ofXenopus laevis oocytes
Autor:
Marc L. Goalstone, Susan E. Sadler
Publikováno v:
The Journal of Experimental Zoology. 286:193-203
Preincubation of Xenopus laevis oocytes with insulin or insulin-like growth factor 1 (IGF-1) resulted in inhibition of farnesyl transferase (FTase) activity measured both in vivo (after microinjection of tritiated farnesyl pyrophosphate and Ras-CVIM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::867f40b82c3379ae386d151fa4038223
https://doi.org/10.1002/(sici)1097-010x(20000201)286:2<193::aid-jez11>3.0.co
https://doi.org/10.1002/(sici)1097-010x(20000201)286:2<193::aid-jez11>3.0.co
Publikováno v:
The Journal of Experimental Zoology. 274:317-325
R59022, a diacylglycerol (DAG) kinase inhibitor, stimulated meiotic maturation of Xenopus laevis oocytes when applied extracellularly. The time course of R59022-induced oocyte maturation was proportional to the concentration of R59022 in the low micr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c8db0f7e62e40c619899a5d6382a993
https://doi.org/10.1002/(sici)1097-010x(19960401)274:5<317::aid-jez7>3.0.co
https://doi.org/10.1002/(sici)1097-010x(19960401)274:5<317::aid-jez7>3.0.co
Publikováno v:
Biology of Reproduction. 54:675-681
Farnesyl transferase (FTase) activity, characterized in extracts of Xenopus laevis oocytes using an in vitro filtration assay, was observed to be at least 80% cytosolic with optimal product formation at pH 7.0. Oocyte FTase displayed enzyme activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e98cc273d717cad69420281655da0b5c
https://doi.org/10.1095/biolreprod54.3.675
https://doi.org/10.1095/biolreprod54.3.675
Autor:
Melanie S. Taghon, Susan E. Sadler
Publikováno v:
Developmental Biology. 163:66-74
Equilibrium analysis of [ 125 I]IGF-1 binding to Xenopus oocytes yielded curvilinear Scatchards supporting the presence of multiple binding sites. High-affinity Binding displayed an apparent K D of 9.0 ± 3.0 n M IGF-1 with maximum total binding of 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08a2c98114594c393ffd321fc8bf12c7
https://doi.org/10.1006/dbio.1994.1123
https://doi.org/10.1006/dbio.1994.1123
Publikováno v:
Biology of reproduction. 82(3)
Insulin-like growth factor 1 (IGF-1)-stimulated amphibian oocyte maturation has been studied extensively by a number of laboratory groups, but in previous studies possible effects of IGF-1 on ovarian follicle cells had not been tested directly. In th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9dfe8b2c034a4102dee58b051f33033
https://pubmed.ncbi.nlm.nih.gov/19923252
https://pubmed.ncbi.nlm.nih.gov/19923252
Autor:
Susan E. Sadler
Publikováno v:
Molecular Endocrinology. 5:1947-1954
Insulin-like growth factor-I (IGF-I) stimulated Xenopus laevis oocyte ribosomal S6 kinase activity 5- to 10-fold, with an apparent EC50 of 0.8 +/- 0.1 nM after 90 min of hormone treatment. IGF-I-stimulated enzyme activity was inhibited by treatment o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a52831699ddd9f06857fc8abd8989f1c
https://doi.org/10.1210/mend-5-12-1947
https://doi.org/10.1210/mend-5-12-1947
Autor:
Susan E. Sadler
Publikováno v:
Molecular Endocrinology. 5:1939-1946
Three phosphodiesterase (PDE) type III inhibitors were tested and found to inhibit Xenopus oocyte maturation induced by insulin with apparent IC50 values of 2.2 +/- 0.2 microM Cl-930, 25 +/- 3 microM imazodan (Cl-914), and 786 +/- 237 microM piroximo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e97613712a4fb9acd1752d9fa5ccbe3b
https://doi.org/10.1210/mend-5-12-1939
https://doi.org/10.1210/mend-5-12-1939
Autor:
Susan E, Sadler, Nicole D, Jacobs
Publikováno v:
Biology of reproduction. 70(6)
The cholesterol-depleting drug methyl-beta-cyclodextrin (Me-beta-CD) was tested for its effects on amphibian oocyte maturation, cholesterol depletion, and low-density membrane recovery. Progesterone-induced oocyte maturation was accelerated by pretre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dd6221618d198599ddc1d850e446fe19
https://pubmed.ncbi.nlm.nih.gov/14766724
https://pubmed.ncbi.nlm.nih.gov/14766724
Autor:
David Davis, Susan E. Sadler
Publikováno v:
Developmental biology. 149(1)
The ability of Xenopus oocytes to undergo insulin- or insulin-like growth factor 1-induced meiotic maturation develops during oogenesis, with cells 1.0 mm in diameter or larger responding in a size-dependent manner. Since insulin-induced oocyte matur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb8735e3f361540b7ca661d3e583fd48
https://pubmed.ncbi.nlm.nih.gov/1728580
https://pubmed.ncbi.nlm.nih.gov/1728580