Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Susan E. Leggett"'
Publikováno v:
Cell Communication and Signaling, Vol 19, Iss 1, Pp 1-24 (2021)
Abstract The epithelial-mesenchymal transition (EMT) is intrinsically linked to alterations of the intracellular cytoskeleton and the extracellular matrix. After EMT, cells acquire an elongated morphology with front/back polarity, which can be attrib
Externí odkaz:
https://doaj.org/article/c870ca742aa94ae3846ffdb718c4bcc4
Autor:
Susan E. Leggett, Thomas M. Valentin, Elisa M Bye, Ian Y. Wong, Dhananjay Bhaskar, Blanche C. Ip, Amanda Khoo, Shoham Benmelech
Publikováno v:
ACS Biomater Sci Eng
Invading cancer cells adapt their migration phenotype in response to mechanical and biochemical cues from the extracellular matrix. For instance, mesenchymal migration is associated with strong cell-matrix adhesions and an elongated morphology, while
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e998d7fffc6a8ab670147ed4a32e1309
https://doi.org/10.1021/acsbiomaterials.9b00519
https://doi.org/10.1021/acsbiomaterials.9b00519
Autor:
Anthony M. Reginato, Adam Driesman, Eui Young So, Olin D Liang, Changqi Sun, Travis Spangler, Mauricio Isaac, Susan E. Leggett, Keith Q. Wu, Patrycja M. Dubielecka‐Szczerba
Publikováno v:
Journal of Cellular Physiology
SH2‐containing inositol‐5′‐phosphatase‐1 (SHIP‐1) controls the phosphatidylinositol‐3′‐kinase (PI3K) initiated signaling pathway by limiting cell membrane recruitment and activation of Akt. Despite the fact that many of the growth f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13983bc895117005ee06edb648f81769
https://doi.org/10.1002/jcp.29063
https://doi.org/10.1002/jcp.29063
Publikováno v:
Cell Communication and Signaling, Vol 19, Iss 1, Pp 1-24 (2021)
Cell Communication and Signaling : CCS
Cell Communication and Signaling : CCS
The epithelial-mesenchymal transition (EMT) is intrinsically linked to alterations of the intracellular cytoskeleton and the extracellular matrix. After EMT, cells acquire an elongated morphology with front/back polarity, which can be attributed to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dfe1d964ead72218392681fd5b820c7
https://doi.org/10.1186/s12964-021-00713-2
https://doi.org/10.1186/s12964-021-00713-2
Autor:
Thomas M. Valentin, Mohak Patel, Ian Y. Wong, Evelyn Kendall Williams, Christian Franck, Amanda Khoo, Susan E. Leggett, Lena Gamboa
Publikováno v:
Proc Natl Acad Sci U S A
Epithelial tissues mechanically deform the surrounding extracellular matrix during embryonic development, wound repair, and tumor invasion. Ex vivo measurements of such multicellular tractions within three-dimensional (3D) biomaterials could elucidat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d0a0795b80cbd25aae4791bfb5db8a6
https://europepmc.org/articles/PMC7084145/
https://europepmc.org/articles/PMC7084145/
Autor:
Jea Yun Sim, Zachary J. Neronha, Dhananjay Bhaskar, Theodora Myrto Perdikari, Susan E. Leggett, Ian Y. Wong
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 116(35)
Migratory cells transition between dispersed individuals and multicellular collectives during development, wound healing, and cancer. These transitions are associated with coordinated behaviors as well as arrested motility at high cell densities, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d539a7fdc3ec099be93839d987fb1074
https://pubmed.ncbi.nlm.nih.gov/31413194
https://pubmed.ncbi.nlm.nih.gov/31413194
Autor:
Evelyn Kendall Williams, Susan E. Leggett, Jea Yun Sim, Ian Y. Wong, Jonathan E. Rubins, Zachary J. Neronha
Publikováno v:
Integrative Biology. 8:1133-1144
Single cells respond heterogeneously to biochemical treatments, which can complicate the analysis of in vitro and in vivo experiments. In particular, stressful perturbations may induce the epithelial-mesenchymal transition (EMT), a transformation thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40a10a8c31d372e35b5a2341f22a1c71
https://doi.org/10.1039/c6ib00139d
https://doi.org/10.1039/c6ib00139d
Publikováno v:
Soft Matter. 12:8327-8337
Collective behaviors emerge from coordinated cell-cell interactions during the morphogenesis of tissues and tumors. For instance, cells may display density-dependent phase transitions from a fluid-like "unjammed" phase to a solid-like "jammed" phase,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25d3fcccf3a1d33e57eb16e9604faf67
https://doi.org/10.1039/c6sm01287f
https://doi.org/10.1039/c6sm01287f
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Spatiotemporal tracking of tracer particles or objects of interest can reveal localized behaviors in biological and physical systems. However, existing tracking algorithms are most effective for relatively low numbers of particles that undergo displa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d227e2f004da074d17b06191973bf5f2
http://europepmc.org/articles/PMC5882970
http://europepmc.org/articles/PMC5882970
Autor:
Ian Y. Wong, Susan E. Leggett
Publikováno v:
Nature Nanotechnology. 12:191-193
A microfluidic chip with progressively stronger magnetic field gradients along its length can sort and classify circulating tumour cells based on the expression of cell surface markers.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ff618afc907a4cd853f40d283053bef
https://doi.org/10.1038/nnano.2016.264
https://doi.org/10.1038/nnano.2016.264