Výsledky vyhledávání - "Susan E. Puckett"

Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis

Autor: Inna Krieger, James C. Sacchettini, Dirk Schnappinger, Hyungjin Eoh, Sabine Ehrt, Carolina Trujillo, Kyu Y. Rhee, Thomas R. Ioerger, Zhe Wang, Susan E. Puckett

Publikováno v: Proceedings of the National Academy of Sciences. 114

The glyoxylate shunt is a metabolic pathway of bacteria, fungi, and plants used to assimilate even-chain fatty acids (FAs) and has been implicated in persistence of Mycobacterium tuberculosis (Mtb). Recent work, however, showed that the first enzyme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6fa7828588e8ef1a004ee3a8911d1cbf
https://doi.org/10.1073/pnas.1617655114

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Fumarase deficiency causes protein and metabolite succination and intoxicates Mycobacterium tuberculosis

Autor: Kyu Y. Rhee, Pradeepa Jayachandran, Susan E. Puckett, Henrik Molina, Sabine Ehrt, Nadine Ruecker, Carolina Trujillo, Gerardo G. Piroli, Robert S. Jansen, Norma Frizzell

Enzymes of central carbon metabolism are essential mediators of Mycobacterium tuberculosis (Mtb) physiology and pathogenicity, but are often perceived to lack sufficient species selectivity to be pursued as potential drug targets. Fumarase (Fum) is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa048efdc73cc67ac00969e2e1ff32f6
https://europepmc.org/articles/PMC5357164/

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Bacterial Resistance to Antisense Peptide Phosphorodiamidate Morpholino Oligomers

Autor: Susan E. Puckett, Michael Freitag, Kaleb A. Reese, Lucas D. Tilley, Kyle R. Pomraning, Georgi M. Mitev, Valerie M. Mullen, Rudd C. Johnson, Patrick L. Iversen, Brett L. Mellbye, Bruce L. Geller

Publikováno v: Antimicrobial Agents and Chemotherapy

Peptide phosphorodiamidate morpholino oligomers (PPMOs) are synthetic DNA mimics that bind cRNA and inhibit bacterial gene expression. The PPMO (RFF) 3 RXB-AcpP (where R is arginine, F, phenylalanine, X is 6-aminohexanoic acid, B is β-alanine, and A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87de042b8cba156943305f0b0d1820eb

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Inactivation of Fructose-1,6-Bisphosphate Aldolase Prevents Optimal Co-catabolism of Glycolytic and Gluconeogenic Carbon Substrates in Mycobacterium tuberculosis

Autor: Hyungjin Eoh, Kyu Y. Rhee, John S. Spencer, Sabine Ehrt, Dirk Schnappinger, Carolina Trujillo, Mary Jackson, Joeli Marrero, Susan E. Puckett

Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 10, Iss 5, p e1004144 (2014)

Metabolic pathways used by Mycobacterium tuberculosis (Mtb) to establish and maintain infections are important for our understanding of pathogenesis and the development of new chemotherapies. To investigate the role of fructose-1,6-bisphosphate aldol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ec8cd61ac240f79b17cd6aaa8a20e4d
http://europepmc.org/articles/PMC4031216

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Glycolytic and Non-glycolytic Functions of Mycobacterium tuberculosis Fructose-1,6-bisphosphate Aldolase, an Essential Enzyme Produced by Replicating and Non-replicating Bacilli*

Autor: Petra Gest, Gavin J. Ryan, María de la Paz Santangelo, Dirk Schnappinger, Ha Pham, Mercedes Gonzalez-Juarrero, Sabine Ehrt, Susan E. Puckett, John S. Spencer, Racha Daher, Mathieu Coinçon, Marcelo E. Guerin, Jurgen Sygusch, Anne J. Lenaerts, Michel Therisod, Mary Jackson

The search for antituberculosis drugs active against persistent bacilli has led to our interest in metallodependent class II fructose-1,6-bisphosphate aldolase (FBA-tb), a key enzyme of gluconeogenesis absent from mammalian cells. Knock-out experimen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee1199e0fc38e3a49c7765816a52132d
https://europepmc.org/articles/PMC3220552/

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Variations in Amino Acid Composition of Antisense Peptide-Phosphorodiamidate Morpholino Oligomer Affect Potency against Escherichia coli In Vitro and In Vivo ▿

Autor: Brett L. Mellbye, Bruce L. Geller, Susan E. Puckett, Lucas D. Tilley, Patrick L. Iversen

The potency of antisense peptide-phosphorodiamidate morpholino oligomers (PPMOs) was improved by varying the peptide composition. An antisense phosphorodiamidate morpholino oligomer (PMO) complementary to the mRNA of the essential gene acpP (which en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22d484aa8a6301f4b93f52fa76dd0f00
https://europepmc.org/articles/PMC2630659/

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Antisense peptide-phosphorodiamidate morpholino oligomer conjugate: dose-response in mice infected with Escherichia coli

Autor: Brett L. Mellbye, Susan E. Puckett, Bruce L. Geller, Patrick L. Iversen, Lucas D. Tilley

Publikováno v: The Journal of antimicrobial chemotherapy. 59(1)

Objectives Phosphorodiamidate morpholino oligomers (PMOs) are DNA analogues that inhibit translation by an antisense mechanism. Membrane-penetrating peptides attached to PMOs increase PMO efficacy by enhancing penetration through bacterial membranes.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c46c0a18da180d8481e40067ecdc4b59
https://pubmed.ncbi.nlm.nih.gov/17079242

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Akademický článek

Antisense peptide-phosphorodiamidate morpholino oligomer conjugate: dose–response in mice infected with Escherichia coli.

Autor: Lucas D. Tilley, Brett L. Mellbye, Susan E. Puckett, Patrick. L. Iversen, Bruce L. Geller

Publikováno v: Journal of Antimicrobial Chemotherapy (JAC); Jan2007, Vol. 59 Issue 1, p66-73, 8p

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