Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Susan E. Logue"'
Autor:
Gideon Ong, Rosemund Ragetli, Katarzyna Mnich, Bradley W. Doble, Wafa Kammouni, Susan E. Logue
Publikováno v:
Cell Death and Disease, Vol 15, Iss 4, Pp 1-11 (2024)
Abstract The Unfolded Protein Response (UPR) is an essential cellular process activated by the accumulation of unfolded proteins within the Endoplasmic Reticulum (ER), a condition referred to as ER stress. Three ER anchored receptors, IRE1, PERK and
Externí odkaz:
https://doaj.org/article/ce0b60685af34633bbe0b854e73cac1d
Publikováno v:
Biomolecules, Vol 13, Iss 10, p 1503 (2023)
The ubiquitin proteasome system (UPS) utilizes an orchestrated enzymatic cascade of E1, E2, and E3 ligases to add single or multiple ubiquitin-like molecules as post-translational modification (PTM) to proteins. Ubiquitination can alter protein funct
Externí odkaz:
https://doaj.org/article/14a69a1ffa9b4fedabec529787c8d576
Autor:
Gideon Ong, Susan E. Logue
Publikováno v:
Antioxidants, Vol 12, Iss 5, p 981 (2023)
Oxidative stress is caused by an imbalance in cellular redox state due to the accumulation of reactive oxygen species (ROS). While homeostatic levels of ROS are important for cell physiology and signaling, excess ROS can induce a variety of negative
Externí odkaz:
https://doaj.org/article/622b75bf920549c9901b1e707cb35c68
Autor:
Susan E. Logue, Eoghan P. McGrath, Patricia Cleary, Stephanie Greene, Katarzyna Mnich, Aitor Almanza, Eric Chevet, Róisín M. Dwyer, Anup Oommen, Patrick Legembre, Florence Godey, Emma C. Madden, Brian Leuzzi, Joanna Obacz, Qingping Zeng, John B. Patterson, Richard Jäger, Adrienne M. Gorman, Afshin Samali
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
IRE1/XBP-1 activation has a major role in Triple negative breast cancer (TNBC). Here, the authors show that inhibition of IRE1’s RNase activity attenuates autocrine and paracrine signaling of pro-tumorigenic cytokines and synergizes with paclitaxel
Externí odkaz:
https://doaj.org/article/397f4e630bac42c587fdf199a5689e3f
Autor:
Claire M. Robinson, Aaron Talty, Susan E. Logue, Katarzyna Mnich, Adrienne M. Gorman, Afshin Samali
Publikováno v:
Cancers, Vol 13, Iss 2, p 261 (2021)
Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer and one of the leading causes of cancer-associated deaths in the world. It is characterised by dismal response rates to conventional therapies. A major challenge in
Externí odkaz:
https://doaj.org/article/30435bdcaee345e0bc18539b5b22a1d3
Autor:
Melissa Thomas, Izabela Koryga, Adrienne M. Gorman, Leif A. Eriksson, Afshin Samali, Katarzyna Mnich, Karolina Pakos-Zebrucka, Susan E. Logue
Publikováno v:
Journal of Cellular and Molecular Medicine
Stress‐induced apoptosis is mediated primarily through the intrinsic pathway that involves caspase‐9. We previously reported that in caspase‐9‐deficient cells, a protein complex containing ATG5 and Fas‐associated death domain (FADD) facilit
Autor:
Ciaran Richardson, Ivan McConnell, Nahidul Islam, Eibhlin McCole, John Ferguson, John Victor Lamont, Tomás P. Griffin, Chloe Conroy, William P. Martin, Serika D. Naicker, Peter Fitzgerald, Matthew D. Griffin, Susan E. Logue, Sarah Cormican
Publikováno v:
Kidney360
Background We investigated the predictive value of 11 serum biomarkers for renal and mortality end points in people with CKD. Methods Adults with CKD (n=139) were enrolled from outpatient clinics between February 2014 and November 2016. Biomarker qua
Publikováno v:
The Journal of cell biology. 221(6)
Logue, Gorman, and Samali highlight a study by Guttman and colleagues (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202111068) that shows exogenous antigen peptides imported into the ER can activate the ER stress sensor IRE1α, attenuating cross-pr
Publikováno v:
Frontiers in Immunology, Vol 7 (2016)
Cancer immune-surveillance is essential for the inhibition of carcinogenesis. Malignantly transformed cells can be recognised by both the innate and adaptive immune systems through different mechanisms. Immune effector cells induce extrinsic cell dea
Externí odkaz:
https://doaj.org/article/8de69996812447a7ae5a7eb4b00e806a
Autor:
Eoghan P. McGrath, Susan E. Logue, Katarzyna Mnich, Shane Deegan, Richard Jäger, Adrienne M. Gorman, Afshin Samali
Publikováno v:
Cancers, Vol 10, Iss 10, p 344 (2018)
In 2018, in the US alone, it is estimated that 268,670 people will be diagnosed with breast cancer, and that 41,400 will die from it. Since breast cancers often become resistant to therapies, and certain breast cancers lack therapeutic targets, new a
Externí odkaz:
https://doaj.org/article/ab88479294b544bdbaf463692c6eef3a